A5013002476- Cervical Cancer and HPV Research
- Hepatitis B Virus Studies
- Genital Health and Disease
- Cerebral Palsy and Movement Disorders
- Neonatal Respiratory Health Research
- Atmospheric and Environmental Gas Dynamics
- Neonatal and fetal brain pathology
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Viral Infections and Immunology Research
- Infant Nutrition and Health
- Ubiquitin and proteasome pathways
- Risk and Safety Analysis
- Oil, Gas, and Environmental Issues
- Immunotherapy and Immune Responses
- Risk Perception and Management
- Protease and Inhibitor Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Oil Spill Detection and Mitigation
- Bone and Dental Protein Studies
- Autophagy in Disease and Therapy
- Nitric Oxide and Endothelin Effects
- Congenital Diaphragmatic Hernia Studies
- Blood Coagulation and Thrombosis Mechanisms
Qilu Hospital of Shandong University
2020-2024
Shandong Provincial Hospital
2023
Shandong First Medical University
2023
Deyang Stomatological Hospital
2023
GlaxoSmithKline (Belgium)
2010-2022
Third Affiliated Hospital of Zhengzhou University
2012-2022
Anhui University of Traditional Chinese Medicine
2022
Xi'an Jiaotong University
2021-2022
Yichun University
2022
Neusoft (China)
2021
Preterm brain injury consists primarily of periventricular leukomalacia accompanied by elements gray-matter injury, and these injuries are associated with cerebral palsy cognitive impairments. Inflammation is believed to be an important contributing factor injuries. The aim this study was examine the immune response in a postnatal day (PND) 5 mouse model preterm induced hypoxia-ischemia (HI) that characterized focal white injury. C57Bl/6 mice at PND were subjected unilateral HI left carotid...
Flavonoids, a group of compounds mainly derived from vegetables and herbal medicines, share chemical resemblance to estrogen, indeed some which have been used as estrogen substitutes. In searching for possible functions flavonoids, the neuroprotective effect in brain could lead novel treatment, or prevention, neurodegenerative diseases. Here, different subclasses flavonoids were analyzed its inductive role neurite outgrowth cultured PC12 cells. Amongst tested flavonol aglycone, isorhamnetin...
This phase II/III, double-blind, randomized trial assessed the efficacy, immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in young Chinese women (ClinicalTrials.gov registration NCT00779766). Women aged 18-25 years from Jiangsu province were (1:1) to receive HPV (n = 3,026) or Al(OH)3 control 3,025) at months 0, 1 6. The primary objective was efficacy (VE) against HPV-16/18 associated 6-month persistent infection (PI) and/or cervical intraepithelial...
The relationship between genetic factors and the development of cerebral palsy (CP) has recently attracted much attention. Polymorphisms in genes encoding proinflammatory cytokines have been shown to be associated with susceptibility perinatal brain injury CP. Interleukin-6 (IL-6) is a cytokine that plays pivotal role neonatal injury, but conflicting results reported regarding association IL-6 single nucleotide polymorphisms (SNPs) purpose this study was analyze gene protein expression...
Current HPV vaccines do not protect against all oncogenic types. Following vaccination, type replacement may occur, especially if different types competitively interact during natural infection. Because of their common route transmission, it is difficult to assess interactions in observational studies. Our aim was evaluate the setting vaccine randomized controlled trials (RCTs).Data were pooled from Costa Rica Vaccine Trial (CVT; NCT00128661) and PATRICIA trial (NCT001226810)-two...
Abstract Background Cervical cancer is a major public health concern in China. We report the end‐of‐study results of phase II/III trial to assess efficacy, immunogenicity, and safety AS04‐human papillomavirus (HPV)‐16/18 vaccine Chinese women aged 18‐25 years followed for up 72 months after first vaccination. Results approximately 57 following vaccination have been previously reported. Methods Healthy 18‐25‐year‐old (N = 6051) were randomized (1:1) receive three doses AS04‐HPV‐16/18 or...
Identification of protective factors to prevent firefighters' anxiety and depression is meaningful. We explored whether emotion-regulation strategies mediate the relationship between personality traits among Chinese firefighters. Approximately, 716 firefighters were recruited completed Emotion Regulation Questionnaire (ERQ), Self-Rating Anxiety Scale (SAS), Depression (SDS), Big Five Inventory-2 (BFI-2) Scale. Results (N = 622) indicated that only negative emotionality could predict...
High-risk human papillomaviruses (hrHPV) cause anogenital and oropharyngeal cancers. HPV-16/18 virus-like particle vaccine formulated with an AS04 adjuvant is very efficacious against hrHPV associated precancers but the herd effects of different vaccination scenarios are not known. Our cluster randomized trial (NCT00534638) assesses overall vaccinating girls vs. boys. In two school-years (2007-2008 2008-2009) we invited 80,272 1992-1995 born early adolescents to a CRT in 33 communities...
Abstract In this study, we propose an adaptive multiscale ensemble (AME) learning approach, which consists of variational mode decomposition (VMD) and least square support vector regression (LSSVR) for seasonal trend forecasting tourist arrivals. the formulation AME original arrival series is decomposed into trend, seasonal, remaining volatility components. Then, ARIMA used to forecast component, SARIMA LSSVR The empirical results demonstrate that our proposed approach can achieve higher accuracy.
Abstract Aim: India has the highest number of annual incident cases and mortality rates for cervical cancer worldwide. This study was conducted to assess immunogenicity safety human papillomavirus (HPV)‐16/18 AS04‐adjuvanted vaccine in healthy Indian women aged 18–35 years old. Methods: double‐blind, randomized (1:1), controlled multicenter trial with two parallel groups, Vaccine Placebo included 354 subjects four centers across India. Subjects were given GlaxoSmithKline's HPV‐16/18 or...
Abstract We previously reported the results of a phase II/III, double‐blind, randomized controlled study in Chinese women (NCT00779766) showing 94.2% (95% confidence interval: 62.7–99.9) HPV‐16/18 AS04‐adjuvanted vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 1 or higher (CIN1+) and/or 6‐month (M) persistent infection (PI) with mean follow‐up <2 years, and immunogenicity until 7 months post‐dose 1. Here, we report safety from an event‐triggered analysis ~3 years...
Baseline human papillomavirus (HPV) prevalence and type distribution were evaluated in young Chinese women enrolled a clinical trial of an HPV vaccine (ClinicalTrials.gov registration NCT00779766). Cervical specimens blood samples collected at baseline from aged 18-25 years (n = 6,051) four sites across Jiangsu province. tested for DNA by SPF10 PCR-DEIA-LiPA25 version 1, HPV-16/18 type-specific polymerase chain reaction. Anti-HPV-16 anti-HPV-18 antibody titres quantified enzyme-linked...
Several studies have linked branched-chain amino acid (BCAA) metabolism disorders with autism spectrum disorder (ASD), but the results been inconsistent. The purpose of this study was to explore association between BCAA concentrations and risk ASD. A total 313 participants were recruited from two tertiary referral hospitals May 2018 July 2021. Concentrations BCAAs in dried blood spots analyzed using liquid chromatography-tandem mass spectrometry-based analysis. Multivariate analyses...
Osteopontin (OPN) is a highly phosphorylated sialoprotein and soluble cytokine that widely expressed in variety of tissues, including the brain. OPN OPN-derived peptides have been suggested to potential neuroprotective effects against ischemic brain injury, but their role preterm injury unknown. We used hypoxia-ischemia (HI)-induced model postnatal day 5 mice. were given intracerebroventricularly intranasally before HI. Brain was evaluated at 7 days after insults. There significant increase...
Cerebral palsy (CP) is a major cause of childhood disability in developed and developing countries, but the pathogenic mechanisms CP development remain largely unknown. Autophagy highly conserved cellular self-digestion damaged organelles dysfunctional macromolecules. Growing evidence suggests that autophagy-related gene 5 (ATG5)-dependent autophagy involved neural development, neuronal differentiation, neurological degenerative diseases. The aim this study was to analyze ATG5 protein...
Background. Staphylococcus epidermidis causes late-onset sepsis in preterm infants. activates host responses part via Toll-like receptor 2 (TLR2). Epidemiologic studies link bacteremia and neonatal brain injury, but direct evidence is lacking. Methods. Wild-type TLR2-deficient (TLR2−/−) mice were injected intravenously with S. at postnatal day 1 prior to measuring plasma cytokine chemokine levels, bacterial clearance, caspase-3 activation, white/gray matter volume, innate transcriptome....
This community-randomized controlled trial was initiated to assess the overall and herd effects of 2 different human papillomavirus (HPV) immunization strategies in over 80,000 girls boys aged 12–15 y 33 communities Finland (ClinicalTrials.gov NCT00534638). Overall, 14,838 adolescents received HPV-16/18 vaccine (2,440 12,398 girls) 17,338 hepatitis-B virus (HBV) (9,221 8,117 girls). In an interim analysis, safety assessed by active monitoring surveillance via health registry linkage. Active...
Vascular smooth muscle cells (VSMCs) have a remarkable degree of plasticity and in response to vascular injury, they can change dedifferentiated state that be typically seen cell cultures. Recently, Y27632, Rho kinase inhibitor, has been reported preferentially correct hypertension hypertensive rat model. We thus tested the hypothesis contraction cultured VSMCs might more dependent on function RhoA than fresh tissue. For this purpose, tissue-like ring preparation was made using porcine...
In previous research, we found that cell secretion from the adult lamprey supraneural body tissues possesses cytocidal activity against tumor cells, but protein with was unidentified. A novel immune (LIP) as defense molecule first purified and identified in jawless vertebrates (cyclostomes) using hydroxyapatite column Q Sepharose Fast Flow column. After LIP stimulation, morphological changes of cells were analysed measured whether vivo or vitro. induces remarkable including blebbing,...
1. An experiment was conducted to study the effect of thiram on liver antioxidant capacity and incidence tibial dyschondroplasia in broilers. 2. One hundred twenty Avian commercial broilers were allotted at random three treatments: control group, low group (50 mg/kg) high (100 mg/kg). 3. Blood samples collected determine activity AST (aspartate aminotransferase). At end trial, killed SOD (superoxide dismutase), GSH-Px (glutathione peroxidase) MDA (malondialdehyde) content, while right...
Objective:The study assessed the immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted cervical cancer vaccine in healthy Korean women aged 15-25 years.Methods: Phase IIIB, double-blind, randomised (2:1), multi-centre trial was conducted Korea from June 2007 to March 2008.The enrolled 225 HPV (N=149) placebo (N=76) groups who received three doses HPV-16/18 or (aluminium hydroxide) administered intramuscularly at 0, 1, 6 months were followed until one month post-dose...