A5101497058- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Pancreatitis Pathology and Treatment
- Infectious Aortic and Vascular Conditions
- MicroRNA in disease regulation
- Advanced Glycation End Products research
- Phytochemistry and Biological Activities
- Nutrition and Health in Aging
- S100 Proteins and Annexins
- Abdominal vascular conditions and treatments
- Analytical Methods in Pharmaceuticals
- Acute Kidney Injury Research
- Adsorption and biosorption for pollutant removal
- Pharmacological Effects of Natural Compounds
- Lymphoma Diagnosis and Treatment
- Advanced Nanomaterials in Catalysis
- Nanomaterials for catalytic reactions
- Preterm Birth and Chorioamnionitis
- Dendrimers and Hyperbranched Polymers
- Analytical chemistry methods development
- Chronic Lymphocytic Leukemia Research
- Nanoplatforms for cancer theranostics
- Nuclear Receptors and Signaling
- Natural product bioactivities and synthesis
- Adipose Tissue and Metabolism
Shandong Provincial Hospital
2015-2023
Shandong First Medical University
2021-2023
Shandong University
2014-2023
Jinan Central Hospital
2021
Osteoarthritis, a chronic degenerative cartilage disease, is the leading cause of movement disorders among humans. Although specific pathogenesis and associated mechanisms remain unclear, oxidative stress-induced metabolic imbalance in chondrocytes plays crucial role occurrence development osteoarthritis. In this study, trimanganese tetroxide (Mn
Severe acute pancreatitis (SAP) is an extremely dangerous abdominal disorder which causes multiple complications and has a high mortality rate. Previous research suggested that high-mobility group box 1 (HMGB1) plays important role in the pathogenesis of SAP; however, mechanisms underlying this strong correlation remain unclear. In study, to further investigate whether HMGB1 acts as stimulating factor, Toll-like receptor 4 (TLR4) its major mediator development pancreatic injury during SAP,...
Determine the effect of AMPK activation and inhibition on development AAA (abdominal aortic aneurysm).AAA was induced in ApoE-/- mice by Ang II (Angiotensin II)-infusion. AICAR (5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside) used as activator Compound C inhibitor. We further investigate metformin, a widely anti-diabetic drug which could activate signal pathway, pathogenesis aneurysm.Phospho-AMPK level significantly decreased tissue compared with control aortas. reduced incidence,...
Chronic inflammation plays an essential role in the pathogenesis of abdominal aortic aneurysm (AAA), a progressive segmental dilation. Chemerin, multifunctional adipocytokine, is mainly generated liver and adipose tissue. The combination chemerin chemokine-like receptor 1 (CMKLR1) has been demonstrated to promote progression atherosclerosis, arthritis diseases, Crohn’s disease. However, chemerin-9 acts as analog exert anti-inflammatory effect by binding CMKLR1. Here, we first that AAA...
The aim of the present study was to analyze diagnostic value neutrophil gelatinase-associated lipocalin (NGAL) in renal injury asphyxiated preterm infants. In total, 48 cases infants, 45 premature infants and normal newborn were included study. Using ELISA we evaluated level urine NGAL, kidney molecule-1 (KIM-1), cystatin C (Cys-C) serum creatinine (Scr). We also calculated estimated glomerular filtration rate (eGFR). Our results showed that KIM-1 Cys-C levels group asphyxiant within 24 h...
<b><i>Aims:</i></b> Aortic mural inflammatory damage takes a vital part in abdominal aortic aneurysm (AAA). Recently, ulinastatin (UTI) has attracted attention for its anti-inflammatory function. Our study aimed to evaluate potential influences of UTI on experimental AAA. <b><i>Methods:</i></b> A mouse model AAA was induced by infusion porcine pancreatic elastase (PPE) into the aorta. Mice were treated with (50,000 U/kg/day i.p.) beginning...
The aim of this study was to investigate the anti-inflammatory activity essential oil from Solanum lyratum Thunb. by silico study. To regard, extracted hydrodistillation. 25 compounds were identified GC-MS. Through virtual screening, molecular docking and dynamics simulation compounds, with good effect on COX-2 obtained. According drug-like principle prediction ADEMT properties, six Spathulenol, Cedrol, Juniper camphor, Santalol, Nootkatone...
Traumatic brain injury (TBI) is a worldwide public health concern without major therapeutic breakthroughs over the past decades. Developing effective treatment options and improving prognosis of TBI depends on better understanding mechanisms underlying TBI. This study performed comprehensive analysis 15 RNA expression datasets rat TBIs from GEO database. By integrating results various analyses, this investigated biological processes, pathways, cell types associated with explored activity...
The novel coronavirus, 2019-nCoV, has led to a major pandemic in 2020 and is responsible for more than 2.9 million officially recorded deaths worldwide. As well as synthetic anti-viral drugs, there also need explore natural herbal remedies. Traditional Chinese Medicines (TCMs) system been used thousands of years the prevention, diagnosis, treatment several chronic diseases. In this paper, we performed an silico molecular docking interaction analysis TCMs against SARS-CoV-2 receptor...