A5034307714- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Nutrition and Health in Aging
- Autophagy in Disease and Therapy
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Body Composition Measurement Techniques
- Diet and metabolism studies
- Physical Activity and Health
- Genetic Neurodegenerative Diseases
- Cardiovascular Function and Risk Factors
- Metabolism and Genetic Disorders
- Intensive Care Unit Cognitive Disorders
- Cardiac electrophysiology and arrhythmias
- Exercise and Physiological Responses
- ATP Synthase and ATPases Research
- Stress Responses and Cortisol
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metabolomics and Mass Spectrometry Studies
- Cerebral Palsy and Movement Disorders
- Long-Term Effects of COVID-19
- Parkinson's Disease Mechanisms and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Sirtuins and Resveratrol in Medicine
Université du Québec à Montréal
2016-2025
Institut Universitaire de Gériatrie de Montréal
2016-2025
McGill University
2011-2025
Christie (Canada)
2013-2025
McGill University Health Centre
2013-2024
Quebec Rehabilitation Research Network
2018-2024
Centre de Résonance Magnétique des Systèmes Biologiques
2009-2013
Centre National de la Recherche Scientifique
2006-2013
Royal Victoria Hospital
2011
Université de Bordeaux
2006-2010
// Jean-Philippe Leduc-Gaudet 1,2,3 , Martin Picard 4 Félix St-Jean Pelletier 1 Nicolas Sgarioto Marie-Joëlle Auger Joanne Vallée 5 Richard Robitaille 5,6 David H. St-Pierre and Gilles Gouspillou 1,2,7 Département des Sciences de l’Activité Physique, Faculté Sciences, UQAM, Montréal, Canada 2 Groupe Recherche en Activité Physique Adaptée, 3 Centre du CHU Sainte-Justine, The Center for Mitochondrial Epigenomic Medicine,...
Mitochondrial dysfunction is implicated in skeletal muscle atrophy and with aging, strong support for an increased mitochondrial-mediated apoptosis sedentary rodent models. Whether this applies to aged human unknown, nor it clear whether these changes are caused by behavior. Thus, we examined mitochondrial function [respiration, reactive oxygen species (ROS) emission, calcium retention capacity (CRC)] permeabilized myofibers obtained from vastus lateralis biopsies of healthy physically...
With aging, most skeletal muscles undergo a progressive loss of mass and strength, process termed sarcopenia. Aging-related defects in mitochondrial energetics have been proposed to be causally involved However, changes muscle oxidative phosphorylation with aging remain highly controversial issue, creating pressing need for integrative approaches determine whether bioenergetics are impaired aged muscle. To address this was first investigated vivo the gastrocnemius adult (6 months) (21 male...
Abstract Background The exact impact of ageing on skeletal muscle phenotype and mitochondrial lipid content remains controversial, probably because physical activity, which greatly influences physiology, is rarely accounted for. present study was therefore designed to investigate the effects ageing, pre‐frailty phenotype, intramyocellular in men. Methods Recreationally active young adult (20–30 yo; YA); (ACT) sedentary (SED) middle‐age (50–65 MA‐ACT MA‐SED); older (65 + 65 ACT SED) pre‐frail...
PGC-1α regulates critical processes in muscle physiology, including mitochondrial biogenesis, lipid metabolism and angiogenesis. Furthermore, was suggested as an important regulator of fiber type determination. However, whether a type-specific content exists, relates to basal levels content, such relationships are preserved between humans classically used rodent models all questions that have been either poorly addressed or never investigated. To address these issues, we investigated the its...
Key points Recent evidence suggests that impaired mitophagy, a process in charge of removing damaged/dysfunctional mitochondria and part regulated by Parkin, could contribute to the ageing‐related loss muscle mass function. In present study, we show Parkin overexpression attenuates strength unexpectedly causes hypertrophy adult skeletal muscles. We also leads increases mitochondrial content enzymatic activities. Finally, our results protects from markers oxidative stress, fibrosis apoptosis....
Key points Mitochondria are frequently implicated in the ageing of skeletal muscle, although role denervation modulating mitochondrial function muscle is unknown. We show that increased sensitivity to apoptosis initiation occurs prior evidence persistent and thus a primary defect worthy therapeutic targeting. However, at more advanced age, changes markedly impacted by sporadic myofibre denervation, suggesting mitochondrion may be less viable target. Abstract Experimental modulates function,...
Parkin, an E3 ubiquitin ligase encoded by the Park2 gene, has been implicated in regulation of mitophagy, a quality control process which defective mitochondria are degraded. The exact physiological significance Parkin regulating mitochondrial function and contractility skeletal muscle remains largely unexplored. Using Park2-/- mice, we show that ablation causes decrease specific force, severe respiration, uncoupling increased susceptibility to opening permeability transition pore. These...
The maintenance of optimal mitochondrial content and function is critical for muscle health. Mitochondrial dynamics play key roles in quality control; however, the exact role that fission plays skeletal health remains unclear. Here we report knocking down Drp1 (a protein regulating fission) 4 months adult mouse resulted severe atrophy (40-50%). knockdown also led to a reduction ADP-stimulated respiration, an increase markers impaired autophagy increased regeneration, denervation, fibrosis...
Abstract Autophagy is a critical process in the regulation of muscle mass, function and integrity. The molecular mechanisms regulating autophagy are complex still partly understood. Here, we identify characterize novel FoxO-dependent gene, d230025d16rik which named Mytho (Macroautophagy YouTH Optimizer), as regulator skeletal integrity vivo. significantly up-regulated various mouse models atrophy. Short term depletion MYTHO mice attenuates atrophy caused by fasting, denervation, cancer...
Abstract Aim Sarcopenia, the aging‐related loss of muscle mass and function, is a debilitating process negatively impacting quality life affected individuals. Although mechanisms underlying sarcopenia are incompletely understood, impairments in mitochondrial dynamics, including fusion, have been proposed as contributing factor. However, potential upregulating fusion proteins to alleviate effects aging on skeletal muscles remains unexplored. We therefore hypothesized that overexpressing...
Significance Mitochondrial dysfunction is associated with type II diabetes and metabolic syndrome, but whether it cause or consequence debated. By showing that increased mitochondrial respiration can impart glucose tolerance, insulin sensitivity, resistance to high fat diet (HFD) toxicity, we provide evidence mitochondria contributes the etiology of disease. Inactivation adenine nucleotide translocator isoform 1 (ANT1) results in proliferation partially uncoupled muscle respiration, creating...
Abstract Anticancer treatments for childhood acute lymphoblastic leukaemia (ALL) are highly effective but now implicated in causing impaired muscle function long-term survivors. However, no comprehensive assessment of skeletal mitochondrial functions survivors has been performed and the presence persistent chemotherapy-induced dysfunction remains a strong possibility. Non-tumour-bearing mice were treated with two drugs that have used frequently ALL treatment (doxorubicin dexamethasone) up to...
Aging is associated with a progressive decline in muscle mass and strength, process known as sarcopenia. Evidence indicates that mitochondrial dysfunction plays causal role sarcopenia suggests alterations dynamics/morphology may represent an underlying mechanism. Caloric restriction (CR) amongst the most efficient non-pharmacological interventions to attenuate rodents thought exert its beneficial effects by improving function. However, CR on morphology dynamics, especially aging muscle,...
The purpose of this study was to investigate the accuracy 3 recently released wrist-worn devices (Apple Watch 6, Polar Vantage V and Fitbit Sense) for heart rate energy expenditure during various activities. population consisted 60 young healthy individuals (30 men 30 women; age: 24.9 ± 3.0 years, BMI: 23.1 2.7 kg/m2). Heart were measured using H10 Metamax 3B, respectively (reference measures) as well with 5 different activities (sitting, walking, running, resistance exercises cycling)....
Autophagy is an important proteolytic pathway in skeletal muscles. The roles of muscle fiber type composition and oxidative capacity remain unknown relation to autophagy. diaphragm (DIA) a fast-twitch with high capacity, the tibialis anterior (TA) low soleus (SOL) slow-twitch capacity. We hypothesized that major determinant autophagy Following acute (24 h) starvation adult C57/Bl6 mice, each was assessed for compared controls. measured by monitoring autophagic flux following leupeptin (20...
Eccentric ergometer training (EET) is increasingly being proposed as a therapeutic strategy to improve skeletal muscle strength in various cardiorespiratory diseases, due the principle that lengthening actions lead high force-generating capacity at low cardiopulmonary load. One clinical population may particularly benefit from this chronic obstructive pulmonary disease (COPD), ventilatory constraints and locomotor dysfunction often limit efficacy of conventional exercise rehabilitation...
Abstract GDF15 (growth differentiation factor 15) is a marker of cellular energetic stress linked to physical-mental illness, aging, and mortality. However, questions remain about its dynamic properties measurability in human biofluids other than blood. Here, we examine the natural dynamics psychobiological regulation plasma saliva four studies representing 4,749 samples from 188 individuals. We show that protein detectable (8% concentration), likely produced by salivary glands secretory...