A5090885975- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Fungal Biology and Applications
- Organoselenium and organotellurium chemistry
- Synthesis and Biological Evaluation
- Cholinesterase and Neurodegenerative Diseases
- Microbial Natural Products and Biosynthesis
- Essential Oils and Antimicrobial Activity
- Free Radicals and Antioxidants
- Photodynamic Therapy Research Studies
- Crystallography and molecular interactions
- Plant Pathogens and Fungal Diseases
- Organic Chemistry Cycloaddition Reactions
- Antioxidant Activity and Oxidative Stress
- Skin Protection and Aging
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- TGF-β signaling in diseases
- Catalytic C–H Functionalization Methods
- Pesticide Exposure and Toxicity
- Fermentation and Sensory Analysis
- Genomics, phytochemicals, and oxidative stress
Universidad Veracruzana
2015-2024
Universidad de La Laguna
2016-2023
Laguna Research
2016-2018
Institute of Organic Chemistry
2016-2018
Hospital Universitario Dr José Eleuterio Gonzalez
2017
Observatorio de la Inmigración de Tenerife
2017
<p><strong>Background. </strong>The central zone of Veracruz state in Mexico, includes areas cloud forest which some microbial interactions such as insect-associated fungi can be found, like <em>Isaria</em>, <em>Paraisaria</em>, <em>Ophiocordyceps</em>, <em>Paecilomyces </em>and <em>Cordyceps </em>genera. <strong>Objective</strong>. To isolate entomopathogenic from the and determine their antioxidant...
Abstract In this study, we explored the catalyst‐free one‐pot multi‐component synthesis of 1,4‐dihydropyridine derivatives by following green chemistry protocol. The present approach shows significant outcomes such as yield up to 94%, reaction, easy workup procedure and shorter period reaction time. work also highlighted comparison yields obtained under both neat solvent media well. anti‐proliferative activity all newly synthesized compounds has been assessed against six human solid tumor...
Inspired by marine bioactive compounds, the principle of molecular hybridization was applied combining diverse heterocyclic systems a triazole ring, to produce new and more active compounds.
Every year, more than 500,000 new cases of cervical cancer are reported, making it the fourth leading cause globally. Although human papillomavirus (HPV) vaccines show promise as a protective measure, HPV-related cancers remain public health problem since vaccines, which only specific to certain viral types, unavailable for mass distribution. Furthermore, effects toxicity following ionizing radiation therapy have reoriented views toward search radiosensitizers that can reduce consequence...
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer's agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with catalytic anionic site (CAS); a hydrocarbon tether variable lengths, and fragment derived from 2-phenylethanol promoting interactions peripheral (PAS). Title compounds exhibited good selectivity towards BuChE, strongly depending substitution pattern length tether. The lead were...
Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite vast number cytotoxic agents developed so far, good therapeutic approaches are not always reached. In recent years, multitarget drugs gaining great attention against in contraposition polypharmacy. Herein we have accomplished conjugation phenolic derivatives with an ample organochalcogen motifs aim developing novel antiproliferative agents. Their antioxidant, and properties (against six...
The synthesis of new carbohydrate-derived 3-nitro-2<italic>H</italic>-thiochromenes with potential antiproliferative activity is described.
Being aware of the enormous biological potential organoselenium and polyphenolic compounds, we have accomplished preparation novel hybrids, combining both pharmacophores in order to obtain new antioxidant antiproliferative agents. Three different families been accessed a straightforward chemoselective fashion: carbohydrate-containing N-acylisoselenoureas, N-arylisoselenocarbamates N-arylselenocarbamates. The nature framework, number position phenolic hydroxyl groups substituents on aromatic...
Moderate consumption of red wine provides beneficial effects to health. This is attributed polyphenol compounds present in such as resveratrol, quercetin, gallic acid, rutin, and vanillic acid. The amount these antioxidants variable; nevertheless, the main are resveratrol. However, it has been found that resveratrol quercetin able photosensitize singlet oxygen generation conversely, acid acts quencher. Therefore, since some most important reported wines, aim this research was evaluate...
Heterocycles of this series resemble MDM2 inhibitors.
Marine ecosystems are unique and rich reservoirs of biodiversity with high potential toward improving the quality human life. The extreme physical–chemical conditions oceans have favored marine organisms to produce a great variety new molecules as mechanism ensure their survival, such compounds possess biopharmaceutical interest. In particular, microbiota represent promising inexhaustible source for development drugs. This work presents taxonomic study samples obtained from underwater...
Background: Fungi from mangrove forests represent a great potential for the bioprospecting of new bioactive metabolites. The rhizosphere several regions world has been widely studied, however, there are no studies on biodiversity Mexican mangroves.Objectives: To evaluate anti-proliferative activity fungal extracts isolated accumulated sediments in three species distributed zones with different degrees salinity Mexico.Methods: fungi were identified at genus level by taxonomic keys. was...
Polyporoid fungi represent a vast source of bioactive compounds with potential pharmacological applications. The importance polyporoid in traditional Chinese medicine has led to an extensive use some species <i>Ganoderma </i>for promoting health and longevity because their consumption is associated several bioactivities. Nevertheless, bioactivity other members the Polyporaceae family also been reported. This work reports antiproliferative antibacterial activity crude extracts...