A5068843627- Neuroscience and Neuropharmacology Research
- Protein Tyrosine Phosphatases
- Tryptophan and brain disorders
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Medicinal Plants and Neuroprotection
- Ion channel regulation and function
- Neuroendocrine regulation and behavior
- Chemical synthesis and alkaloids
- Pharmacological Effects of Natural Compounds
- Memory and Neural Mechanisms
- Lysosomal Storage Disorders Research
- Neurotransmitter Receptor Influence on Behavior
- Endoplasmic Reticulum Stress and Disease
- Autism Spectrum Disorder Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Treatment of Major Depression
- Histone Deacetylase Inhibitors Research
- Nuclear Receptors and Signaling
- Biochemical Acid Research Studies
- Natural Compound Pharmacology Studies
- Biological and pharmacological studies of plants
- Phytoestrogen effects and research
- Biochemical Analysis and Sensing Techniques
Yale University
2013-2023
Lupin Pharmaceuticals (India)
2019
Central Drug Research Institute
2010-2015
Xiamen University
2014
This study identifies an unusual sulfur-based chemical as a novel and specific inhibitor of the tyrosine phosphatase STEP shows that it can improve cognitive function mouse model Alzheimer's disease.
Previous studies have shown that the administration of NMDA antagonist can induce negative symptoms schizophrenia which be tested through enhanced immobility observed in forced swim test (FST). In present study, we compared effects acute as well chronic a noncompetitive receptor antagonist, ketamine on FST, and another behaviour despair model, tail suspension (TST). Our observations suggest induced state but such findings were not replicated TST model. Further, treatment with clozapine...
Context: Recent studies reveal the co-occurrence of both anxiety and depressive disorders in many clinical conditions, which has introduced concept mixed (MADD).Objective: The study evaluated ethanol leaf extract Ocimum sanctum (OS) Linn. (Labiatae), a prominent medicinal plant, against disorder, to evaluate its potency combating MADD.Materials methods: Swiss albino mice weighing 20–25 g were used. Gross behavior was observed through Digiscan animal activity monitor. Depression studied tail...
High levels of striatal-enriched protein tyrosine phosphatase (STEP) activity are observed in a number neuropsychiatric disorders such as Alzheimer's disease. Overexpression STEP results the dephosphorylation and inactivation many key neuronal signaling molecules, including ionotropic glutamate receptors. Moreover, genetically reducing AD mouse models significantly reversed cognitive deficits decreased receptor internalization. These support potential target for drug discovery treatment...
Context: Schizophrenia is a chronic disabling psychiatric disorder affecting 1% of the population worldwide. Due to adverse effects available antipsychotic medications, recent investigations have focused on search for well-tolerated, safe molecules from natural resources control severity and progression schizophrenia.Objective: To screen standardized extract Bacopa monniera Linn. (Scrophulariaceae) (BM) its potential in ketamine-induced psychosis model with mice.Materials methods: Graded...
The discovery of a series thiophenephenylsulfonamides as positive allosteric modulators (PAM) α7 nicotinic acetylcholine receptor (α7 nAChR) is described. Optimization this led to identification compound 28, novel PAM nAChR). Compound 28 showed good in vitro potency, with pharmacokinetic profile across species excellent brain penetration and residence time. robustly reversed the cognitive deficits episodic/working memory both time-delay scopolamine-induced amnesia paradigms object social...
Abstract The ability of monkeys and rats to carry out spatial working memory tasks has been shown depend on the persistent firing pyramidal cells in prefrontal cortex (PFC), arising from recurrent excitatory connections dendritic spines. These spines express hyperpolarization-activated cyclic nucleotide-gated (HCN) channels whose open state is increased by cAMP signaling, which markedly alter PFC network connectivity neuronal firing. In traditional neural circuits, activation these...
Abstract The ability of monkeys and rats to carry out spatial working memory tasks has been shown depend on the persistent firing pyramidal cells in prefrontal cortex (PFC), arising from recurrent excitatory connections dendritic spines. These spines express hyperpolarization-activated cyclic nucleotide-gated (HCN) channels whose open state is increased by cAMP signaling, which markedly alter PFC network connectivity neuronal firing. In traditional neural circuits, activation these...
Abstract Loss of dendritic spines and decline cognitive function are hallmarks patients with Alzheimer’s disease (AD). Previous studies have shown that AD pathophysiology involves increased expression a central nervous system-enriched protein tyrosine phosphatase called STEP (STriatal-Enriched Phosphatase). opposes the development synaptic strengthening by dephosphorylating substrates, including GluN2B, Pyk2 ERK1/2. Genetic reduction as well pharmacological inhibition improves hippocampal...