A5057409261- Synthesis and biological activity
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Cholinesterase and Neurodegenerative Diseases
- Phenothiazines and Benzothiazines Synthesis and Activities
- Multicomponent Synthesis of Heterocycles
- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Steroid Chemistry and Biochemistry
- Analytical Methods in Pharmaceuticals
- Chemical Synthesis and Analysis
- Synthesis and Reactions of Organic Compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Hormonal Regulation and Hypertension
- Chemical synthesis and alkaloids
- Chemical Synthesis and Reactions
- Neurotransmitter Receptor Influence on Behavior
- RNA Interference and Gene Delivery
- Cannabis and Cannabinoid Research
- Cancer therapeutics and mechanisms
- Crystallization and Solubility Studies
- Blood Coagulation and Thrombosis Mechanisms
- Organometallic Compounds Synthesis and Characterization
Parul University
2020-2024
Guru Jambheshwar University of Science and Technology
2018-2024
Maharaja Sayajirao University of Baroda
2013-2023
Salam University
2019
GTx (United States)
2018
Indian Institute of Information Technology Vadodara
2015-2016
Weatherford College
2012
Sinhgad Dental College and Hospital
2008
Periyar University
2005
Banaras Hindu University
2001
Decaprenylphosphoryl-β-d-ribose 2'-epimerase (DprE1), a vital enzyme for cell wall synthesis, plays crucial role in the formation of lipoarabinomannan and arabinogalactan. It was first reported as druggable target on basis inhibitors discovered high throughput screening drug library. Since then, with different types chemical scaffolds have been their activity against this enzyme. Formation covalent or noncovalent bond by interacting ligand causes loss its catalytic which ultimately leads to...
A novel series of hybrid molecules were designed and synthesized by fusing the pharmacophoric features cholinesterase inhibitor donepezil diarylthiazole as potential multitarget-directed ligands for treatment Alzheimer’s disease (AD). The compounds showed significant in vitro anticholinesterase (anti-ChE) activity, most potent compound (44) among them showing highest activity (IC50 value 0.30 ± 0.01 μM) AChE (1.84 0.03 BuChE. Compound 44 mixed inhibition enzyme kinetic studies. Some...
Mononuclear transition metal(II) complexes of the type M(L) 2 ⋅2H O (where M = Co, Ni, Cu, Zn) have been synthesized from uninegative Schiff base ligands (HL 1 –HL 4 ) designed by condensation 4‐fluorobenzylamine with 2‐hydroxy‐1‐naphthaldehyde/3,5‐dichlorosalicylaldehyde/3,5‐dibromosalicylaldehyde/3‐bromo‐5‐chlorosalicylaldehyde. The compounds were successfully characterized using spectroscopic and physiochemical methods together elemental analysis. Spectroscopic elucidation indicates a...
A series of twenty compounds inclusive bidentate Schiff bases derived from condensation 4‐methyl‐3‐thiosemicarbazide with substituted derivatives napthaldehyde/benzaldehyde/salicylaldehyde and their mononuclear Co (II), Ni Cu (II) Zn complexes in molar ratio (1:1) were synthesized characterized. The coordination behavior, modes bonding overall geometry the was known elemental analysis, spectral techniques (IR, UV–Vis, 1 H NMR, 13 C ESR ESI‐mass), magnetic moment measurements, conductance,...
The multifaceted nature of Alzheimer's disease (AD) demands treatment with multitarget-directed ligands (MTDLs) to confront the key pathological aberrations. A novel series triazinoindole derivatives were designed and synthesized. In vitro studies revealed that all compounds showed moderate good anticholinesterase activity; most active compound 23e an IC50 value 0.56 ± 0.02 μM for AChE 1.17 0.09 BuChE. These are also endowed potent antioxidant activity. To understand plausible binding mode...
The temporal gaps in the GRACE and GRACE-FO satellite missions present significant challenges for analyzing Terrestrial Water Storage (TWS) anomalies. This study employs Convolutional-Long Short-Term Memory (CNN-LSTM) neural networks to bridge these gaps, enabling effective drought characterization major Indian river basins. approach integrates GRACE-TWS data with meteorological climatic factors such as precipitation, temperature, runoff, evapotranspiration, vegetation generate reconstructed...