A5053892827- Physics of Superconductivity and Magnetism
- Magnetic properties of thin films
- Natural product bioactivities and synthesis
- X-ray Diffraction in Crystallography
- Monoclonal and Polyclonal Antibodies Research
- Crystallization and Solubility Studies
- RNA Interference and Gene Delivery
- Marine Sponges and Natural Products
- Ubiquitin and proteasome pathways
- Biochemical and Molecular Research
- Seaweed-derived Bioactive Compounds
- Drug Transport and Resistance Mechanisms
- Glycosylation and Glycoproteins Research
- Cancer-related Molecular Pathways
- Adenosine and Purinergic Signaling
- Phytochemistry and Biological Activities
- Inflammatory Bowel Disease
- Metal complexes synthesis and properties
- Quantum and electron transport phenomena
- Natural Compounds in Disease Treatment
- Iron-based superconductors research
- Immune Cell Function and Interaction
- Rare-earth and actinide compounds
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
Centre National de la Recherche Scientifique
2015-2025
Kliniken Essen-Mitte
2018-2025
Université de Strasbourg
2016-2025
Laboratoire d'Innovation Thérapeutique
2009-2025
Otto-von-Guericke University Magdeburg
2010-2024
Institut Pluridisciplinaire Hubert Curien
2012-2024
University Hospital Magdeburg
2024
Laboratoire de Biophotonique et Pharmacologie
1996-2022
Physique des interactions ioniques et moléculaires
2021
University Hospital of Basel
2020
Mycophenolic acid (MPA), an inhibitor of inosine monophosphate dehydrogenase, in nanomolar concentrations blocks proliferative responses cultured human, mouse and rat T lymphocytes B to mitogens or mixed lymphocyte reactions. The inhibitory effect MPA on proliferation is reversed by addition culture media deoxyguanosine guanosine but not deoxyadenosine adenosine. findings suggest that the principal mechanism action low depletion triphosphate which required for DNA synthesis. In...
Herein, we developed the first ratiometric fluorescent probe for apoptosis detection. This incorporates selectively into outer leaflet of cell plasma membrane and senses loss asymmetry occurring during early steps apoptosis. The high specificity to membranes was achieved by introduction a anchor, composed zwitterionic group long (dodecyl) hydrophobic tail. fluorescence reporter this is 4'-(diethylamino)-3-hydroxyflavone, which exhibits excited-state intramolecular proton transfer (ESIPT),...
ABSTRACT Essential oils are gaining increasing interest for their antimicrobial and antiviral properties, as well preventive therapeutic actions against many human pathologies. Herein, we present an overview on new discoveries in essential oil research, discussing activity, immunomodulatory, anti‐apoptotic, anti‐angiogenic anti‐tumoural properties. In addition, emphasize recent advances the identification of bioactive components understanding mechanism action. We discuss molecular diversity...
BACKGROUND: Increasing evidence points to a important role for inflammatory cytokines the pathogenesis of Crohn9s disease. AIM: To compare secretion rate tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) by morphologically normal inflamed intestinal mucosa from patients with RESULTS: Organ cultures biopsy specimens taken areas affected disease spontaneously produced increased amounts TNF-alpha, IL-1 beta, IL-6 compared controls but also in...
The bcl-2 oncoprotein confers a survival advantage to cells by inhibiting programmed cell death (PCD) or apoptosis. Overexpression of probably plays role in colorectal carcinogenesis. aims our study were determine expression and PCD index adenomas carcinomas correlation with p53 expression, Ki-67 index, histopathology, test their prognostic significance patients carcinomas.Immunohistologic staining for (MoAb clone 124), the proliferation-associated antigen MIB1), DO1) was performed on...
Abstract Objectives Flavonoids are phenolic compounds found in most edible fruits and vegetables. Previous studies have demonstrated their biological beneficial effects on human health. However, bioavailability and, particular, intestinal absorption mechanism not yet been clearly identified. The aim of our work was to quantify characterize vitro the nature transport two flavonoids distinguished by physicochemical pharmacological properties: quercetin, a flavan-3-ol, naringenin, flavanone....
The theory of superconductor-ferromagnet heterostructures with two ferromagnetic layers predicts the generation a long-range, odd-in-frequency triplet pairing at noncollinear alignment (NCA) magnetizations F layers. This has been detected in Nb/Cu${}_{41}$Ni${}_{59}$/normal conducting- (nc-) Nb/Co/CoO${}_{x}$ spin-valve-type proximity effect heterostructure, which very thin Nb film between serves as spacer nc metal. resistance sample function an external magnetic field shows that for not too...
BRAFV600E mutation is associated with a poor outcome in metastatic colorectal cancer (mCRC). This clinical trial investigated the efficacy of triplet chemotherapy (fluorouracil, folinic acid, oxaliplatin, and irinotecan) combined either cetuximab or bevacizumab patients previously untreated BRAFV600E-mutant mCRC.In this controlled, randomized, open-label phase II trial, 109 were randomly assigned, 107 whom included into full analysis set (FAS). Patients assigned 2:1 ratio to receive...
We report on the first observation of a pronounced reentrant superconductivity phenomenon in superconductor/ferromagnet layered system. The results were obtained using superconductor/ferromagnetic-alloy bilayer $\mathrm{Nb}/{\mathrm{Cu}}_{1\ensuremath{-}x}{\mathrm{Ni}}_{x}$. superconducting transition temperature ${T}_{c}$ drops sharply with increasing thickness ${d}_{\mathrm{CuNi}}$ ferromagnetic layer, until complete suppression is observed at...
Anti-Müllerian hormone (AMH) is an established biomarker for assessing ovarian reserve and predicting response to controlled stimulation. Its routine clinical use hampered by the variability low-throughput of available enzyme-linked immunosorbent assays (ELISA). The presented study examined if a fully automated AMH electrochemiluminescence assay (ECLIA; Elecsys® assay, Roche Diagnostics) was suitable measuring levels in healthy women those diagnosed with polycystic ovary syndrome (PCOS)....
Background The 1α,25-dihydroxy-3-epi-vitamin-D3 (1α,25(OH)2-3-epi-D3), a natural metabolite of the seco-steroid vitamin D3, exerts its biological activity through binding to cognate D nuclear receptor (VDR), ligand dependent transcription regulator. In vivo action 1α,25(OH)2-3-epi-D3 is tissue-specific and exhibits lowest calcemic effect compared that induced by 1α,25(OH)2D3. To further unveil structural mechanism structure-activity relationships complex, we characterized some in vitro...
Background Repeated inhalation of allergen at low‐dose induces an increase in bronchial hyper‐responsiveness, without any associated symptom. The concomitant events the bronchus have not been described. Objective We studied dynamic number mast cells airways patients with mild asthma before and after repeated expression nerve growth factor (NGF), which is reported to promote survival cells. Methods Twelve cat were enrolled random a blind placebo‐controlled study, submitted exposure (1/5...
Abstract CD25+ T regulatory (Treg) cells play a central role regarding the maintenance of peripheral tolerance via suppression autoaggressive CD4+ cells, CD8+ and Th1 cells. In this study we demonstrate that Treg can also suppress differentiation murine conventional toward Th2 in contact-dependent manner. However, cytokine production proliferation established could not be inhibited by freshly isolated whereas strong inhibition differentiated vitro preactivated observed. Inhibition both is...
We studied the involvement of lectin-like receptors in phagocytosis unopsonized heat-killed yeast (Saccharomyces cerevisiae) by murine macrophage-like cell lines and peritoneal resident macrophages. For this purpose we used a technique that allowed us to discriminate ingested adsorbed yeast. The internalization can be partly inhibited soluble polyosides such as laminarin (beta-glucan) or alpha-mannan. However, when they were together (0.4 mg/ml alpha-mannan 0.4 laminarin), almost complete...