A5083330410- Nutrition and Health in Aging
- Growth Hormone and Insulin-like Growth Factors
- Nutritional Studies and Diet
- Diet and metabolism studies
- Neuropeptides and Animal Physiology
- Frailty in Older Adults
- Reproductive Physiology in Livestock
- Obesity, Physical Activity, Diet
- Dementia and Cognitive Impairment Research
- Receptor Mechanisms and Signaling
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Herpesvirus Infections and Treatments
- Chemical Synthesis and Analysis
- Neuroscience and Neuropharmacology Research
- Cardiovascular and exercise physiology
- Effects of Environmental Stressors on Livestock
- Body Composition Measurement Techniques
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Health Systems, Economic Evaluations, Quality of Life
- Animal Nutrition and Physiology
- Pancreatic function and diabetes
Centre Hospitalier de l’Université de Montréal
2016-2025
Université de Montréal
2016-2025
Quebec Network for Research on Aging
2020
Deleted Institution
2020
Douglas Mental Health University Institute
1995-2019
Université Laval
2001-2019
Jewish General Hospital
2019
Institut Universitaire de Gériatrie de Montréal
2007-2019
Université du Québec à Montréal
2019
McGill University
1992-2019
This study was undertaken to evaluate keratin 19 (K19) as a biochemical marker for skin stem cells in order address some long standing questions concerning these the field of cutaneous biology. We first used well-established mouse model enabling us identify [3H]thymidine-label-retaining cells. A site directed antibody raised against synthetic peptide K19. It reacted specifically with 40 kDa protein on immunoblotting. labelled bulge area outer root sheath by immunohistochemistry....
Optimal nutrition is essential for general well being, maintenance of physical and functional capacities prevention chronic disease in the elderly. The 5-year longitudinal study, NuAge, was designed to assess pivotal role on cognitive status, autonomy social functioning. A cohort 1793 men women, selected from three age groups (68–72, 73–77, 78–82) at recruitment, has been followed annually since 2003–2004. plurimethodological approach, including basic, clinical, epidemiologic, research used....
Abstract Background The exact impact of ageing on skeletal muscle phenotype and mitochondrial lipid content remains controversial, probably because physical activity, which greatly influences physiology, is rarely accounted for. present study was therefore designed to investigate the effects ageing, pre‐frailty phenotype, intramyocellular in men. Methods Recreationally active young adult (20–30 yo; YA); (ACT) sedentary (SED) middle‐age (50–65 MA‐ACT MA‐SED); older (65 + 65 ACT SED) pre‐frail...
Decline of physical function with age is associated substantial health consequences. Physical and psychological functioning linked, but the temporal nature this association remains unclear. Three-year follow-up data from men women ( n = 1,741), aged 68–82 years, in longitudinal study on nutrition successful aging (NuAge; Québec, Canada) were used. Growth curve modeling was performed to examine trajectories a global performance score across time as conditioned by cognition depression....
Judicious food choices are of prime importance during aging. This study was conducted to identify individual and collective attributes determining global diet quality (DQ). Participants were 1,793 adults (52% women) from the NuAge on nutrition successful Subjects aged 67 84 years in relatively good health recruited Québec Medicare Database. Sociodemographic, affective, cognitive data, conditions, perceived physical functional status, dietary habits community resources obtained using...
Aging is associated with a progressive decline in muscle mass and strength, process known as sarcopenia. Evidence indicates that mitochondrial dysfunction plays causal role sarcopenia suggests alterations dynamics/morphology may represent an underlying mechanism. Caloric restriction (CR) amongst the most efficient non-pharmacological interventions to attenuate rodents thought exert its beneficial effects by improving function. However, CR on morphology dynamics, especially aging muscle,...
The 4 kDa beta-amyloid (A beta) protein, a major component of cerebral and cerebrovascular plaques in Alzheimer's disease (AD), is derived from the proteolytic cleavage larger, membrane-bound precursor, A beta precursor protein (APP). Until recently, it was assumed that an aberrant AD-specific proteolysis generated peptides, which subsequently could initiate and/or contribute to pathological cascade leading plaque formation losses selected neuronal populations, including basal forebrain...