A5044505278- Traumatic Brain Injury Research
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Psychosomatic Disorders and Their Treatments
- Bioinformatics and Genomic Networks
- Cardiac Arrest and Resuscitation
- Cerebrovascular and Carotid Artery Diseases
- Genetic Associations and Epidemiology
- Cerebrospinal fluid and hydrocephalus
- Cardiovascular Effects of Exercise
- Health, Environment, Cognitive Aging
- Statistical Methods in Clinical Trials
- Brain Tumor Detection and Classification
- Occupational Health and Performance
- Acute Ischemic Stroke Management
- Suicide and Self-Harm Studies
- Machine Learning in Healthcare
- Neurological Disorders and Treatments
- Machine Learning in Bioinformatics
- Neuroinflammation and Neurodegeneration Mechanisms
Cleveland Clinic
2016-2025
Lou Ruvo Brain Institute
2016-2025
University of Washington
2004-2025
Mayo Clinic in Arizona
2021-2025
University of Pennsylvania
2004-2024
Johns Hopkins Medicine
2024
Johns Hopkins University
2001-2024
University of Florida
2024
University of Connecticut
2024
Boston University
2021-2024
A randomized, placebo-controlled, double-blind, multicenter 52-week phase 2 trial of resveratrol in individuals with mild to moderate Alzheimer disease (AD) examined its safety and tolerability effects on biomarker (plasma Aβ40 Aβ42, CSF Aβ40, tau, phospho-tau 181) volumetric MRI outcomes (primary outcomes) clinical (secondary outcomes).
<i>Background:</i> Silent infarcts are commonly discovered on cranial MRI in the elderly. <i>Objective:</i> To examine association between risk of stroke and presence silent infarcts, alone combination with other factors. <i>Methods:</i> Participants (3,324) Cardiovascular Health Study (CHS) without a history underwent scans 1992 1994. were defined as focal lesions greater than 3 mm that hyperintense T2 images and, if subcortical, hypointense T1 images. Incident strokes identified classified...
Background and Purpose— We have previously reported that several “silent” infarcts found on magnetic resonance imaging (MRI) were a risk factor for stroke. Several recent reports shown high white matter grade (WMG) increasing WMG over time factors tested the hypothesis ≥2 was predictor of stroke, independent other factors. Methods— examined extent hyperintensity cranial MRI 3293 participants from Cardiovascular Health Study (CHS). The degree graded least severe (grade=0) to most (grade=9)....
Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) reduce cardiovascular risk through mechanisms that might affect the development of dementia.To evaluate whether statin use is associated with a lower dementia compared never lipid-lowering agents (LLAs).Cohort study community-dwelling adults 65 years and older. The analysis included 2798 participants free at baseline.Using Cox proportional hazards regression analysis, we estimated incident all-cause type-specific...
Few population-based studies have examined in detail issues of stroke-related deaths elderly people.Participants the Cardiovascular Health Study (CHS) are 65 years age or older, had extensive baseline evaluations, and been followed-up for fatal nonfatal cardiovascular cerebrovascular disease outcomes. Investigators adjudicated these outcomes classified strokes by types subtypes.Over 7 years, 1,310 (22.2%) 5,888 participants died, 455 (7.7%) experienced incident stroke. For 5,888, stroke...
The ε4 allele of the apolipoprotein E (APOE) gene is major genetic risk factor for Alzheimer’s disease (AD), but limited work has suggested that APOE genotype may modulate phenotype. Carriers have been reported to greater medial temporal lobe (MTL) pathology and poorer memory than noncarriers. Less attention focused on whether there are domains cognition neuroanatomical regions more affected in Further, a potential confound prior vivo studies possibility different rates clinical misdiagnosis...
Abstract Introduction This clinical trial evaluates the efficacy and safety of a 6‐week course daily neuroAD™ therapy. Methods 131 subjects between 60 90 years old, unmedicated for Alzheimer's disease (AD), or on stable doses an acetylcholinesterase inhibitor and/or memantine, with Mini–Mental State Examination scores 18 26, dementia rating scale 1 2, enrolled prospective, randomized, double‐blind, sham‐controlled, multicenter trial. Structural brain MRIs were obtained transcranial magnetic...
<h3>Objective:</h3> We tested biweekly infusions of IV immunoglobulin (IVIg) as a possible treatment for mild to moderate Alzheimer disease (AD) dementia. <h3>Methods:</h3> In phase 3, double-blind, placebo-controlled trial, we randomly assigned 390 participants with AD receive placebo (low-dose albumin) or IVIg (Gammagard Liquid; Baxalta, Bannockburn, IL) administered at doses 0.2 0.4 g/kg every 2 weeks 18 months. The primary cognitive outcome was change from baseline months on the 11-item...
Cumulative head trauma may alter brain structure and function. We explored the relationship between exposure variables, cognition MRI structural measures in a cohort of professional combatants.224 fighters (131 mixed martial arts 93 boxers) participating Professional Fighters Brain Health Study, longitudinal study licensed combatants, were recruited, as 22 controls. Each participant underwent computerised cognitive testing volumetric MRI. Fighting history including years fighting fights per...
<b>Objective: </b> To examine the association of statin drug use on cognitive and MRI change in older adults. <b>Methods: Participants Cardiovascular Health Study, a longitudinal study people age 65 or older, were classified into three groups determined by whether they taking drugs continuous basis, intermittently, not at all. The untreated group was further divided categories based National Cholesterol Education Program recommendations for lipid-lowering treatment. with prevalent incident...
Cerebral microvascular disease may be a risk factor for the development of dementia in elderly persons. We describe association retinal signs with cognitive function and among older individuals.In population-based Cardiovascular Health Study, 2211 persons aged 69 to 97 years at recruitment had photography. Photographs were evaluated retinopathy (eg, microaneurysms, hemorrhages), focal arteriolar narrowing, arteriovenous nicking, venular caliber. Cognitive status was determined from...
Traumatic brain injury is common in fighting athletes such as boxers, given the frequency of blows to head. Because DTI sensitive microstructural changes white matter, this technique often used investigate matter integrity patients with traumatic injury. We hypothesized that previous fight exposure would predict abnormalities after controlling for individual variation.A total 74 boxers and 81 mixed martial arts fighters were included analysis scanned by use DTI. Individual information data...
Repetitive head trauma is a risk factor for Alzheimer's disease and the primary cause of chronic traumatic encephalopathy. However, little known about natural history of, factors for, encephalopathy or means early detection intervention. The Professional Fighters Brain Health Study longitudinal study active professional fighters (boxers mixed martial artists), retired fighters, controls matched age level education. main objective to determine relationships between measures exposure other...
Factors that affect the rate of progression Alzheimer disease (AD) need to be considered in clinical trial designs potential disease-modifying therapies.To determine influence age on AD course a setting.Pooled cohort study from 3 trials 18-month duration conducted by Disease Cooperative Study group.Alzheimer research centers across United States.Four hundred seventy-one subjects with mild moderate assigned placebo arm trials.The relationships between baseline and change Assessment...
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that has been neuropathologically diagnosed in brain donors exposed to repetitive head impacts, including boxers and American football, soccer, ice hockey, rugby players. CTE cannot yet be during life. In December 2015, the National Institute of Neurological Disorders Stroke awarded seven-year grant (U01NS093334) fund "Diagnostics, Imaging, Genetics Network for Objective Study Evaluation Traumatic Encephalopathy (DIAGNOSE...
Abstract Background Patterns of cognitive impairment in former American football players are uncertain because objective neuropsychological data lacking. This study characterized the test performance college and professional players. Methods One hundred seventy male ( n =111 professional, =59 college; 45–74 years) completed a battery. Raw scores were converted to T -scores using age, sex, education-adjusted normative data. A -score ≤ 35 defined impairment. domain was impaired if 2+ fell...
The aim of this study is to evaluate longitudinal change in plasma neurofilament light (NF-L) and tau levels relationship clinical radiological measures professional fighters. Participants (active retired fighters control group) underwent annual blood sampling, 3-Tesla magnetic resonance imaging (MRI) brain imaging, computerized cognitive testing, assessment exposure traumatic injury. Plasma NF-L concentrations were measured using Simoa assays. Multiple linear regression models used compare...