A5101737086- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and Maternal Infections
- Congenital Diaphragmatic Hernia Studies
- Infant Nutrition and Health
- Birth, Development, and Health
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Neonatal and fetal brain pathology
- Cardiovascular Effects of Exercise
- Viral Infections and Immunology Research
- Preterm Birth and Chorioamnionitis
- Cardiac Imaging and Diagnostics
- Antibiotics Pharmacokinetics and Efficacy
- Neonatal Health and Biochemistry
- Neuroscience of respiration and sleep
- Antibiotic Use and Resistance
- Pregnancy and preeclampsia studies
- Heart Failure Treatment and Management
- Infant Health and Development
- Polysaccharides and Plant Cell Walls
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Fungal Biology and Applications
Shandong Provincial Hospital
2003-2024
Shandong University
2010-2024
Shandong First Medical University
2020-2024
Wuhan University
2009
University of Iowa
2009
Fudan University
2004-2007
Tokyo Institute of Technology
2004
Pediatric Oncology Group
2003
Two water-soluble derivatives, sulfated and carboxymethylated Ganoderma lucidem polysaccharides, coded as S-GL CM-GL, were prepared using derivatization of water-insoluble polysaccharides (GL-IV-I) extracted from the fruit body G. . The degree substitution (DS) CM-GL was 0.94 1.09, respectively. weight-average molecular mass (Mw) GL-IV-I, S-GL, determined with light scattering to be 13.3x10(4), 10.1x10(4), 6.3x10(4), inhibited in vitro proliferation Sarcoma 180 (S-180) tumor cells a...
Abstract Objectives We aimed to evaluate the risk factors for moderate-to-severe bronchopulmonary dysplasia (BPD) and focus on discussing its relationship with duration of initial invasive mechanical ventilation (IMV) in very preterm neonates less than 32 weeks gestational age (GA). Methods performed a prospective cohort study involving infants born at 23–31 GA who were admitted 47 different neonatal intensive care unit (NICU) hospitals China from January 2018 December 2021. Patient data...
BackgroundPrevious antibiotic exposure is an important risk factor for invasive fungal infection (IFI). Antibiotic overexposure common in lower-income countries; however, multi-centre studies concerning IFI relation to are scarce.AimThis prospective, matched case–control study explored the correlation of and very preterm infants or very-low-birthweight admitted 23 tertiary hospitals China between 2018 2021.MethodsUsing a 1:2 design gestational age, birth weight early-onset sepsis (yes/no),...
The objective of this prospective, multicentre, observational cohort study was to evaluate the association between admission hypothermia and neonatal outcomes in very low-birth weight (VLBW) infants multiple intensive care units (NICUs) China.Since January 1, 2018, a homogeneous cooperative research platform-Shandong Neonatal Network (SNN) has been established. platform collects clinical data prospective manner on preterm with birth weights (BWs) < 1500 g gestational ages (GAs) 34 weeks born...
Myocardial perfusion imaging with technetium-99m-labelled methoxyisobutyl isonitrile single photon emission computed tomography (99mTc-MIBI SPECT) has proven to be an important clinical procedure in assessing the severity of myocardial ischaemia. The uptake and clearance 99mTc-MIBI by myocardium is affected cell viability membrane integrity. Consequently, infectious diseases, such as myocarditis, may also affect inducing local inflammation necrosis. We compared other heart monitoring methods...
To explore the associations between higher antibiotic use rates (AURs) and adverse outcomes in very-low-birth-weight (VLBW) infants without culture-proven sepsis or necrotizing enterocolitis (NEC) a multicenter of China. A prospective cohort study was performed on VLBW admitted to 24 neonatal intensive care units from January 1, 2018, December 31, 2018. AUR calculated as calendar days therapy divided by total hospital days. The composite primary outcome defined mortality severe morbidity,...
There is a paucity of studies conducted in China on the outcomes all live-birth extremely premature infants (EPIs) and there no unified recommendation active treatment minimum gestational age field perinatal medicine China. We aimed to investigate current situation EPIs provide evidence for formulating reasonable recommendations.We established real-world ambispective cohort study live births delivery rooms with (GA) between 24+0 27+6 weeks from 2010 2019.Of 1163 included our study, 241...
Background Hypothermia is a common problem that associated with increased mortality and morbidity among preterm infants, especially in China. The objective of this study was to evaluate the efficacy targeted quality improvement (QI) project applied hypothermia prevention measures for very-low-birth-weight (VLBW) infants three tertiary neonatal intensive care units (NICUs) Problem Between January 2018 December 2018, we conducted prospective analysis found incidence AH 88.2% VLBW infants....
Abstract Background Admission hypothermia (AH, < 36.5℃) remains a major challenge for global neonatal survival, especially in developing countries. Baseline research shows nearly 89.3% of very low birth weight (VLBW, 1500 g) infants suffer from AH China. Therefore, prospective multicentric quality improvement (QI) initiative to reduce regional and improve outcomes among VLBW neonates was implemented. Methods The study used sequential Plan—Do—Study—Act (PDSA) approach. Clinical data were...
Abstract Background Hypertensive disorders of pregnancy (HDP) is the most common cause indicated preterm delivery, but impact prenatal steroid exposure on outcomes infants born to HDP mothers, who may be at risk for intrauterine hypoxia-ischemia, remains uncertain. The study objective evaluate mortality and morbidities in very (VPIs) exposed different course ANS. Methods This a prospective cohort comprising with < 32 weeks gestation women only from 1 Jan. 2019 31 Dec. 2021 within 40...
Abstract Background Published guidelines on decision-making and resuscitation of extremely preterm infants primarily focus high-income countries. For rapidly industrializing ones like China, there is a lack population-based data for informing prenatal management practice guidelines. Methods The Sino-northern Neonatal Network conducted prospective multi-centre cohort study between 1 January 2018 31 December 2021. Infants with gestational age (GA) 22 (postnatal in days = 0) 28 6) admitted to...
The aim of the present study was to analyze diagnostic value neutrophil gelatinase-associated lipocalin (NGAL) in renal injury asphyxiated preterm infants. In total, 48 cases infants, 45 premature infants and normal newborn were included study. Using ELISA we evaluated level urine NGAL, kidney molecule-1 (KIM-1), cystatin C (Cys-C) serum creatinine (Scr). We also calculated estimated glomerular filtration rate (eGFR). Our results showed that KIM-1 Cys-C levels group asphyxiant within 24 h...
Background At present, the relationship between thyrotropin (TSH) and free thyroxine (FT4) in relation to postmenstrual age (PMA) preterm infants is still unclear, there no reliable standard thyroid hormone reference ranges, resulting different diagnostic criteria for congenital hypothyroidism been used by newborn screening programs countries. Objectives To investigate TSH/FT4 PMA very (VPIs) born with gestational (GA) &lt;32 weeks derive function charts based on PMA. Methods A...
For initial respiratory management, continuous positive airway pressure (CPAP) is increasingly used for preterm infants, especially gestational age less than 32 weeks. However, neonatologists are concerned about the potential risks of CPAP support failure.To examine association between different modalities and outcomes infants at <32 weeks gestation across multiple neonatal intensive care units (NICU) in China.This study was carried out over a period 12 months 2018. Unadjusted relative (RR)...
Background Recently, with the rapid development of perinatal medical system and related life-saving techniques, both short-term long-term prognoses extremely preterm infants (EPIs) have improved significantly. In rapidly industrialising countries like China, survival rates EPIs notably increased due to swift socioeconomic development. However, there is still a reasonably lower positive response towards treatment than we expected, current situation withdrawing care an urgent task for...
Purpose: Significant antibiotic overuse due to prolonged duration has not draw enough attention in developing countries with high consumption. We aimed describe the current status of early very-low-birth-weight (VLBW) infants a large regional multicenter cohort China. Patients and Methods: Institution-based prospective study was conducted all VLBW admitted 16 Grade A tertiary hospitals between January 1, 2019 December 31, 2020. Early use defined as initiation within first 3 days life....
Early onset sepsis (EOS) remains a potentially fatal newborn condition, especially in very preterm infants. Data on the pathogen distribution and antibiotic susceptibility patterns of EOS among infants are scarce but essential for choice empirical administration. We sought to assess epidemiologic characteristics pathogens causing cohort China.This prospective, observational study included born at gestational age (GA) less than 32 weeks intensive care units (NICUs) China between January 1,...
Pulmonary hemorrhage (PH) in neonates is a life-threatening respiratory complication. We aimed to analyze the perinatal risk factors and morbidity with PH among very preterm infants large multicenter study.This was case-control study based on prospective cohort. Participants included 3,680 in-born gestational age at 24-32 weeks (birth weight <1,500 g) who were admitted between January 1, 2019, October 31, 2021. All divided into two groups, namely, no-PH ratio of 1:2 according following...
Objective: To assess the risk of necrotizing enterocolitis (NEC) and explore relationship between antibiotic overexposure disease occurrence in a large prospective birth cohort. Methods: Based on cohort, study collected hospitalization data very preterm infants (VPIs) having gestational age less than 32 weeks from January 1, 2018, to June 30, 2021 via China Northern Neonatal Network. Infants diagnosed with NEC ≥ stage II were included case group, each was matched for GA weight control group....