A5030045844- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Synthetic Organic Chemistry Methods
- Bioactive Compounds and Antitumor Agents
- Multicomponent Synthesis of Heterocycles
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Synthesis and Biological Evaluation
- Metal complexes synthesis and properties
- Marine Sponges and Natural Products
- Click Chemistry and Applications
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Cholinesterase and Neurodegenerative Diseases
- Ferrocene Chemistry and Applications
- Enzyme function and inhibition
- Fungal Biology and Applications
- Organoselenium and organotellurium chemistry
- Sesquiterpenes and Asteraceae Studies
- Biological Activity of Diterpenoids and Biflavonoids
Universidad de La Laguna
2016-2025
Pfizer (United Kingdom)
2021
Laguna Research
2015-2020
Hospital Universitario Dr José Eleuterio Gonzalez
2015-2020
Institute of Organic Chemistry
2015-2018
Sardar Patel University
2015-2018
Observatorio de la Inmigración de Tenerife
2017
Universidad Autónoma de Madrid
2015
Instituto de Productos Naturales y Agrobiología
2014
Libertador Experimental Pedagogical University
2012
Quinoxaline is a fused heterocycle ring template present in diverse pharmacophore and widely used medicinal chemistry. Owing to its vast pharmaceutical profile, several quinoxalines analogous displayed their distinct pharmacological activities. In the last couple of years, researchers have established via green protocol, multi-component cascades, one-pot synthesis, combinatorial pin-point approach using effective catalysts reagents. It being further researched develop novel entities for...
There is a continuous and pressing need to establish new brain-penetrant bioactive compounds with anti-cancer properties. To this end, series of 4'-((4-substituted-4,5-dihydro-1H-1,2,3-triazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile (OTBN-1,2,3-triazole) derivatives were synthesized by click chemistry. The designed from diverse alkynes N
Twenty-three new derivatives of ( R / S )-TDHPM-5-carboxanilide have been synthesized with up to 99% yield. All racemates were separated using chiral HPLC (Prep LC) which provided 99.99% purity. AC was determined circular dichroism spectra.
In this communication, we present the synthesis of new platinum complexes based on hydroxyquinoline ligands. We demonstrate importance and role halogen substitution as well chelation, which are essential structural characteristics for finding good cytotoxicities.
The potential of structurally new ferrocene-functionalized guanidines as redox-active precursors for the synthesis heterometallic platinum(II)–guanidine complexes with anticancer activity was studied. To this end, an atom-economical catalytic approach followed by using ZnEt2 to catalyze addition aminoferrocene and 4-ferrocenylaniline N,N′-diisopropylcarbodiimide. Furthermore, reaction a platinum(II) source newly obtained Fc–N═C(NHiPr)2 (3) Fc(1,4-C6H4)–N═C(NHiPr)2 (4) provided access...
Starting from natural steroids (diosgenin, hecogenin, smilagenin, estrone), we have prepared a wide panel of selenoderivatives, including benzoselenazolones, selenosemicarbazones, isoselenocyanates, selenoureas, selenocyanates and diselenides, with the aim developing new families potential chemotherapeutic agents. The modification organoselenium moieties, their position on steroid provided valuable information concerning antiproliferative activities. Among all accessed herein, best profile...
Substrate selectivity in the novel multi-component reaction of 5-aminoindazole, barbituric acid derivatives and aldehyde is explored.
In this study, we demonstrate a simple, highly efficient, rapid and convenient series of 2,4-dimethoxy-tetrahydropyrimido[4,5-b]quinolin-6(7H)-ones 4a-v. Microwave irradiation facilitates the one-pot multicomponent reaction different aromatic aldehydes, 6-amino-2,4-dimethoxypyrimidine dimedone using glacial acetic acid. Metal-free synthesis, shorter time, higher product yield, easy purification without column chromatography outstanding green credential parameters are key features protocol....
Isatin derivatives have attracted a lot of interest for their potential in the development new anticancer drugs. A library 38 isatin derivatives, created through an Ugi four-component reaction, underwent initial screening panel six human solid tumor cell lines. The four most active were then selected further testing. These compounds showed selectivity towards non-small lung cancer (NSCLC) line SW1573, whilst NSCLC A549 cells barely affected. combination phenotypic assays, including wound...
Considering early-stage drug discovery programs, the Ugi four-component reaction is a valuable, flexible, and pivotal tool, facilitating creation of two new amide bonds in one-pot fashion to effectively yield desired α-aminoacylamides. Here, we highlight reputation this approach access number scaffold diversity library isatin-based α-acetamide carboxamide oxindole hybrids, promising anticancer agents, mild fast sustainable process. The was tested against six human solid tumor cell lines,...
Abstract A series of functionalized tetrahydropyran and dihydropyran derivatives was synthesized by means a Prins‐type cyclization between unsaturated alcohols several aldehydes. An unprecedented dimer bearing two 4‐chloro‐5,6‐dihydro‐2 H ‐pyran scaffolds obtained in high yield. panel three representative human solid tumor cells from diverse origin used to assess the cytotoxicity compounds. Overall, results show relevance chlorovinyl group biological activity, 2‐alkyl‐4‐chloro‐5,6‐dihydro‐2...
Abstract In this study, we explored the catalyst‐free one‐pot multi‐component synthesis of 1,4‐dihydropyridine derivatives by following green chemistry protocol. The present approach shows significant outcomes such as yield up to 94%, reaction, easy workup procedure and shorter period reaction time. work also highlighted comparison yields obtained under both neat solvent media well. anti‐proliferative activity all newly synthesized compounds has been assessed against six human solid tumor...
The novel approach in the treatment of complex multifactorial diseases, such as neurodegenerative disorders and cancer, requires a development efficient multi-targeting oriented drugs. Since oxidative stress significantly contributes to pathogenesis cancer disorders, potential drug candidates should possess good antioxidant properties. Due promising biological activities shown for structurally related (1,3-thiazol-2-yl)hydrazones, focused library 12 benzylidene-based...
In this study, we report on antiproliferative benzyloxy dihydropyrimidinones (DHPMs) produced by the Biginelli reaction of benzaldehyde, urea, and diverse 1,3-diones. The was catalyzed lanthanum triflate completed within 1-1.5 h, with 74-97% yield. assay carried out for all synthesized against six human solid tumor cell lines. Six compounds showed good activity GI50 values below 5 μM. Among compounds, most potent derivative lines in range 1.1-3.1 These DHPMs comply druglikeness. Furthermore,...
The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound very useful tool in design drugs with optimized pharmacological properties. In field carbohydrates, selective installation at C2 position has proven particularly interesting, some 2-deoxy-2-fluorosugar derivatives being currently market. We have now transferred this feature immunoregulatory glycolipid mimetics that contain sp2-iminosugar moiety, namely sp2-iminoglycolipids...
Being aware of the need to develop more efficient therapies against cancer, herein we disclose an innovative approach for design selective antiproliferative agents. We have accomplished conjugation a coumarin fragment with lipophilic cations (triphenylphosphonium salts, guanidinium) providing mitochondriotropic agents that simultaneously target also carbonic anhydrases IX and XII, involved in development progression cancer. The new compounds prepared turned out be strong inhibitors XII human...