A5042114261- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological diseases and metabolism
- Air Quality and Health Impacts
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Dysphagia Assessment and Management
- Ophthalmology and Eye Disorders
- Nuclear Receptors and Signaling
- EEG and Brain-Computer Interfaces
- Alcoholism and Thiamine Deficiency
- Voice and Speech Disorders
- Genomics and Rare Diseases
- Glycogen Storage Diseases and Myoclonus
- Vehicle emissions and performance
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease and Spinal Disorders
- Hereditary Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Trace Elements in Health
- Nerve injury and regeneration
Michigan State University
2017-2025
John Wiley & Sons (United States)
2024
H-Net: Humanities & Social Sciences Online
2018-2021
Wayne State University
2011-2021
Kiel University
2019
Henry Ford Hospital
2010-2018
Toronto Western Hospital
2012-2016
University of Toronto
2013-2016
University Health Network
2016
Henry Ford Health System
2016
The local injection of botulinum toxin is accepted as the first-line treatment primary cervical dystonia. This approach provides adequate symptomatic relief for most patients, but up to one-third will have an unsatisfactory response. Deep brain stimulation globus pallidus internus has been increasingly used in dystonic syndromes that are refractory best pharmacological approaches. Although dystonia common idiopathic focal dystonia, evidence long-term responsiveness pallidal limited....
The apolipoprotein E (APOE) ε4 allele is the major genetic risk factor for development of late-onset Alzheimer's disease (AD), whereas presence APOE ε2 seems to confer protection. Here, we report that healthy young carriers have statistically significantly smaller hippocampal volumes than carriers, while no differences were detected between two groups in memory performance. difference morphology cognitively/clinically silent adulthood, but could render more prone later AD possibly due lower...
Gait-related symptoms are often refractory to current available treatment options with a significant reduction in quality of life Parkinson's disease.The objective this study was determine the long-term efficacy and safety unilateral pedunculopontine area stimulation for gait balance impairment disease.This used periodic randomized double-blinded assessments until 4 years postoperatively. The primary outcomes were gait-related items UPDRS part II MDS-UPDRS III.At baseline, median age disease...
ABSTRACT Background To report on the clinical efficacy of bilateral globus pallidus internus deep brain stimulation in a 29‐year‐old patient with severe generalized dystonia secondary to Wilson's disease. Methods The primary outcome measure was Burke‐Fahn‐Marsden Dystonia Scale motor severity score (blinded assessment) and measures were Abnormal Involuntary Movement Zaritt Caregiver Burden Interview score, at 20‐week postoperative follow up. Results There 14% improvement score. remained...
Abstract Patients with dystonia are particularly appropriate for diagnostic exome sequencing (DES), due to the complex, diverse features and genetic heterogeneity. Personal family history data were collected from test requisition forms medical records 189 patients reported available members received clinical DES. Of them, 20.2% had a positive finding associated dystonia. Detection rates cases isolated combined 22.4% 25.0%, respectively. 71.4% of cohort co‐occurring non‐movement‐related...
Hypokinetic dysarthria and dysphagia are known features of Parkinson's disease; however, self-perception their handicapping effects on emotional, physical, functional aspects quality life over disease duration is less understood.1) Based upon patient self-perception, to determine the relationship dysphonia with time since diagnosis in individuals 2)To if there a between voice swallowing handicap throughout course disease.277 subjects completed Dysphagia Handicap Index Voice Index. Subjects...