A5083844530- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Glycosylation and Glycoproteins Research
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Carbohydrate Chemistry and Synthesis
- Diabetes and associated disorders
- CNS Lymphoma Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Neurological Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- Fluorine in Organic Chemistry
- Anesthesia and Neurotoxicity Research
- Animal Ecology and Behavior Studies
- Endoplasmic Reticulum Stress and Disease
Biomedical Research and Innovation Institute of Cadiz
2021-2025
Hospital Universitario Puerta del Mar
2022-2024
The unique electronic properties of the fluorine atom make its strategic incorporation into a bioactive compound very useful tool in design drugs with optimized pharmacological properties. In field carbohydrates, selective installation at C2 position has proven particularly interesting, some 2-deoxy-2-fluorosugar derivatives being currently market. We have now transferred this feature immunoregulatory glycolipid mimetics that contain sp2-iminosugar moiety, namely sp2-iminoglycolipids...
Abstract Huntington’s disease (HD) is caused by an aberrant expansion of CAG repeats in the HTT gene that mainly affects basal ganglia. Although striatal dysfunction has been widely studied HD mouse models, other brain areas can also be relevant to pathology. In this sense, we have special interest on retina as most exposed part central nervous system enable health monitoring patients using noninvasive techniques. To establish appropriate tissue for studies, need correlate retinal...
Diabetic retinopathy (DR) is one of the most prevalent secondary complications associated with diabetes. Specifically, Type 1 Diabetes Mellitus (T1D) has an immune component that may determine evolution DR by compromising response retina, which mediated microglia. In early stages DR, permeabilization blood-retinal barrier allows cells from peripheral system to interact retinal system. The use new bioactive molecules, such as 3-(2,4-dihydroxyphenyl)phthalide (M9), powerful anti-inflammatory...
The unique electronic properties of the fluorine atom makes its strategic incorporation into a bioactive compound very useful tool in design drugs with optimized pharmacological properties. In field carbohydrates, selective installation at C2 position has proven particularly interesting, some 2-deoxy-2-fluorosugar derivatives being currently market. We have now transferred this feature immunoregulatory glycolipid mimetics that contain sp2-iminosugar moiety, namely sp2-iminoglycolipids...
Abstract Huntington’s disease (HD) is a devastating disorder caused by aberrant expansion of CAG repeats in the HTT gene. Striatal dysfunction has been widely studied HD mouse models. However, cumulative evidence indicates that retina can also be functionally altered with consequences for visual function and circadian rhythms. The most exposed part central nervous system used monitoring health status patients using noninvasive techniques. To establish as an appropriate tissue studies, we...
<h3>Background</h3> In Huntington's disease (HD), striatal dysfunction has been intensively studied in mouse models as basal ganglia are the main brain areas affected patients, and explains most evident symptomatology. Nonetheless, cumulative evidences indicate that retina can also be functionally altered with consequences for visual function circadian rhythms. addition, is exposed part of central nervous system used non-invasive monitoring patients' health. <h3>Aims</h3> To firmly establish...
<h3>Background</h3> There is increasing evidence that structural and functional integrity of visual pathways are compromised in Huntington's disease (HD) mouse models patients. The retina can be an accessible window the CNS through non-invasive methods to monitor health status response potential treatments However, no correlation has been firmly established between molecular events occuring most affected brain area by polyQ expansion, striatum. <h3>Aims</h3> To explore as biomarkers source...