A5067633732- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Regulation of Appetite and Obesity
- Diabetes Management and Research
- Mitochondrial Function and Pathology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- GDF15 and Related Biomarkers
- Acupuncture Treatment Research Studies
- Circadian rhythm and melatonin
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Complementary and Alternative Medicine Studies
- Metabolism and Genetic Disorders
- Cancer-related cognitive impairment studies
- Heart Rate Variability and Autonomic Control
- Neuropeptides and Animal Physiology
- Nausea and vomiting management
- Adipokines, Inflammation, and Metabolic Diseases
Columbia University
2021-2024
Columbia University Irving Medical Center
2023-2024
University of Pennsylvania
2019-2021
Evolved limits to the human energy budget force body-brain system operate an economy of energy. To survive and thrive, organism’s limited internal energetic resources are dynamically reallocated by constraints that trade-offs from organelle-to-organism. We propose occur between three main classes processes: 1) Vital, 2) Stress, 3) Growth, Maintenance Repair (GMR). Competing demands for these processes exist within a hierarchy needs where more “urgent” vital- stress-related functions...
Abstract A growing appreciation of the overlapping neuroendocrine mechanisms controlling energy balance has highlighted combination therapies as a promising strategy to enhance sustained weight loss. Here, we investigated whether amylin- and glucagon-like-peptide-1 (GLP-1)-based produce greater food intake- body weight-suppressive effects compared monotherapies in both lean diet-induced obese (DIO) rats. In chow-maintained rats, systemic amylin GLP-1 combine reduce meal size. Furthermore,...
Abstract GDF15 (growth differentiation factor 15) is a marker of cellular energetic stress linked to physical-mental illness, aging, and mortality. However, questions remain about its dynamic properties measurability in human biofluids other than blood. Here, we examine the natural dynamics psychobiological regulation plasma saliva four studies representing 4,749 samples from 188 individuals. We show that protein detectable (8% concentration), likely produced by salivary glands secretory...
Glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. Notably, these behavioral effects are caused by direct central GLP-1R activation. Herein, we describe the creation of a agonist conjugate with modified brain penetrance that enhances GLP-1R-mediated glycemic control without inducing vomiting. Covalent attachment exendin-4 (Ex4) dicyanocobinamide (Cbi), corrin ring containing...
Abstract Background/objectives The murine postnatal leptin surge occurs within the first 4 weeks of life and is critical for neuronal projection development hypothalamic feeding circuits. Here we describe influence nutritional status on timing magnitude in mice. Methods Plasma concentrations were measured 1–3 times per week C57BL/6J pups reared litters adjusted to 3 (small), 7–8 (normal), or 11–12 (large) dam fed breeder chow raised by dams high-fat diet (HFD) ad libitum starting either...
To develop a conjugate of vitamin B12 bound to the glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (Ex4) that shows reduced penetrance into central nervous system while maintaining peripheral glucoregulatory function.We evaluated whether Ex4 (B12-Ex4) improves glucose tolerance without inducing anorexia in Goto-Kakizaki (GK) rats, lean type 2 diabetes model an understudied but medically compromised population patients requiring effects GLP-1R agonists anorexia. We also utilized...
Abstract Mitochondria are key energy transforming organelles in mammalian cells. However, how defects oxidative phosphorylation (OxPhos) and other mitochondrial functions influence whole-body expenditure (EE) has not been rigorously studied. Cellular organismal responses to OxPhos likely involve a combination of functional downregulation conserve compensatory upregulation stress responses. If the cost exceeds potential savings downregulation, as recent work suggests, result would be an...
Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage accumulation increases cellular expenditure, yet whole-body expenditure is stable or decreases with age. We resolve this apparent contradiction by positioning the brain as mediator and broker economy of within organism. As somatic tissues accumulate over time, costly intracellular stress responses are activated, causing aging/senescent cells to secrete cytokines that convey increased demand (hypermetabolism)...
Nausea and vomiting are consistently identified among the most distressing side effects of chemotherapy. In recent years, Olanzapine (OLZ) treatment was added to anti-emetic guidelines as a for chemotherapy-induced nausea (CINV), despite little available data supporting mechanism behind positive benefits drug. Here, we examine whether OLZ reduces cisplatin on food intake pica behavior in rats (i.e., kaolin intake, proxy nausea/emesis). Behavioral experiments tested systemic or hindbrain...