A5026900397- Synthesis and biological activity
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Medicinal Plants and Neuroprotection
- Air Quality and Health Impacts
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and Carotid Artery Diseases
- Tryptophan and brain disorders
- Cerebrospinal fluid and hydrocephalus
- Autoimmune Neurological Disorders and Treatments
- Heavy Metal Exposure and Toxicity
- Parkinson's Disease Mechanisms and Treatments
- Air Quality Monitoring and Forecasting
- Indoor Air Quality and Microbial Exposure
- Synthesis and Biological Evaluation
- Renin-Angiotensin System Studies
- Neurological Disease Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Nicotinic Acetylcholine Receptors Study
- Neuroscience of respiration and sleep
- Natural product bioactivities and synthesis
University of Cincinnati
2004-2021
Central Drug Research Institute
2011-2021
Academy of Scientific and Innovative Research
2014-2021
Institute of Medical Sciences
1990-2020
All India Institute of Medical Sciences
2011-2019
Max Healthcare
2019
King George's Medical University
2007-2017
Council of Scientific and Industrial Research
2016-2017
Creative Commons
2016
Rani Durgavati University
2016
Background and Purpose —The Greater Cincinnati/Northern Kentucky Stroke Study was designed to be the first large, population-based metropolitan study of temporal trends in stroke incidence rates outcome within a biracial population. Methods —We are identifying all hospitalized autopsied cases transient ischemic attack (TIA) among 1.3 million inhabitants five-county region for period 7/1/93–6/30/94. We have already prospectively monitored out-of-hospital TIAs this same time at 128 screening...
Background and Purpose— Transient ischemic attacks (TIAs) have been shown to be a strong predictor of subsequent stroke death. We present the incidence short-term prognosis TIA within large population with significant proportion minorities out-of-hospital TIA. Methods— cases were identified between July 1, 1993 June 30, 1994 from Greater Cincinnati/Northern Kentucky 1.3 million inhabitants by previously published surveillance methods, including inpatient events. Incidence rates adjusted 1990...
Background and Purpose — Intracerebral hemorrhage (ICH) has a 30-day mortality rate of 40% to 50% lacks proven treatment. We report preplanned, midpoint analysis the first population-based, case-control study that examines both genetic environmental risk factors ICH. Methods prospectively identified cases hemorrhagic stroke at all 16 hospitals in Greater Cincinnati/Northern Kentucky region. All underwent medical record neuroimaging review. Cases enrolled direct interview sampling arm were...
Background and Purpose— Excess mortality resulting from stroke is an important reason why blacks have higher age-adjusted rates than whites. This observation has 2 possible explanations: Strokes occur more commonly among or after stroke. Our population-based epidemiological study set in the Greater Cincinnati/Northern Kentucky region of 1.31 million people, which representative US white black populations with regard to many demographic socioeconomic characteristics. Methods— Hospitalized...
Sustained and safe delivery of dopamine across the blood brain barrier (BBB) is a major hurdle for successful therapy in Parkinson's disease (PD), neurodegenerative disorder. Therefore, present study we designed neurotransmitter dopamine-loaded PLGA nanoparticles (DA NPs) to deliver brain. These slowly constantly released dopamine, showed reduced clearance plasma, quinone adduct formation, decreased autoxidation. DA NPs were internalized dopaminergic SH-SY5Y cells neurons substantia nigra...
OBJECTIVE— Diabetes is a well known risk factor for stroke, but the impact of diabetes on stroke incidence rates not known. This study uses population-based to describe epidemiology ischemic in diabetic patients. RESEARCH DESIGN AND METHODS— Hospitalized cases were ascertained by ICD-9 discharge codes, prospective screening emergency department admission logs, and review coroner’s cases. A sampling scheme was used ascertain out-of-hospital setting. All potential underwent detailed chart...
Background and Purpose— Acute ischemic stroke patients are infrequently treated with recombinant tissue plasminogen activator (rtPA). We present unique population-based data regarding the eligibility of for rtPA treatment. Methods— All strokes presenting to an emergency department (ED) within a biracial population 1.3 million were identified. The patient was considered eligible on basis exclusion criteria from National Institute Neurological Disorders Stroke trial. Results— Of 2308 strokes,...
This study was designed to determine the incidence of thoracic bone infarction in patients with sickle cell diseases who were hospitalized acute chest or back pain above diaphragm and test hypothesis that incentive spirometry can decrease atelectasis pulmonary infiltrates.
Background and Purpose— Blacks have an excess burden of stroke compared with whites; however, data comparing ischemic subtypes among the 2 groups are limited typically involve relative frequencies. The objective this study is to compare incidence rates between blacks whites within a large, representative, biracial population. Methods— Greater Cincinnati/Northern Kentucky Stroke Study designed measure trends all strokes well-defined, Hospitalized cases were ascertained by International...
Background and Purpose — Subarachnoid hemorrhage (SAH) caused by ruptured intracranial aneurysm affects approximately 16 000 Americans annually, almost 40% of affected patients die within 30 days despite the best current therapy. Prevention SAH is therefore paramount importance. We present a preliminary analysis risk factors for from our population-based, case-control study. Methods Cases were prospectively collected matched 2:1 age, race, gender to controls using random digit dialing....
Background and Purpose— Many advances were made in stroke prevention strategies during the 1990s, yet temporal trends incidence case-fatality have not been reported United States. Blacks a 2-fold higher risk of stroke; however, there are no data over time showing if any progress has reducing racial disparity incidence. The objective this study was to examine within large, biracial population 1990s. Methods— Within 1.3 million, all strokes ascertained at local hospitals using International...
Airborne dust and microorganisms are associated with respiratory diseases increased mortality morbidity. Farmers at high risk of exposure to both these hazards. Very limited information, however, is available on the combined exposures hazards different types farms. Moreover, most previous studies have measured mass concentration particles ignoring particle size. In this study, farmers' airborne was studied using our newly developed personal sampling system. Particle number size distribution...
Abstract The antistress effect of bacosides Brahmi ( Bacopa monnieri , BBM), dissolved in distilled water, was studied adult male Sprague Dawley rats by administering oral doses 20 and 40 mg/kg for 7 consecutive days. In half the animals treated with or BBM, stress given 2 h after last dose. Stress also administered to water alone. at both doses, did not induce a significant change expression Hsp70 any brain region studied while alone produced increase all regions. A decrease activity...
Background and Purpose —The volume of ischemic stroke on CT scans has been studied in a standardized fashion acute therapy trials with median volumes between 10.5 to 55 cm 3 . The first-ever the population is not known. Methods first phase population-based Greater Cincinnati/Northern Kentucky Stroke Study identified all strokes occurring blacks greater Cincinnati region January June 1993. patients this study who had clinical were identified, was measured. Results —There 257 verified cases...