A5101585607- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- Sepsis Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Global Maternal and Child Health
- Neonatal and Maternal Infections
- Birth, Development, and Health
- Maternal and Perinatal Health Interventions
- Nitric Oxide and Endothelin Effects
- Infant Development and Preterm Care
- Asthma and respiratory diseases
- Neonatal and fetal brain pathology
- Child and Adolescent Health
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Cardiac Imaging and Diagnostics
- Infant Nutrition and Health
- Coronary Interventions and Diagnostics
- Respiratory and Cough-Related Research
- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Intestinal Malrotation and Obstruction Disorders
- Inflammation biomarkers and pathways
Qingdao University
2024
Qingdao Municipal Hospital
2024
Children's Hospital of Fudan University
2014-2023
National Health and Family Planning Commission
2013-2023
Shenzhen Second People's Hospital
2007-2023
Hebei Medical University
2022
China Academy of Chinese Medical Sciences
2022
Xuzhou Medical College
2022
Xiangya Hospital Central South University
2022
Chinese Academy of Sciences
2022
We retrospectively investigated incidence, morbidity, and mortality of neonatal respiratory failure (NRF) in China, with special emphasis on surfactant treated very immature infants.NRF was defined as hypoxemia requiring mechanical ventilation and/or nasal continuous positive airway pressure for at least 24 hours.There were 6864 cases NRF, composing 19.7% total admissions to 55 NICUs 2008. Of these cases, 62.8% preterm, 16.4% low birth weight (VLBW, <1500 g). The primary diseases distress...
Objective: To determine the prevalence, treatment, and outcomes of sepsis at regional hospitals in Huai'an, Jiangsu, China. Design: Prospective data registry using a descriptive clinical epidemiologic approach through collaborative network. Setting: Pediatric departments 11 city county referral serving 843,000 children (exclusive neonates). Subjects: All admissions (n = 27,836) patients from 28 days to 15 years old September 1, 2010, August 31, 2011. Interventions: None. Measurements Main...
Nearly mature newborn rabbits (gestational age 29.5 days) were tracheotomized at birth and received, via the tracheal cannula, 6 ml/kg body weight of a filtered saline suspension human meconium, 65 or 130 mg/ml. Animals kept in plethysmographs ventilated for 60 min with standardized tidal volume (8-10 ml/kg). Aspiration meconium caused, both groups, statistically significant reduction lung-thorax compliance, elevated PCO<sub>2</sub> heart blood reduced alveolar density (Vv)...
OBJECTIVES. In the past decade, neonatal special care services in China have been established, during which time various therapies for respiratory failure introduced. The objective of this study was to investigate incidence, management, outcome, and cost treated by mechanical ventilation 23 tertiary NICUs major hospitals southeastern midwestern China. METHODS. Data were collected over 12 consecutive months from 2004 2005 neonates with failure. Eligible infants those who required endotracheal...
Abstract Aim: To investigate the incidence, clinical management, mortality and its risk factors, major outcome costs of acute hypoxemic respiratory failure (AHRF) distress syndrome (ARDS) in a Chinese network 26 paediatric intensive care unit (PICU). Methods: In consecutive 12‐month period, AHRF ARDS were identified followed up for 90 days or until death discharge. Results: From total 11 521 critically ill patients, 461 which 306 developed (66.4%), resulting incidences 4% 2.7%, respectively,...
Objective: To estimate birth population-based perinatal-neonatal mortality and preterm rate in China from a regional survey 2010.Study design: Data of total births 2010 obtained 151 level I–III hospitals Huai'an, Jiangsu, were prospectively collected analyzed.Results: From 61 227 registries (including 60 986 live 241 stillbirths), we derive 11.3‰ (of 5.4 million population), male-to-female ratio 116:100 valid data 615 newborns. Mean weight (BW) was 3441 ± 491 g with 13.6% macrosomia. Low BW...
Objectives: We investigated the incidence and outcome of clinical histological chorioamnionitis (CA) associated risk factors in an emerging provincial perinatal center 2014–2015.Study design: Based on suspected proven infection third trimester pregnancy, placenta accessories from singleton deliveries were routinely examined histologically. The CA fetal neonatal compared by total deliveries.Results: Of 14,166 12 months, inflammation found 373 out 2372 (15.7%) placentas subjected to...
Objectives: We aimed to evaluate the efficacy of respiratory support and surfactant in incidence, management outcome neonatal hypoxemic failure (NRF) Chinese emerging regional neonatal–perinatal care system era universal health insurance policy.Study design: Clinical data NRF were prospectively collected 12 consecutive months from 2011 2012 intensive units (NICU) major cities Northwest China. was defined as hypoxemia requiring nasal continuous positive airway pressure (nCPAP) or...
Neonatal mortality reduction in China over past two decades was reported from nationwide sampling surveys, however, how high risk pregnancy affected neonatal outcome is unknown. The objective of this study to explore relations complications and outcomes a regional birth population. In prospective, cross-sectional survey complete population-based data file 151 level I-III hospitals Huai'an region 2010, were analyzed for perinatal morbidity association with maternal characteristics, hospital...
<i>Aims</i>—To study the influence of surfactant on lung function and bacterial proliferation in immature newborn rabbits with experimental group B streptococcal (GBS) pneumonia. <h3>METHODS</h3> Preterm rabbit fetuses (gest-ational age 28 days) underwent tracheotomy were mechanically ventilated a warmed body plethysmograph that permitted measurement lung-thorax compliance. Fifteen minutes after onset ventilation animals received either GBS or saline intratracheally; at 30 minutes, bolus 200...
Dramatic progress has occurred in neonatal intensive care tertiary centers mid-eastern China. We investigated the characteristics of respiratory failure (NRF) including incidence, management, outcomes and costs 14 units (NICUs) Hebei, a province at an intermediate economic level Over period 12 consecutive months 2007–2008, perinatal data were collected prospectively from all NICU admissions (n = 11,100). NRF was defined as severe hypoxemia requiring support for more than 24 h, diagnosed...
Abstract Background Despite 15–17 millions of annual births in China, there is a paucity information on prevalence and outcome preterm birth. We characterized the hospitalized infants by gestational age (GA) Huai’an 2015, an emerging prefectural region China. Methods Of 59,245 regional total births, clinical data 2651 1941 neonates were extracted from Women Children’s Hospital (HWCH) non-HWCH hospitals 2018–2020. Preterm prevalence, morbidity mortality rates compared hospital categories GA...
Abstract Aim: To describe rates of neonatal mortality, low birthweight (LBW), preterm birth and small for gestational age (SGA), relate outcome to ethnicity perinatal risk factors liveborn infants hospital deliveries in Lhasa. The differences these variables between ethnic Tibetans non‐Tibetans were also studied. Methods: Data prospectively collected on the all born four hospitals urban area Lhasa, Tibet, 2005. Result: A total 2540 recorded. LBW, SGA 13.6%, 5.7% 22.2%, respectively. Neonatal...
Background Nitric oxide (NO) plays an important role in mobilization of endothelial progenitor cells (EPCs). We hypothesized that inhaled NO (iNO) would induce EPC and therefore promote lung repair acute respiratory distress syndrome (ARDS). Methodology/Principal Findings Healthy piglets were randomized into four groups (n = 6): Control (Con; mechanical ventilation only); ARDS (established by oleic acid infusion ventilation); plus granulocyte-colony stimulating factor (G-CSF; 10 µg/kg/d...
Objective: This survey followed the birth population-based study conducted in 2010 Huai'an, Jiangsu Province, with aim to estimate perinatal-neonatal mortality and preterm rate emerging regions similar maternal-fetal neonatal care conditions China.Materials methods: Data of total births 2015 were prospectively collected by regional perinatal network collaboration a subprovincial region population 5,644,500 gross domestic production 9082 USD per capita.Results: The 59,424 registries...