A5100374370- Computational Drug Discovery Methods
- Biochemical and Structural Characterization
- Genetic Neurodegenerative Diseases
- Biological Stains and Phytochemicals
- Hereditary Neurological Disorders
- Skin and Cellular Biology Research
- Context-Aware Activity Recognition Systems
- Ion channel regulation and function
- Molecular Biology Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Spatial and Panel Data Analysis
- Indoor and Outdoor Localization Technologies
- Microbial Metabolism and Applications
- Energy Efficient Wireless Sensor Networks
- thermodynamics and calorimetric analyses
- Data-Driven Disease Surveillance
- Plant-based Medicinal Research
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Gout, Hyperuricemia, Uric Acid
- Biological Activity of Diterpenoids and Biflavonoids
- Immunotherapy and Immune Responses
- Alcohol Consumption and Health Effects
- Scientific Computing and Data Management
Zhejiang University of Technology
2025
University of North Carolina at Chapel Hill
2022
Peking University
2002-2021
State Key Laboratory of Genetic Engineering
2015
Fudan University
2015
Cornell University
2009-2010
State Key Laboratory for Structural Chemistry of Unstable and Stable Species
2004-2009
National Medical Products Administration
2008
Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via transcriptional dysregulation of number genes, including those involved mitochondrial biogenesis. Here we show that transglutaminase 2, which is upregulated HD, exacerbates acting as selective corepressor nuclear genes; 2 interacts directly with histone H3 nucleus. In cellular model inhibition de-repressed two established regulators function, PGC-1alpha and cytochrome c...
Huntington's disease (HD) represents an important model for neurodegenerative disorders and proteinopathies. It is mainly caused by cytotoxicity of the mutant huntingtin protein (Htt) with expanded polyQ stretch. While Htt ubiquitously expressed, HD characterized selective neurodegeneration striatum. Here we report a striatal-enriched orphan G protein-coupled receptor(GPCR) Gpr52 as stabilizer in vitro vivo. modulates via cAMP-dependent but PKA independent mechanisms. located within intron...
Epidermal growth factor (EGF) exerts pleiotropic effects during oncogenesis, including the stimulation of cell migration and invasiveness. Although a number traditional signaling proteins (e.g. Ras Rho GTPases) have been implicated in EGF-stimulated cancer migration, less is known about identity those functioning further downstream this pathway. Here we used HeLa carcinoma cells as model system for investigating role tissue transglutaminase (TGase), protein that has linked to invasion....
The SARS coronavirus 3C-like proteinase is considered as a potential drug design target for the treatment of severe acute respiratory syndrome (SARS). Owing to lack available drugs SARS, discovery inhibitors that can potentially be optimized appears highly desirable. We have built "flexible" three-dimensional model by homology modeling and multicanonical molecular dynamics method used virtual screening chemical databases. After Dock procedures, strategies including pharmocophore model,...
Abstract A practically useful method for the formation of highly oxygenated bicyclo[3.2.1]octane ring system through Mn(OAc) 3 ‐mediated radical cyclization alkynyl ketones was developed, which opens up a new avenue total synthesis number oxidized diterpenoids. Application this enabled first (−)‐glaucocalyxin A. Other salient features include enantioselective conjugate addition/acylation cascade reaction, Yamamoto aldol and an intramolecular Diels–Alder reaction to assemble A/B system.
The function-based protein classification holds tremendous promise for molecular recognition and the structure-based design process. We describe here a new strategy combined with multiple-docking tools "affinity fingerprint" analysis technology to detect functional relationships among proteins based on substrate binding features protein−ligand interaction matrix apply it successfully family of phospholipase A2 investigate binding, classification, inhibitor selection, evaluation. Binding data...
With the explosive growth and wide spread of smartphones with Wi-Fi enabled, people are used to accessing internet through network interfaces smartphones. In meanwhile, periodically transmit messages, even when not connect a network. this paper, we describes Mo-Fi system which monitors aggregates message transmissions in area interest using non-intrusive sniffers. proposes an optimized channel detection selection method switch best channels automatically aggregate messages based on data...
In this paper, we propose a Spatial Robust Mixture Regression model to investigate the relationship between response variable and set of explanatory variables over spatial domain, assuming that relationships may exhibit complex spatially dynamic patterns cannot be captured by constant regression coefficients. Our method integrates robust finite mixture Gaussian with constraints, simultaneously handle non-stationarity, local homogeneity, outlier contaminations. Compared existing models, our...
ADVERTISEMENT RETURN TO ISSUEPREVErratumORIGINAL ARTICLEThis notice is a correctionCorrection to Identification of Small-Molecule Inhibitors against Human Leukocyte Antigen-Death Receptor 4 (HLA-DR4) Through Comprehensive StrategyZhenming Liu*, Bo Li, Xia Li*, Liangren Zhang, and Luhua LaiCite this: J. Chem. Inf. Model. 2011, 51, 7, 1737Publication Date (Web):June 16, 2011Publication History Received31 May 2011Published online16 June inissue 25 July...
Objective To study the anti-depressant effect of Xiaoyaofang on mice with behavioral despair. Method The were given forced swimming test and tail suspension to observe Xiaoyaofang. Result high dosage Xi-aoyaofang significantly shortened fast time in mice(P < 0.05). And showed trend shortening needed test. Conclusion have an despair. Key words: Xiaoyao powders/PD; Decoctions; Depression/DT