A5089328202- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Genetic Neurodegenerative Diseases
- Pluripotent Stem Cells Research
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Pesticide Exposure and Toxicity
- Skin Protection and Aging
- Coenzyme Q10 studies and effects
- Neuroscience and Neuropharmacology Research
- Effects and risks of endocrine disrupting chemicals
- Cholinesterase and Neurodegenerative Diseases
- Curcumin's Biomedical Applications
- Genomics, phytochemicals, and oxidative stress
- Conducting polymers and applications
- Wnt/β-catenin signaling in development and cancer
- Ginkgo biloba and Cashew Applications
- Drug-Induced Hepatotoxicity and Protection
- Anesthesia and Neurotoxicity Research
- Neurological disorders and treatments
- Immunotoxicology and immune responses
- Heavy Metal Exposure and Toxicity
Indian Institute of Toxicology Research
2015-2025
Academy of Scientific and Innovative Research
2015-2025
Bennett University
2024-2025
Chinese Academy of Sciences
2024
Cornell University
2007-2023
Presbyterian Hospital
2007-2023
Council of Scientific and Industrial Research
2011-2019
Adler
2017
Dabur (India)
2015
Sappasithiprasong Hospital
2015
Neurogenesis, a process of generation new neurons, is reported to be reduced in several neurodegenerative disorders including Alzheimer's disease (AD). Induction neurogenesis by targeting endogenous neural stem cells (NSC) could promising therapeutic approach such diseases influencing the brain self-regenerative capacity. Curcumin, neuroprotective agent, has poor bioavailability. Herein, we report that curcumin-encapsulated PLGA nanoparticles (Cur-PLGA-NPs) potently induce NSC proliferation...
Sustained and safe delivery of dopamine across the blood brain barrier (BBB) is a major hurdle for successful therapy in Parkinson's disease (PD), neurodegenerative disorder. Therefore, present study we designed neurotransmitter dopamine-loaded PLGA nanoparticles (DA NPs) to deliver brain. These slowly constantly released dopamine, showed reduced clearance plasma, quinone adduct formation, decreased autoxidation. DA NPs were internalized dopaminergic SH-SY5Y cells neurons substantia nigra...
Abstract In general, edge computing networks are based on a distributed environment and hence, present some difficulties to obtain an appropriate load balancing, especially under dynamic workload limited resources. The conventional approaches of Load balancing like Round-Robin Threshold-based fails in scalability flexibility issues when applied highly variable environments. To solve the problem how achieve steady-state balance provide adaption networks, this paper proposes new framework that...
We investigated the role of PPAR γ coactivator 1α (PGC-1α) in muscle dysfunction Huntington's disease (HD). observed reduced PGC-1α and target genes expression HD transgenic mice. produced chronic energy deprivation mice by administering catabolic stressor β-guanidinopropionic acid (GPA), a creatine analogue that reduces ATP levels, activates AMP-activated protein kinase (AMPK), which turn PGC-1α. Treatment with GPA resulted increased AMPK, genes, for oxidative phosphorylation, electron...
The NF-E2-related factor-2 (Nrf2)/antioxidant response element (ARE) signaling pathway regulates phase 2 detoxification genes, including a variety of antioxidative enzymes. We tested neuroprotective effects the synthetic triterpenoid CDDO-MA, potent activator Nrf2/ARE signaling. CDDO-MA treatment neuroblastoma SH-SY5Y cells resulted in Nrf2 upregulation and translocation from cytosol to nucleus subsequent activation ARE genes. blocked t-butylhydroperoxide-induced production reactive oxygen...
Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via transcriptional dysregulation of number genes, including those involved mitochondrial biogenesis. Here we show that transglutaminase 2, which is upregulated HD, exacerbates acting as selective corepressor nuclear genes; 2 interacts directly with histone H3 nucleus. In cellular model inhibition de-repressed two established regulators function, PGC-1alpha and cytochrome c...
We investigated the ability of AMP-activated protein kinase (AMPK) to activate PPARγ coactivator-1α (PGC-1α) in brain, liver and brown adipose tissue (BAT) NLS-N171-82Q transgenic mouse model Huntington's disease (HD). In striatum HD mice, baseline levels PGC-1α, NRF1, NRF2, Tfam, COX-II, PPARdelta, CREB ERRα mRNA mitochondrial DNA (mtDNA), were significantly reduced. Administration creatine analog beta guanidinopropionic acid (GPA) reduced ATP PCr increased AMPK both cerebral cortex...
The regulatory dynamics of mitochondria comprises well orchestrated distribution and mitochondrial turnover to maintain the circuitry homeostasis inside cells. Several pieces evidence suggested impaired its association with pathogenesis neurodegenerative disorders. We found that chronic exposure synthetic xenoestrogen bisphenol A (BPA), a component consumer plastic products, autophagy-mediated turnover, leading increased oxidative stress, fragmentation, apoptosis in hippocampal neural stem...
Abstract Ginkgo biloba extract (EGb), a potent antioxidant and monoamine oxidase B (MAO‐B) inhibitor, was evaluated for its anti‐parkinsonian effects in 6‐hydroxydopamine (6‐OHDA) rat model of the disease. Rats were treated with 50, 100, 150 mg/kg EGb 3 weeks. On day 21, 2 µL 6‐OHDA (10 µg 0.1% ascorbic acid saline) injected into right striatum, while sham‐operated group received vehicle. Three weeks after injection, rats tested rotational behaviour, locomotor activity, muscular...
Neurogenesis involves generation of new neurons through finely tuned multistep processes, such as neural stem cell (NSC) proliferation, migration, differentiation, and integration into existing neuronal circuitry in the dentate gyrus hippocampus subventricular zone. Adult hippocampal neurogenesis is involved cognitive functions altered various neurodegenerative disorders, including Alzheimer disease (AD). Ethosuximide (ETH), an anticonvulsant drug used for treatment epileptic seizures....
Neurogenesis is a process of generation new neurons in the hippocampus and associated with learning memory. Carbofuran, carbamate pesticide, elicits several neurochemical, neurophysiological, neurobehavioral deficits. We evaluated whether chronic prenatal oral exposure carbofuran during gestational days 7–21 alters postnatal hippocampal neurogenesis at day 21. found treatment significantly decreased bromodeoxyuridine (BrdU) positive cell proliferation long-term survival only but not...