A5101483119- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Acupuncture Treatment Research Studies
- Aquaculture disease management and microbiota
- Healthcare and Venom Research
- Sepsis Diagnosis and Treatment
- Virology and Viral Diseases
- Streptococcal Infections and Treatments
- Machine Learning in Healthcare
- Neonatal and fetal brain pathology
- Osteoarthritis Treatment and Mechanisms
- Olfactory and Sensory Function Studies
- Respiratory viral infections research
- Traditional Chinese Medicine Analysis
- Identification and Quantification in Food
- Advanced biosensing and bioanalysis techniques
- Adolescent Sexual and Reproductive Health
- Congenital Anomalies and Fetal Surgery
- Immune responses and vaccinations
- Genomic variations and chromosomal abnormalities
- Microbial infections and disease research
- Nanoplatforms for cancer theranostics
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Influenza Virus Research Studies
Guangdong Provincial People's Hospital
2024
Beijing University of Posts and Telecommunications
2024
Columbia University Irving Medical Center
2024
Tongji Hospital
2020-2023
Shanghai University of Traditional Chinese Medicine
2008-2023
Shuguang Hospital
2008-2023
Second Hospital of Anhui Medical University
2022-2023
Anhui Medical University
2022-2023
Huazhong University of Science and Technology
2020-2023
Fuyang City People's Hospital
2023
Abstract GDF15 (growth differentiation factor 15) is a marker of cellular energetic stress linked to physical-mental illness, aging, and mortality. However, questions remain about its dynamic properties measurability in human biofluids other than blood. Here, we examine the natural dynamics psychobiological regulation plasma saliva four studies representing 4,749 samples from 188 individuals. We show that protein detectable (8% concentration), likely produced by salivary glands secretory...
The primary pathology of rheumatoid arthritis (RA) involves the invasion extracellular matrix (ECM) articular cartilage by inflammation-activated fibroblast-like synoviocytes (FLS), a process targeted most RA therapeutic drugs. However, absence an efficient in vitro model for evaluating FLS hinders relevant drug screening and mechanism research. To address this, novel three-dimensional (3D) chondrocytic spheroid that mimics ECM has been developed, along with corresponding indices to quantify...
Embryonic chromosomal abnormality is one of the significant causative factors early pregnancy loss. Our goal was to evaluate clinical utility next-generation sequencing (NGS) technology in identifying anomalies associated with first-trimester In addition, we attempted provide fertility guidance couples anticipating a successful pregnancy. A total 1,010 miscarriage specimens were collected between March 2016 and January 2019 from women who suffered Total DNA isolated products conception, NGS...
To explore the effect of long-term traditional Chinese medicine (TCM) treatment on survival time colorectal cancer (hereinafter referred to as CRC).Our clinical study included patients who were diagnosed with CRC clinically or pathologically. Patients divided into TCM group and control according whether modified Anti-cancer Decoction II Formula was applied for more than six months. Propensity score matching PSM) used further balance covariates between groups. One-year six-year...
Dramatic progress has occurred in neonatal intensive care tertiary centers mid-eastern China. We investigated the characteristics of respiratory failure (NRF) including incidence, management, outcomes and costs 14 units (NICUs) Hebei, a province at an intermediate economic level Over period 12 consecutive months 2007–2008, perinatal data were collected prospectively from all NICU admissions (n = 11,100). NRF was defined as severe hypoxemia requiring support for more than 24 h, diagnosed...
Abstract Objectives Streptococcus pneumoniae (S. pneumoniae) is an important commensal and pathogenic bacterium responsible for pneumonia, meningitis other invasive diseases. Pneumolysin (PLY) the major virulence factor that contributes significantly to interaction between S. host. Key findings In this study, results of antibacterial analysis, haemolysis test Western blotting assay showed acacetin inhibited PLY-mediated pore-forming activity caused by culture precipitates purified PLY...
In traditional Chinese medicine, the syndrome of qi vacuity means that patient's body has a low level energy to react stress. Recently, we used score, QV by scaling severity symptoms and signs in patients with tiredness. The aim this study was investigate relationship between score skin electrical conductance One hundred forty-three healthy controls 103 tiredness were involved. Each subject received weak stimulation constant voltage (1.75 volt), measured two different limbs. mean value among...
Qi vacuity (QV) is defined by traditional Chinese medicine as a loss of energy in the human body. An objective method for detecting QV was not available until recently, however. The automatic reflective diagnosis system (ARDK) device that detects bioenergy through measuring skin conductance at 24 special acupoints on wrists and ankles.This study used ARDK to measure 193 patients with 89 sex- age-matched healthy controls investigate whether useful QV. Patients diagnosed have three or more...
Listeria monocytogenes is a ubiquitous Gram-positive foodborne pathogen that responsible for listeriosis in both humans and several animal species. The bacterium secretes pore-forming cholesterol-dependent cytolysin, listeriolysin O (LLO), major virulence factor involved the activation of cellular processes. ability LLO to lyse erythrocytes measure activity. We used hemolytic activity assay screen inhibitors. Acacetin was found be an inhibitor, which di-hydroxy mono-methoxy flavone present...
Avibacterium paragallinarum, the causative agent of infectious coryza, is known to release outer membrane vesicles (OMVs). The composition, bioactivities and functional properties OMVs Av. paragallinarum were investigated in this study. Following extraction purification, observed be spherical shape, with diameters ranging from 20 300 nm. contained high levels endotoxin as well genomic DNA. molecular weights OMV-contained protein fragments mostly concentrated at 65 kD 13 kD. components OMV...
This study aims to observe the changes in quality of life as well anxiety among lung cancer patients before and after chemotherapy. work also explore effect chemotherapy on anxiety.Fifty-eight were evaluated based clinical outcomes, EORTC QLQ-C30, SAS questionnaires chemotherapy, one week two courses four chemotherapy.Before functioning scale, fatigue, dyspnoea scores high, rate was 56%, while score 49.54±5.64. Anxiety found be positively correlated with insomnia (P<0.05). After decreased,...
Hepatic ischemia-reperfusion (IR) injury is characterized by severe inflammation and cell death. However, very few effective therapies are presently available for hepatic IR treatment. Here, we reported a protective function the underlying mechanism of myotubularin-related protein 14 (MTMR14) during injury. Hepatocyte-specific MTMR14 knockout (HKO) transgenic (TG) mice were subjected to operation explore in vivo. Primary hepatocytes isolated from MTMR14-HKO MTMR14-TG hypoxia/reoxygenation...
Abstract To investigate the relationship between life style, medication adherence and development of in-stent restenosis after percutaneous coronary intervention. A total 230 patients with heart disease were recruited investigated semi-quantitative food frequency questionnaire, international physical activity screening tool for psychological Morisky questionnarie. Logistic regression was used statistical analysis. analysis revealed that there positive correlation score (OR = 1.503), anger...
Preimplantation genetic testing plays a critical role in enabling balanced translocation carrier to obtain the normal embryo. Identifying precise breakpoints for carriers with phenotypic abnormity, allows us reveal disrupted genes. In this study, seemingly 46, XX, t (3; 6) (q29; q26) was first detected using conventional karyotype analysis. To locate breakpoints, whole genomes of DNA were sequenced based on nanopore GridION platform, and bioinformatic analyses further confirmed by...