A5102014083- Immunodeficiency and Autoimmune Disorders
- Adipose Tissue and Metabolism
- Inflammatory Bowel Disease
- TGF-β signaling in diseases
- Cytokine Signaling Pathways and Interactions
- RNA Research and Splicing
- Diet and metabolism studies
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- Apelin-related biomedical research
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Biological and pharmacological studies of plants
- Antimicrobial Peptides and Activities
- Diphtheria, Corynebacterium, and Tetanus
- Healthcare and Environmental Waste Management
- Pancreatic and Hepatic Oncology Research
- Cardiac Fibrosis and Remodeling
- Hepatocellular Carcinoma Treatment and Prognosis
- Psoriasis: Treatment and Pathogenesis
- Vibrio bacteria research studies
- Urinary and Genital Oncology Studies
- Cancer-related gene regulation
Qilu Hospital of Shandong University
2020-2024
Zhejiang Chinese Medical University
2018-2023
Shanghai Institute of Materia Medica
2022
Chinese Academy of Sciences
2022
Shanxi University
2020
Shandong University
2016-2020
Shandong Provincial Hospital
2016
Qingdao University
2015
Affiliated Hospital of Qingdao University
2015
Wuhan University
2013-2014
Abstract Background Diabetes and obesity are associated with muscle atrophy that reduces life quality lacks effective treatment. Mesenchymal stromal cell (MSC)‐based therapy can ameliorate high fat‐diet (HFD) immobilization (IM)‐induced in mice. However, the effect of MSCs on type 2 diabetes mellitus (T2DM) potential mechanism is unclear. Here, we evaluated efficacy explored molecular mechanisms human umbilical cord (hucMSCs) hucMSC‐derived exosomes (MSC‐EXO) diabetes‐ obesity‐induced...
Background. More and more studies focus on the relationship between gastrointestinal microbiome type 2 diabetes, but few of them have actually explored enterotypes diabetes. Materials Methods. We enrolled 134 patients with diabetes 37 nondiabetic controls. The anthropometric clinical indices each subject were measured. Fecal samples also collected processed for 16S rDNA sequencing. Multiple logistic regression analysis was used to determine associations linear explore lipopolysaccharide...
An older age contributes to the development of bladder cancer. However, relationship between advanced at diagnosis and prognosis cancer has been few reported. This study aimed determine effect on survival in with different subgroups.117,275 patients cancer, identified from Surveillance, Epidemiology, End Results database during 2004-2015 America, were divided into 4 groups (≤54, 55 64, 65 74, ≥75 years). Multivariable Cox proportional-hazards model competing risk conducted according groups....
Puerarin has shown unique pharmacological effects on myocardial ischemia (MI). Changing the crystal form is an effective approach to improve cardioprotective of puerarin. However, mechanisms new puerarin are unclear. In this study, electrocardiogram, echocardiography, cardiac marker enzymatic activity, oxidative stress indices, and histology analysis tissues were performed evaluate Moreover, serum tissue metabolomics based nuclear magnetic resonance (NMR) used investigate potential mechanism...
Abstract Diabetic wounds have become a global healthcare burden owing to impaired angiogenesis and persistent infections. Extracellular vesicles (EVs) can improve diabetic wounds, though their targeting ability is limited. In this study, we investigated the performance of novel hydrogel dressing comprised gelatin methacryloyl, glycoengineered EVs, polylysine in treating infected wounds. High‐throughput single‐cell RNA sequencing (scRNA‐seq) immunofluorescence staining revealed that...
Abstract Background: To study the occurrence and prognosis of acute respiratory distress syndrome (ARDS) using single nucleotide polymorphisms (SNPs) TNF-α rs1800629, IL-6 rs1800796, MyD88 rs7744 loci in TLR4/NF-κB pathway. Methods: Genotypes were analyzed for loci. Plasma levels mRNA expression peripheral blood mononuclear cells (PBMCs) 300 ARDS patients non-ARDS (control group) examined. The followed up 60 days, outcome was recorded. Results: rs1800629 locus A allele rs1800796 G found to...
Both the biosynthesis and array of bioactive medicinal compounds in plants can be influenced by interactions with endophytic exogenous fungi. However, composition fungal communities associated many is unknown, mechanism which these fungi stimulate secondary metabolism host unclear. In this study, we conducted a correlative analysis between dendrobine biomass accumulation Dendrobium nobile across five Chinese habitats: wild Danxia rock, greenhouse-associated large stone, broken coarse...
AIM:To determine whether the human giant larvae homolog 1 gene (Hugl-1/Llg1/Lgl1) exerts tumor suppressor effects in esophageal cancer. METHODS:We constructed a Hugl-1 expression plasmid, pEZ-M29-Hugl1, for transfection.We transfected pEZ-M29-Hugl1 plasmid into Eca109 cancer cell lines with Lipofectamine 2000 to overexpress Hugl-1.Real-time reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting were performed of on expression.In vitro proliferation apoptosis examined...
Objective: To examine the association between brain natriuretic peptide (BNP) gene single nucleotide polymorphisms (SNPs) and chronic obstructive pulmonary disease (COPD) COPD with hypertension (PH) to analyze its mechanism. Methods: The genotypes of BNP at rs198389, rs6668352, rs198388 loci in 339 patients (205 COPD/PH− group 134 COPD/PH+ group) 125 healthy subjects were detected by PCR/Sanger sequencing. serum levels BNP, fibrinogen (Fbg), Apelin measured all ELISA. Results: rs198389 locus...
Tetrahydroxystilbene glucoside (TSG) is extracted from a famous Chinese herbal medicine which widely used as an antiaging agent in history. Lots of studies gave evidence that TSG exhibited benefits to brain, like improvement learning and memory synaptic plasticity. Moreover, the polyphenolic structure enables its capability prevent cerebral ischemia/reperfusion injury (IRI) by reducing apoptosis ROS/RNS generation. Due antioxidant profile, had been demonstrated alleviate cardiac toxicity...
Transforming growth factor (TGF)-β1 contributed to angiotensin II (Ang II)-mediated collagen accumulation after myocardial infarction (MI). The present study aimed investigate the association of genetic variant TGF-β1 gene with risk MI. recruited a total 530 MI patients and 651 healthy controls. genomic DNA was extracted subjected into polymerase chain reaction (PCR) Sanger sequencing. indicated that -913G/C polymorphism associated increased for under co-dominant, dominant allelic models....
Aim: Patients with type 2 diabetes (T2DM) often suffer from muscle cramps of varying severity. Studies have shown that cramp is closely related to local microcirculation perfusion disorders. Diabetic retinopathy can not only reflect the in eye but also systemic patients diabetes. The aims this study were investigate relationship between and diabetic Methods: A total 150 adult enrolled administered a questionnaire on cramping, along visual analogue scale for pain. (DR) was determined by using...
Objective To study the effects of edaravone (ED) on expression lung transforming growth factor-β1 (TGF-β1) in dogs with cardio-pulmonary bypass (CPB).Methods Thirty adult were randomly divided into three groups (n =10):group C receiving normal saline during CPB,group E1 ED before CPB,and group E2 CPB.Lung superoxide dismutase (SOD) activity,malondialdehyde (MDA) level,and TGF-β1 determined CPB (T0),30 min (T1),15 rmin after (T2),30 (T3),60 (T4) all dogs.The histological pathology was...