A5050492383- Cytomegalovirus and herpesvirus research
- Autophagy in Disease and Therapy
- Ocular Diseases and Behçet’s Syndrome
- Toxoplasma gondii Research Studies
- Retinal Diseases and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Herpesvirus Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Extracellular vesicles in disease
- Organ Transplantation Techniques and Outcomes
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- interferon and immune responses
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Neonatal Health and Biochemistry
- Pharmacological Effects of Natural Compounds
- HIV Research and Treatment
- Protein Degradation and Inhibitors
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2025
Key Laboratory of Guangdong Province
2025
Xi'an Honghui Hospital
2025
Xi'an Jiaotong University
2025
Augusta University
2013-2024
Charlie Norwood VA Medical Center
2017-2024
Jiangxi University of Technology
2024
West China Hospital of Sichuan University
2024
Nanjing Drum Tower Hospital
2024
Immunotherapy with T cells expressing the chimeric antigen receptor (CAR) specific for CD19 (CD19.CAR-Ts) is a very effective treatment in B cell lymphoid malignancies. However, aplasia and cytokine release syndrome (CRS) secondary to infusion of CD19.CAR-Ts remain significant drawbacks. The inclusion safety switches into vector encoding CAR seen as safest method terminate effects case severe toxicities or after achieving long-term sustained remissions. By contrast, complete elimination when...
Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the underlying mechanism and its pathogenic role remain elusive. We show that was inhibited DKD models human kidneys. Ablation autophagy-related gene 7 (Atg7) from proximal tubules led to deficiency worse renal hypertrophy, tubular damage, inflammation, fibrosis, albuminuria mice, indicating a protective DKD. Autophagy impairment associated with downregulation unc-51-like autophagy-activating kinase 1 (ULK1),...
Renal interstitial fibrosis is a common pathological feature of chronic kidney disease that may involve changes metabolism in cells. In the present study, we first showed blockade glycolysis with either dichloroacetate (DCA) or shikonin to target different glycolytic enzymes reduced renal mouse model unilateral ureteral obstruction (UUO). Both inhibitors evidently suppressed induction fibronectin and collagen type I obstructed kidneys, DCA also showing inhibitory effects on IV α-smooth...
Prostate cancer is the most common in men. The molecular mechanisms leading to its development are poorly understood. Maspin a tumor-suppressing serpin expressed normal breast and prostate epithelium. We have found that expression of maspin carcinoma-derived epithelial cells differentially regulated at transcriptional level. identified two different kinds cis elements, Ets hormonal responsive element (HRE), promoter. active regulating but inactive tumor cells. HRE site negative both cell...
Severe sepsis involves massive activation of the innate immune system and leads to high mortality. Previous studies have demonstrated that various types TLRs mediate a systemic inflammatory response contribute organ injury mortality in animal models severe sepsis. However, downstream mechanisms responsible for TLR-mediated septic are poorly understood. In this article, we show TLR2, TLR3, TLR4 markedly enhanced complement factor B (cfB) synthesis release by macrophages cardiac cells....
Mechanical stress has detrimental effects on cartilaginous endplate chondrocytes due to apoptosis in vivo and vitro. In this study, we investigated the possible signaling pathways induced by mechanical cultured rat cervical chondrocytes. Static load significantly reduced cell viability a time- load-dependent manner, as demonstrated Cell Counting Kit-8 (CCK-8) assay. Chondrocyte was confirmed annexin V/propidium iodide (PI) staining terminal deoxynucleotidyl transferase dUTP nick-end labeling...
Congenital cytomegalovirus (cCMV) infection is the leading infectious cause of neurodevelopmental disorders. However, neuropathogenesis remains largely elusive due to a lack informative animal models. In this study, we developed congenital murine CMV (cMCMV) mouse model with high survival rate and long period that allowed long-term follow-up study This involves in utero intracranial injection mimics many reported clinical manifestations cCMV infants, including growth restriction, hearing...
Macroautophagy/autophagy contributes to maladaptive kidney repair by inducing pro-fibrotic factors such as FGF2 (fibroblast growth factor 2), but the underlying mechanism remains elusive. Here, we show that EGR1 (early response 1) was induced in injured proximal tubules after ischemic acute injury (AKI) and this induction suppressed autophagy deficiency inducible, renal tubule-specific atg7 (autophagy related 7) knockout (iRT-atg7 KO) mice. In cultured tubular cells, TGFB1 (transforming beta...
The molecular basis of renal interstitial fibrosis, a major pathological feature progressive kidney diseases, remains poorly understood. Autophagy has been implicated in but whether it promotes or inhibits fibrosis controversial. Moreover, is unclear how autophagy activated and sustained fibrosis. present study was designed to address these questions using the vivo mouse model unilateral ureteral obstruction vitro hypoxia tubular cells. Both models showed activation hypoxia-inducible...
Exosomes (Exos) generated from bone mesenchymal stem cells (BMSCs) are elucidated to enhance cutaneous wound healing in mice models of diabetes mellitus (DM). While underlying mechanisms remain unknown.
Age-related macular degeneration (AMD) is a chronic retinal disease that significantly influences the vision of elderly.