A5100460760- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational exposure and asthma
- Nosocomial Infections in ICU
- Gastrointestinal Bleeding Diagnosis and Treatment
- Polymer crystallization and properties
- Mechanical Circulatory Support Devices
- biodegradable polymer synthesis and properties
- Neonatal and fetal brain pathology
- Congenital Heart Disease Studies
- Sarcoidosis and Beryllium Toxicity Research
- Epigenetics and DNA Methylation
- Microbial Metabolic Engineering and Bioproduction
- Child and Adolescent Health
- Intensive Care Unit Cognitive Disorders
- Neonatal and Maternal Infections
- Catalysis for Biomass Conversion
- Cardiac Arrest and Resuscitation
- Gastrointestinal disorders and treatments
- Asthma and respiratory diseases
- Biofuel production and bioconversion
- Chronic Obstructive Pulmonary Disease (COPD) Research
Air Force General Hospital PLA
2024
Huaibei Normal University
2009-2023
Second People’s Hospital of Huai’an
2022
Xuzhou Medical College
2022
Second Hospital of Shandong University
2017-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Stanford University
2014
Children's Hospital of Chongqing Medical University
2014
Chongqing Medical University
2014
Pediatrics and Genetics
2013
OBJECTIVE: Twin studies suggest that heritability of moderate-severe bronchopulmonary dysplasia (BPD) is 53% to 79%, we conducted a genome-wide association study (GWAS) identify genetic variants associated with the risk for BPD. METHODS: The discovery GWAS was completed on 1726 very low birth weight infants (gestational age = 250–296/7 weeks) who had minimum 3 days intermittent positive pressure ventilation and were in hospital at 36 weeks’ postmenstrual age. At age, BPD cases (n 899)...
Idiopathic pulmonary fibrosis (IPF) is a gradual lung disease with survival of less than 5 years post-diagnosis for most patients. Poor molecular description IPF has led to unsatisfactory interpretation the pathogenesis this disease, resulting in lack successful treatments. The objective study was discover novel noninvasive biomarkers diagnosis IPF. We employed coupled isobaric tag relative and absolute quantitation (iTRAQ)-liquid chromatography–tandem mass spectrometry (LC–MS/MS) approach...
Objectives: We aimed to evaluate the efficacy of respiratory support and surfactant in incidence, management outcome neonatal hypoxemic failure (NRF) Chinese emerging regional neonatal–perinatal care system era universal health insurance policy.Study design: Clinical data NRF were prospectively collected 12 consecutive months from 2011 2012 intensive units (NICU) major cities Northwest China. was defined as hypoxemia requiring nasal continuous positive airway pressure (nCPAP) or...
Background: To compare the safety and effectiveness of nasal noninvasive high- frequency oscillatory ventilation (NHFOV) duo positive airway pressure (DuoPAP) applications in preterm babies with respiratory distress syndrome (RDS). Methods: This was a randomized controlled trial. Forty-three premature infants RDS treated neonatal intensive care unit Huaibei Maternal Child Health Hospital from January 2020 to November 2021 were selected as research participants. They randomly divided into...
Abstract Background Admission hypothermia (AH, < 36.5℃) remains a major challenge for global neonatal survival, especially in developing countries. Baseline research shows nearly 89.3% of very low birth weight (VLBW, 1500 g) infants suffer from AH China. Therefore, prospective multicentric quality improvement (QI) initiative to reduce regional and improve outcomes among VLBW neonates was implemented. Methods The study used sequential Plan—Do—Study—Act (PDSA) approach. Clinical data were...
Abstract Background To explore the prevalence, outcome and perinatal risks of neonatal hypoxemic respiratory failure (NRF) in a survey all livebirths from regional network perinatal-neonatal care during transition period after 5-year universal health insurance implemented China. Methods Clinical data morbidities Huai’an were retrospectively collected database as vital statistics 2015. NRF was defined hypoxemia requiring continuous positive airway pressure (CPAP) and/or mechanical ventilation...
Abstract Background Published guidelines on decision-making and resuscitation of extremely preterm infants primarily focus high-income countries. For rapidly industrializing ones like China, there is a lack population-based data for informing prenatal management practice guidelines. Methods The Sino-northern Neonatal Network conducted prospective multi-centre cohort study between 1 January 2018 31 December 2021. Infants with gestational age (GA) 22 (postnatal in days = 0) 28 6) admitted to...
Abstract The spherulitic structure and morphology of poly(3‐hydroxybutyrate) (PHB) thin films crystallized from the melt were observed with a polarizing optical microscope. Depending on thickness PHB film crystallization temperature, banded nonbanded spherulites could form. Reducing thin‐film temperature was favorable for formation structure. transition to related ratio rate diffusion rate. mechanism examined discontinuity growth theory. A depletion zone considered appear periodically at...
Pulmonary hemorrhage (PH) in neonates is a life-threatening respiratory complication. We aimed to analyze the perinatal risk factors and morbidity with PH among very preterm infants large multicenter study.This was case-control study based on prospective cohort. Participants included 3,680 in-born gestational age at 24-32 weeks (birth weight <1,500 g) who were admitted between January 1, 2019, October 31, 2021. All divided into two groups, namely, no-PH ratio of 1:2 according following...
Intramural duodenal hematoma (IMDH) is relatively uncommon and typically arises following blunt abdominal trauma, particularly among children.1 Abdominal pain, vomiting, upper discomfort are common clinical manifestations of IMDH. Treatment options for IMDH vary depending on the patient's symptoms, manifestations, presence complications. 2 This article presents a case intramural involving descending horizontal segments duodenum.
The less invasive surfactant application (LISA) technology has been widely used to manage breathing in premature infants. Premature infants with respiratory distress syndrome (RDS) were retrospectively analyzed and divided into 2 groups according the drug delivery methods used: LISA versus traditional pulmonary injection (INSURE). decrease of transcutaneous saturation (T c SO2) heart rate during group was higher than that INSURE ( P < .05). Between groups, there no significant difference...
Acute respiratory failure is the common critical syndromeon clinic, it has a substantial mortality rate.Extracorporeal carbon dioxide removal(ECCO2R)systems can provide partial support for patients with hypercapnicacute failure.ECCO2R systems remove and limited oxygenation.ECCO2R been proposed hypercapnic to reduce parameter mechanical ventilation lung injury caused by ventilation. Key words: Extracorporeal carbondioxide removal; Acute
Abstract Background: Admission hypothermia (AH, <36.5℃) remains a major challenge for global neonate survival, especially in China. Due to high incidence of reginal AH, we developed prospective multicenter quality improvement (QI) initiative reduce regional AH and evaluate the impact on outcome among VLBW neonates. Methods: The study used sequential Plan - Do Study Act (PDSA) approach. Clinical data were collected prospectively with 5 NICUs from Sino-Northern Neonatal Network (SNN) Bundle...