A5005027591- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Chemical Synthesis and Reactions
- Oxidative Organic Chemistry Reactions
- Marine Sponges and Natural Products
- Marine Toxins and Detection Methods
- Catalytic Alkyne Reactions
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Traditional and Medicinal Uses of Annonaceae
- Carbohydrate Chemistry and Synthesis
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Asymmetric Hydrogenation and Catalysis
- Cyclopropane Reaction Mechanisms
- Click Chemistry and Applications
- Inorganic and Organometallic Chemistry
- Synthesis and biological activity
- Analytical Chemistry and Chromatography
- Chemical Reaction Mechanisms
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Catalytic Reactions
- Seaweed-derived Bioactive Compounds
- Phosphorus compounds and reactions
Universidad de Navarra
2024
Universitat Autònoma de Barcelona
2022-2024
Universitat Politècnica de Catalunya
2022-2024
Agostino Gemelli University Polyclinic
2023
Helsinki University Hospital
2023
Technical University of Munich
2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2023
Fundación Instituto Valenciano de Oncología
2023
Aristotle University of Thessaloniki
2023
Hospital Infantil Universitario Niño Jesús
2023
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA greatly improved procedure for ruthenium tetroxide catalyzed oxidations of organic compoundsPer H. J. Carlsen, Tsutomu Katsuki, Victor S. Martin, and K. Barry SharplessCite this: Org. Chem. 1981, 46, 19, 3936–3938Publication Date (Print):September 1, 1981Publication History Published online1 May 2002Published inissue 1 September 1981https://pubs.acs.org/doi/10.1021/jo00332a045https://doi.org/10.1021/jo00332a045research-articleACS...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic resolution of racemic allylic alcohols by enantioselective epoxidation. A route to substances absolute enantiomeric purity?Victor S. Martin, Scott Woodard, Tsutomu Katsuki, Yasuhiro Yamada, Masonari Ikeda, and K. Barry SharplessCite this: J. Am. Chem. Soc. 1981, 103, 20, 6237–6240Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of saccharides and related polyhydroxylated natural products. 1. Simple alditolsT. Katsuki, A. W. M. Lee, P. Ma, V. S. Martin, Masamune, K. B. Sharpless, D. Tuddenham, F. J. WalkerCite this: Org. Chem. 1982, 47, 7, 1373–1378Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/jo00346a051https://doi.org/10.1021/jo00346a051research-articleACS...
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEfficient oxidation of phenyl groups to carboxylic acids with ruthenium tetraoxide. A simple synthesis (R)-.gamma.-caprolactone, the pheromone Trogoderma granariumM. Teresa Nunez and Victor S. MartinCite this: J. Org. Chem. 1990, 55, 6, 1928–1932Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of saccharides and related polyhydroxylated natural products. 2. Simple deoxyalditolsP. Ma, V. S. Martin, Masamune, K. B. Sharpless, M. VitiCite this: J. Org. Chem. 1982, 47, 7, 1378–1380Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/jo00346a052https://doi.org/10.1021/jo00346a052research-articleACS PublicationsRequest reuse...
Computational design of protein-binding proteins is a fundamental capability with broad utility in biomedical research and biotechnology. Recent methods have made strides against some target proteins, but on-demand creation high-affinity binders without multiple rounds experimental testing remains an unsolved challenge. This technical report introduces AlphaProteo, family machine learning models for protein design, details its performance on the de novo binder problem. With we achieve 3- to...
[reaction: see text] A new iron(III) halide-promoted aza-Prins cyclization between gamma,delta-unsaturated tosylamines and aldehydes provides six-membered azacycles in good to excellent yields. The process is based on the consecutive generation of gamma-unsaturated-iminium ion further nucleophilic attack by unsaturated carbon-carbon bond. Homoallyl tosylamine leads trans-2-alkyl-4-halo-1-tosylpiperidine as major isomer. In addition, alkyne homopropargyl gives...
A new Prins cyclization process that builds up one carbon−carbon bond, heteroatom-carbon and halogen-carbon (in an oxa- azacycle) relies on iron catalyst system formed from Fe(acac)3 trimethylsilyl halide. The method displays a broad substrate scope is economical, environmentally friendly, experimentally simple. This catalytic permits the construction of chloro, bromo iodo heterocycles, by suitable combination iron(III) source, corresponding halide solvent, in high yields.
Iron (III) chloride is extensively used in organic synthesis as an ideal Lewis acid since it inexpensive, efficient, stable, environmentally friendly and a convenient agent for several useful reactions such as; polymerisations, oxidations, oxidative couplings, reductions, C bond formation, Ferrier rearrangement, one-pot multicomponent condensations, Friedel-Crafts reactions, cyclisations, glycosidation, Prins-type cyclisation, deprotection of various functional groups, reagent key steps...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneral method for determining absolute configuration of acyclic allylic alcoholsNina C. Gonnella, Koji Nakanishi, Victor S. Martin, and K. Barry SharplessCite this: J. Am. Chem. Soc. 1982, 104, 13, 3775–3776Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June 1982https://pubs.acs.org/doi/10.1021/ja00377a063https://doi.org/10.1021/ja00377a063research-articleACS PublicationsRequest reuse...
'Onium' compounds, including ammonium and phosphonium salts, have been employed as antiseptics disinfectants. These cationic biocides incorporated into multiple materials, principally to avoid bacterial attachment. In this work, we selected 20 alkyl-triphenylphosphonium differing mainly in the length functionalization of their alkyl chains, fulfilment two main objectives: 1) provide a comprehensive evaluation antifouling profile these molecules with relevant marine fouling organisms; 2) shed...
In flares of systemic lupus erythematosus (SLE), endothelial cells (EC; activated by immune stimuli) are potential participants in the inflammatory processes that contribute to tissue damage. Accordingly, elevated levels circulating (CEC) may be a marker for vascular injury. This study was undertaken examine possibility stimulated EC found circulation patients with active SLE.The cohort included 38 SLE and 16 healthy controls. Immunostaining performed on mononuclear isolates, using mouse...
[reaction: see text] A new Prins-type cyclization between homopropargylic alcohol and aldehydes in the presence of FeX(3) to obtain 2-alkyl-4-halo-5,6-dihydro-2H-pyrans good yield is described. Osmium-catalyzed cis dihydroxylation provided direct access trans-2-alkyl-3-hydroxy-tetrahydro-pyran-4-ones. Anhydrous ferric halides are also shown be excellent catalysts for standard Prins using homoallylic alcohol. Isolation an intermediate acetal provides substantiation a proposed mechanism.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of saccharides and related polyhydroxylated natural products. 3. Efficient conversion 2,3-erythro-aldoses to 2,3-threo-aldosesAlbert W. M. Lee, Victor S. Martin, Satoru Masamune, K. Barry Sharpless, Frederick J. WalkerCite this: Am. Chem. Soc. 1982, 104, 12, 3515–3516Publication Date (Print):June 1, 1982Publication History Published online1 May 2002Published inissue 1 June...
In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out their potent at concentrations 500 to 50 μg mL−1. The molecular characterization, based on the internal transcribed spacer (ITS) region sequences (ITS1, 5.8S ITS2) between rRNA 18S 28S, identified these as...
Ascorbate and catalytic amounts of menadione transform atmospheric oxygen into hydrogen peroxide which is able to carry out oxidation.
Gallic acid is able to catalyse radical C–H arylations of (hetero)arenes with diazonium salts at room temperature in water–acetone. As gallic present multiple bio-wastes, this methodology unleashes an alternative method for waste reutilization.
Iron(III) halides have proven to be excellent catalysts in the coupling of acetylenes and aldehydes. When terminal were used main products obtained 1,5-dihalo-1,4-dienes with (E,Z)-stereochemistry contaminated some cases (E)-alpha,beta-unsaturated ketones. The former carbonyl derivatives sole isolated when nonterminal aromatic alkynes used. homopropargylic alcohols used, a Prins-type cyclization occurred yielding 2-alkyl-4-halo-5,6-dihydro-2H-pyrans. In addition, anhydrous ferric are also...
The stereoselective formation of chiral tertiary alcohols is great importance for the synthesis enantiomerically pure natural products and pharmaceuticals. simplest approach preparation enantioselective addition organometallic reagents to carbonyl compounds. Hundreds catalysts promote nucleophilic additions compounds aldehydes with high enantioselectivities. However, use ketones as group acceptors under similar conditions has proven much more challenging. chemistry catalytic asymmetric...
Abstract A series of functionalized tetrahydropyran and dihydropyran derivatives was synthesized by means a Prins‐type cyclization between unsaturated alcohols several aldehydes. An unprecedented dimer bearing two 4‐chloro‐5,6‐dihydro‐2 H ‐pyran scaffolds obtained in high yield. panel three representative human solid tumor cells from diverse origin used to assess the cytotoxicity compounds. Overall, results show relevance chlorovinyl group biological activity, 2‐alkyl‐4‐chloro‐5,6‐dihydro‐2...
Good things come in small interactions: The high chiral discrimination displayed by a new receptor with ammonium salts of aromatic α-amino acid methyl esters is mainly the result one weakest noncovalent interactions, CH–π interaction (see picture). has been identified and quantified, its contribution to recognition process evaluated. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made...