A5101506601- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Immune responses and vaccinations
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Parasites and Host Interactions
- Tuberculosis Research and Epidemiology
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- Child Nutrition and Water Access
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- Toxin Mechanisms and Immunotoxins
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Chemical synthesis and pharmacological studies
- Airway Management and Intubation Techniques
- Global Maternal and Child Health
- Antioxidant Activity and Oxidative Stress
- Synthesis and Characterization of Heterocyclic Compounds
- Vaccine Coverage and Hesitancy
- MicroRNA in disease regulation
- Organometallic Compounds Synthesis and Characterization
- Paraoxonase enzyme and polymorphisms
- Enzyme function and inhibition
University of Georgia
2018-2025
Banaras Hindu University
2015-2024
University of Delhi
2024
Amity University
2024
Dr. Ram Manohar Lohia Institute of Medical Sciences
2021-2024
Tata Main Hospital
2024
National Institute of Pharmaceutical Education and Research
2024
Indian Institute of Technology BHU
2014-2022
King George's Medical University
2013-2022
Dr D Y Patil Dental College & Hospital
2021
Background. Recent reports indicated high miltefosine treatment failure rates for visceral leishmaniasis (VL) on the Indian subcontinent. To further explore pharmacological factors associated with these failures, a population pharmacokinetic-pharmacodynamic study was performed to examine relationship between drug exposure and in cohort of Nepalese patients VL. Methods. Miltefosine steady-state blood concentrations at end were analyzed using liquid chromatography tandem mass spectrometry. A...
Oxidative stress and neuroinflammation play a key role in dopaminergic (DA) neuronal degeneration, which results the hindrance of normal ongoing biological processes case Parkinson's disease. As shown several studies, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration, different behavioral parameters have suggested motor impairment damage antioxidant defence. Thus, some specific molecules found medicinal plants can be used to inhibit DA degeneration through their...
Parkinson's Disease (PD) is characterized by both motor and non-motor symptoms. The presynaptic neuronal protein, α-Synuclein, plays a pivotal role in PD pathogenesis associated with genetic sporadic origin of the disease. Ursolic Acid (UA) well-known bioactive compound found various medicinal plants, widely studied for its anti-inflammatory antioxidant activities.In this research article, neuroprotective potential UA has been further explored Rotenone-induced mouse model PD.To investigate...
Immunotherapies can treat many cancers, including difficult-to-treat cases such as lung cancer. Due to its tolerability, long-lasting therapeutic responses, and efficacy in a wide spectrum of patients, immunotherapy also help cancer, which has few treatment choices. Tumor-specific antigens (TSAs) for cancer vaccinations T-cell therapies are difficult discover. Neoantigens (NeoAgs) from genetic mutations, irregular RNA splicing, protein changes, or viral sequences tumor cells provide...
ABSTRACT Used with blood or serum, a new anti-K39 antibody immunochromatographic strip test (IT-Leish; DiaMed AG) proved sensitive (range, 99 to 100%) and specific 95 for the noninvasive serodiagnosis of visceral leishmaniasis in India. IT-Leish existing Kalazar Detect (InBios International, Inc.) yielded comparable results symptomatic infection identified apparent subclinical 15 32% healthy residents region where is highly endemic.
The outcome of Leishmania infection depends on parasite abilities to evade host immune response and its survival in hostile environment macrophages. Despite a wealth gained crucial information, strategies by which it dampens macrophage functions remain poorly understood. Micro RNAs (miRNAs) are evolutionarily conserved class endogenous 22-nucleotide small non-coding RNA gene products, described participate the regulation almost every cellular process investigated so far. In this study, we...
Protective variables for Coronavirus Disease 2019 (COVID-19) are unknown. "Trained immunity" of the populace as a result Bacille Calmette–Guérin (BCG) vaccination policy implementation and coverage had been suggested to be one factors responsible differential impact COVID-19 on different countries. Several trials underway evaluate potential protective role BCG in COVID-19. However, lack clarity use appropriate controls concerning measures "trained or heterologous cell-mediated immunity...
We evaluated the direct agglutination test (DAT), using freeze-dried (FD) and aqueous (AQ) antigen, rK39 immunochromatographic strip in diagnosis of Indian visceral leishmaniasis (VL). Sera from 508 subjects (150 parasitologically confirmed patients with VL, 100 153 healthy controls drawn non-endemic endemic regions, respectively, 105 other diseases presenting fever and/or splenomegaly) were tested. The sensitivity tests as follows: DAT (FD), 96% (95% CI 91-98); (AQ), 97% 93-99); test, 99%...
Background. India is the highest contributor to child anemia. About 89 million children in are anemic. The study determines factors that contributed anemia and examines role of existing programs reducing prevalence particularly EAG states. Methods. data from latest round National Family Health Survey (NFHS-3) used. Simple bivariate multinomial logistics regression analyses Results. 70% anemic all severe (6.7%) Rajasthan followed by Uttar Pradesh (3.6%) Madhya (3.4%). Children aged 12 17...
Micro RNAs (miRNAs) have emerged as a critical regulator of several biological processes in both animals and plants. They also been associated with regulation immune responses many human diseases during recent years. Visceral leishmaniasis (VL) is the most severe form leishmaniasis, which characterized by impairment innate adaptive responses. In present study, we observed that Leishmania establishes hypoxic environment host macrophages induces expression hypoxia inducible factor-1α (HIF-1α)...
Summary The diagnosis of visceral leishmaniasis (kala‐azar) remains difficult in rural endemic areas and practical reliable tests are badly needed. Two serological tests, the Direct Agglutination Test (DAT) an rK39‐antigen‐based dipstick test, were compared to parasitological a group 184 patients presenting at tertiary care centre south‐eastern Nepal with history fever ≥14 days splenomegaly; 139 had parasitologically proven kala‐azar 45 negative work‐up. rK39 showed sensitivity 97%...
The impact of zinc (Zn) sufficiency/supplementation on COVID-19-associated mortality and incidence (SARS-CoV-2 infections) remains unknown. During an infection, the levels free Zn are reduced as part "nutritional immunity" to limit growth replication pathogen ensuing inflammatory damage. Considering its key role in immune competency frequently recorded deficiency large sections different populations, has been prescribed for both prophylactic therapeutic purposes COVID-19 without any...