A5008972289- Carbohydrate Chemistry and Synthesis
- Cholinesterase and Neurodegenerative Diseases
- Organoselenium and organotellurium chemistry
- Glycosylation and Glycoproteins Research
- Dementia and Cognitive Impairment Research
- Computational Drug Discovery Methods
- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Alzheimer's disease research and treatments
- Synthesis and Catalytic Reactions
- Enzyme function and inhibition
- Synthesis of Organic Compounds
- Enzyme Catalysis and Immobilization
- Chemical Synthesis and Reactions
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Lysosomal Storage Disorders Research
- Phytochemicals and Antioxidant Activities
- Edible Oils Quality and Analysis
- Polyamine Metabolism and Applications
- Enzyme Production and Characterization
- Free Radicals and Antioxidants
- Chemical Reactions and Mechanisms
- Vanadium and Halogenation Chemistry
- Selenium in Biological Systems
Universidad de Sevilla
2016-2025
University of Pittsburgh
2011-2025
Worcester Polytechnic Institute
2022
Karlsruhe Institute of Technology
2022
University of Coimbra
2022
University of L'Aquila
2022
RISE Research Institutes of Sweden
2022
University of Évora
2022
Georgetown University
2022
Rede de Química e Tecnologia
2011-2021
The environmentally amiable route to carbon-heteroatom bond formation, described by Sharpless as 'click chemistry', has become known a fast, efficient, and reliable approach the synthesis of novel compounds with desired functionalities. Readily available starting materials must be used in this methodology they should essentially inert most biological organic conditions, including water molecular oxygen. In review, we cover reactions included label such cycloadditions, nucleophilic...
To examine whether the use of psychiatric medication and presence abnormal behaviors affects progression Alzheimer disease.Cross-sectional with longitudinal follow-up likelihood arriving at 4 end points: (1) Mini-Mental State Examination score 9 or lower; (2) Blessed Dementia Rating Scale 15 higher for activities daily living; (3) nursing home admission; (4) death, evaluated using a proportional hazard model variables: psychosis, insomnia, wandering, aggression, psychomotor agitation,...
Hydroxytyrosol is a phenol found predominantly in the olive tree (Olea europea). It shows broad spectrum of beneficial effects such as cancer chemoprevention by inducing apoptosis, cardioprotection and anti-atherogenic activity, skin photoprotection anti-inflammatory activity. These biological properties are based on scavenging reactive oxygen species hydroxytyrosol, being more active than antioxidant vitamins synthetic antioxidants. Its activities human health has stimulated development new...
Insecticides have a pivotal role in our lives, not only for crop protection agriculture, but also to avoid the spreading of harmful pests causing human diseases such as malaria. Due economic and medical reasons, design effective agents that control these is quite an important task agrochemical science industrial sector. Nevertheless, non-restricted use highly toxic insecticides several decades has provoked negative effects environment poisoning non-targeted species. For development selective...
Starting from natural steroids (diosgenin, hecogenin, smilagenin, estrone), we have prepared a wide panel of selenoderivatives, including benzoselenazolones, selenosemicarbazones, isoselenocyanates, selenoureas, selenocyanates and diselenides, with the aim developing new families potential chemotherapeutic agents. The modification organoselenium moieties, their position on steroid provided valuable information concerning antiproliferative activities. Among all accessed herein, best profile...
Being aware of the need to develop more efficient therapies against cancer, herein we disclose an innovative approach for design selective antiproliferative agents. We have accomplished conjugation a coumarin fragment with lipophilic cations (triphenylphosphonium salts, guanidinium) providing mitochondriotropic agents that simultaneously target also carbonic anhydrases IX and XII, involved in development progression cancer. The new compounds prepared turned out be strong inhibitors XII human...
Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro no neurotoxicity.
Abstract New conformationally‐restricted steroids were synthesized by incorporating a spiranic heterocyclic motif at the C‐17 position, using trans ‐androsterone, ‐dehydroandrosterone, and estrone as starting materials. A cyclocondensation process with o ‐disubstituted aromatic bis ‐nucleophiles enabled modification of structure. In silico calculations employed to predict diastereoselectivity assignment new chiral center stereochemistry. Spiranic derivatives evaluated in vitro for...
The selective inhibition of key enzymes, such as carbonic anhydrases (CAs IX and XII), which are overexpressed in cancer tissues, has emerged a promising strategy research. However, multitarget approach is often preferred to achieve enhanced therapeutic outcomes. In this study, aryl sulfonamides were conjugated with thiosemicarbazone moiety enable dual functionality: the CAs chelation metal cations. Several structural factors systematically modified, including position sulfonamido group,...
Atypical frontotemporal lobar degeneration with ubiquitin-positive inclusions (aFTLD-U) is a rare subtype of Frontotemporal Lobar Degeneration. aFTLD-U reported typically young onset behavioral variant dementia syndrome, more specifically younger age, predominant hyperorality, obsessive-compulsive features, and severe caudate atrophy. Very few cases have been prominent language impairment no major features. We present another such case presenting adding to the phenotypic spectrum, deficits...
The synthesis of an isofagomine analogue with amidine group in the 1,6-position is described. Density functional theory calculations showed that this compound has a remarkably different charge distribution compared isofagomine. This may explain why poor glycosidase inhibitor (IC 50 > µM against all tested enzymes)
Abstract INTRODUCTION Proteomic evaluation of plasma samples could accelerate the identification novel Alzheimer's disease (AD) biomarkers. We evaluated NUcleic acid Linked Immuno‐Sandwich Assay (NULISA) proteomic method in an ethnically diverse cohort. METHODS Plasma biomarkers were measured with NULISA Human Connectome Project, a predominantly preclinical biracial community cohort southwestern Pennsylvania. Selected additionally using Simoa and Quest immunoassays compared. RESULTS On...
The effect of conformation on glycoside reactivity was investigated by studying the hydrolysis a selection 3,6-anhydroglucosides as models for glucose in highly reactive 1C4 conformation. Methyl 3,6-anhydro-β-d-glucopyranoside found to hydrolyze 200−400 times faster than methyl glucosides 4C1 conformation, while 3,6-anhydro-β-d-galactopyranoside, which is B1,4 less β-d-galactopyranoside. (3,6-anhydro-β-d-glucopyranosyl)-(1 → 6)-α-d-glucopyranoside, (3,6-anhydro-α-d-glucopyranosyl)-(1...