A5033307882- Marine Toxins and Detection Methods
- Seaweed-derived Bioactive Compounds
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Chemical synthesis and alkaloids
- Marine and coastal plant biology
- Algal biology and biofuel production
- Protist diversity and phylogeny
- Marine and coastal ecosystems
- Molecular spectroscopy and chirality
- Synthetic Organic Chemistry Methods
- Food Industry and Aquatic Biology
- Vanadium and Halogenation Chemistry
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Echinoderm biology and ecology
- Biological Activity of Diterpenoids and Biflavonoids
- Hemoglobin structure and function
- Medicinal plant effects and applications
- Marine Biology and Environmental Chemistry
- Redox biology and oxidative stress
- Organic and Inorganic Chemical Reactions
- Fungal Biology and Applications
- X-ray Diffraction in Crystallography
- Alcohol Consumption and Health Effects
Universidad de La Laguna
2012-2023
Universidad de Oviedo
2014
Tokushima Bunri University
2008
Instituto de Investigacións Mariñas
2005
Centro de Investigaciones Científicas Isla de la Cartuja
2003
Consejo Superior de Investigaciones Científicas
1987-1996
Istanbul University
1991
Columbia University
1989
Instituto de Productos Naturales y Agrobiología
1982-1983
Yessotoxin (YTX) is a marine polyether toxin that was first isolated in 1986 from the scallop Patinopecten yessoensis. Subsequently, it reported YTX produced by dinoflagellates Protoceratium reticulatum, Lingulodinium polyedrum and Gonyaulax spinifera. YTXs have been associated with diarrhetic shellfish poisoning (DSP) because they are often simultaneously extracted DSP toxins, give positive results when tested conventional mouse bioassay for toxins. However, recent evidence suggests should...
The first page of this article is displayed as the abstract.
'Onium' compounds, including ammonium and phosphonium salts, have been employed as antiseptics disinfectants. These cationic biocides incorporated into multiple materials, principally to avoid bacterial attachment. In this work, we selected 20 alkyl-triphenylphosphonium differing mainly in the length functionalization of their alkyl chains, fulfilment two main objectives: 1) provide a comprehensive evaluation antifouling profile these molecules with relevant marine fouling organisms; 2) shed...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthesis of saxitoxin analogs: the unexpected pathwayYuzuru Shimizu, Manuel Norte, Akira Hori, Almoursi Genenah, and Masaru KobayashiCite this: J. Am. Chem. Soc. 1984, 106, 21, 6433–6434Publication Date (Print):October 1, 1984Publication History Published online1 May 2002Published inissue 1 October 1984https://pubs.acs.org/doi/10.1021/ja00333a062https://doi.org/10.1021/ja00333a062research-articleACS PublicationsRequest reuse permissionsArticle...
Abstract Five‐membered rings are clearly among the most common structural motifs found in chemistry and biology. Nevertheless, configuration of conformationally mobile five‐membered is often difficult to assign from nuclear magnetic resonance (NMR) data. A simple, reliable, efficient approach for stereochemical analysis based on measurement NMR coupling constants presented. Density functional theory calculations using representative conformations full conformational space available with...
In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out their potent at concentrations 500 to 50 μg mL−1. The molecular characterization, based on the internal transcribed spacer (ITS) region sequences (ITS1, 5.8S ITS2) between rRNA 18S 28S, identified these as...
The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety organisms that offer biological and chemical diversity with metabolic abilities unrivalled terrestrial systems, which makes them an attractive target bioprospecting as almost untapped resource biotechnological applications. Among them, there is no doubt microalgae could become genuine "cell factories" the synthesis substances. Thus, course inter-laboratory...
Belizentrin (1), a novel 25-membered polyketide-derived macrocycle, was isolated from cultures of the marine dinoflagellate Prorocentrum belizeanum. This metabolite is first member an unprecedented class polyunsaturated and polyhydroxylated macrolactams. The structure 1 primarily determined by NMR computational methods. Pharmacological assays with cerebellar cells showed that produces important changes in neuronal network integrity at nanomolar concentrations.
Abstract The structural determination of small organic molecules is mainly undertaken by using NMR techniques, although it increasingly supplemented computational methods. parameters, such as chemical shifts and coupling constants, are extremely sensitive indicators local molecular conformation a source evidence. However, their interpretation fairly challenging in many circumstances, the case new polyether squalene derivative nivariol, structure which was elucidated means spectroscopy DFT...
The chemical study of the red alga Laurencia viridis has led to isolation four new polyether triterpenoids: 28-hydroxysaiyacenol B (2), saiyacenol C (3), 15,16-epoxythyrsiferol A (4), and (5). structures 2 3 were established mainly by NMR data analysis comparison with well-known metabolite dehydrothyrsiferol (1). However, due existence a nonprotonated carbon within epoxide functionality, stereochemical assignments in 4 5 required an in-depth structural that included NOESY data, J-based...
A variety of conditions (culture media, inocula, incubation temperatures) are employed in antifouling tests with marine bacteria. Shewanella algae was selected as model organism to evaluate the effect these parameters on: bacterial growth, biofilm formation, activity antifoulants, and development nanomechanical properties biofilms. The main objectives were: 1) To highlight quantify on relevant for studies: morphology, thickness, roughness, surface coverage, elasticity adhesion forces. 2)...
A new protein phosphatase inhibitor, 19-epi-okadaic acid, was isolated from the marine dinoflagellate Prorocentrum belizeanum. Its structure and conformation in solution has been determined, important differences were found when compared with lead compound okadaic acid. The metabolite showed nanomolar activities, its selectivity for PP2A versus PP1 surpasses that shown by acid 10-fold, making it one of most selective inhibitors this class.
An exclusive club: The first member of an unprecedented class polyunsaturated and polyhydroxylated macrocycle, belizeanolide (see structure), has been isolated from a marine dinoflagellate. corresponding open form, belizeanolic acid, was also found. Their structures were determined primarily by analysis NMR spectroscopic data. Both compounds showed significant antiproliferative activities. Detailed facts importance to specialist readers are published as "Supporting Information". Such...