A5070484994- Click Chemistry and Applications
- Chemical Synthesis and Analysis
- Amyotrophic Lateral Sclerosis Research
- Carbohydrate Chemistry and Synthesis
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Dark Matter and Cosmic Phenomena
- Cosmology and Gravitation Theories
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Atomic and Subatomic Physics Research
- Cholinesterase and Neurodegenerative Diseases
- Advanced biosensing and bioanalysis techniques
- Chemical Synthesis and Reactions
- Parkinson's Disease Mechanisms and Treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Tryptophan and brain disorders
- Geophysics and Gravity Measurements
- Stellar, planetary, and galactic studies
- Pulsars and Gravitational Waves Research
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Tuberculosis Research and Epidemiology
Banaras Hindu University
2013-2025
James J. Peters VA Medical Center
2018-2025
Allen Institute for Brain Science
2022-2025
Icahn School of Medicine at Mount Sinai
2018-2025
Shanghai Institute for Science of Science
2025
National Institute of Malaria Research
2024
Mental Illness Research, Education and Clinical Centers
2020-2021
University of Allahabad
2021
University of Göttingen
2007-2018
Columbia University
2016-2017
Abstract A repeat expansion in the C9orf72 (C9) gene is most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we investigate single nucleus transcriptomics (snRNA-seq) epigenomics (snATAC-seq) postmortem motor frontal cortices from C9-ALS, C9-FTD, control donors. C9-ALS donors present pervasive alterations expression with concordant changes chromatin accessibility histone modifications. The greatest occur upper deep layer excitatory neurons,...
Abstract Multicomponent reactions are operationally simple and display a significant role in diverse chemical modification by reducing reaction times as well additional steps involved. In this review, we highlighted the impact of multi‐component assistance with modular Click chemistry to develop library triazole‐appended scaffolds including 1,2,3‐triazole‐fused heterocycles, glycoconjugates, macrocycles combinatorial synthesis differently functionalized triazoles along mechanistic insights...
Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in brain stem and spinal cord. Intracellular disruptions cytosolic mitochondrial calcium have been associated with MN degeneration, but underlying mechanisms are not well understood. The present evidence supports hypothesis that mitochondria target mutant SOD1-mediated toxicity familial amyotrophic (fALS) intracellular alterations might...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of defined motoneuron populations in brainstem and spinal cord. Although low cytosolic calcium ([Ca<sup>2+</sup>]<sub>i</sub>) buffering strong interaction between metabolic mechanisms [Ca<sup>2+</sup>]<sub>i</sub> have been associated with vulnerability, underlying cellular are barely understood. To elucidate molecular events, we used rapid charge-cooled device imaging to evaluate...
Previous studies have shown that the administration of NMDA antagonist can induce negative symptoms schizophrenia which be tested through enhanced immobility observed in forced swim test (FST). In present study, we compared effects acute as well chronic a noncompetitive receptor antagonist, ketamine on FST, and another behaviour despair model, tail suspension (TST). Our observations suggest induced state but such findings were not replicated TST model. Further, treatment with clozapine...
EDITORIAL article Front. Cell. Neurosci., 31 October 2013Sec. Cellular Neuropathology Volume 7 - 2013 | https://doi.org/10.3389/fncel.2013.00199
A novel organocatalyzed [3+2] cycloaddition reaction of nitroolefins with glycosyl azides as well organic has been developed for successful construction 1,5-disubstituted triazolyl glycoconjugates. This metal-free and acid-free, regioselective synthetic protocol proceeds in the presence only Schreiner thiourea organocatalysts, which enable required activation through double hydrogen bonding. The straightforward, operationally simple, regioselectivity this methodology, complementing to...
The present work describes a new and practical approach for the one-pot preparation of 4-aryl-NH-1,2,3-triazoles 4-glycosyl-NH-1,2,3-triazoles from multicomponent reaction involving aldehydes, nitroalkanes, sodium azide in presence 5 mol% silicomolybdic acid (SMA) as versatile biocompatible catalyst. One-pot sequential formation C-C C-N bonds, high yield, nature catalyst, easy handling, broad substrate scope 1,2,3-triazoles are notable advantages protocol.
Selective motoneurons (MNs) degeneration in the brain stem, hypoglossal (HMNs), and spinal cord resulting patients paralysis eventual death are prominent features of amyotrophic lateral sclerosis (ALS). Previous studies have suggested that mitochondrial respiratory impairment, low Ca2+ buffering homeostasis excitotoxicity pathological phenotypes found mice, cell culture models familial ALS (fALS) linked with Cu/Zn-superoxide dismutase 1 (SOD1) mutation. In our study, we aimed to understand...
Abstract: Over the last two decades, design and development of fluorescent chemosensors for targeted detection Heavy Transition-metal (HTM) ions, anions, biological ana-lytes, have drawn much interest. Since introduction click chemistry in 2001, triazole moie-ties become an increasingly prominent theme chemosensors. Triazoles generated via reactions are crucial sensing various ions analytes. Recently, number studies field pyrene appendant moieties has risen dramatically, with more...