A5100445576- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiovascular Health and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiac tumors and thrombi
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Acute Ischemic Stroke Management
- Viral Infections and Immunology Research
- Medical Imaging Techniques and Applications
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Obstructive Sleep Apnea Research
- Radiomics and Machine Learning in Medical Imaging
Huazhong University of Science and Technology
2006-2025
Dalian Medical University
2025
Peking University
2020-2024
China Medical University
2020-2024
Shanxi Medical University
2022-2024
First Hospital of China Medical University
2024
Peking University People's Hospital
2024
Xinjiang Medical University
2024
People's Hospital of Xinjiang Uygur Autonomous Region
2024
Central South University
2024
<title>Abstract</title> Background Mesenchymal stem/stromal cell (MSCs) therapy represents a potential therapeutic tool to treat RA, but loss of secretory property post delivery restricted clinical application. It has been verified that endoplasmic reticulum stress (ERS)-MSCs exhibited better inhibition on rheumatoid arthritis (RA) T follicular helper cells (Tfh) via cyclooxygenase-2 (COX2)/prostaglandin E2 (PGE2) activation with unknown molecular mechanism, particulary the overall outcome...
Cyclic adenosine monophosphate (cAMP) plays a major role in normal and pathologic signaling the heart. Phosphodiesterase 4 (PDE4) is PDE degrading cAMP There are inconsistencies concerning roles of PDE4 isoforms 4B 4D regulation cardiac function. Cardiac PDE4B overexpression beneficial remodeling heart failure (HF), however, effect PDE4D inhibitor HF remains unclear. We generated global conditional cardiac-specific heterozygous knockout mice adeno-associated virus serotype 9-PDE4D to...
Arrhythmogenic cardiomyopathy (ACM) is an inherited disorder with variable genetic etiologies. Here, we focused on understanding the precise molecular pathology of a single clinical variant in DSP, gene encoding desmoplakin. We initially identified potentially novel missense desmoplakin (p.R451G) patient diagnosed biventricular ACM. An extensive single-family ACM cohort was assembled, revealing pattern coinheritance for R451G and phenotype. vitro model system using patient-derived induced...
Abstract Objective As an extracellular vesicle, exosomes can release from virus‐infected cells containing various viral or host cellular elements and could stimulate recipient's response. Enterovirus 71 (EV71), a single‐strand positive‐sense RNA virus, is known to cause hand, foot, mouth disease (HFMD) in children bring about severe clinical diseases. Methods Separated the human oral epithelial (OE cells) normal buccal mucosa through enzyme digestion. Performed comprehensive miRNA profiling...
Background It is unclear whether short‐term blood pressure variability associated with renal outcomes in patients chronic kidney disease. Methods and Results This study analyzed data from participants the C‐ STRIDE (Chinese Cohort Study of Chronic Kidney Disease) who had disease stages 1 to 4. Short‐term was measured by calculating weighted SD (w‐ ) systolic ( SBP ). Renal were defined as dialysis initiation and/or transplantation. Risk factors w‐ evaluated linear regression. Associations...
The 4-dimensional automated left atrial quantification (4D Auto LAQ) tool is a new software for analysis of the structure and function atrium (LA). This study aimed to evaluate relationship between LA strain (LAS) as measured by 4D LAQ echocardiography thromboembolism risk in patients with non-valvular fibrillation (NVAF).Eight-five NVAF were recruited from cardiovascular center our hospital, including 39 at high 46 low thromboembolism. participants assessed routine echocardiography; images...
To explore the associations between higher antibiotic use rates (AURs) and adverse outcomes in very-low-birth-weight (VLBW) infants without culture-proven sepsis or necrotizing enterocolitis (NEC) a multicenter of China. A prospective cohort study was performed on VLBW admitted to 24 neonatal intensive care units from January 1, 2018, December 31, 2018. AUR calculated as calendar days therapy divided by total hospital days. The composite primary outcome defined mortality severe morbidity,...
The cardiomyopathies are a group of heart muscle diseases which can be inherited (familial). Identifying potential disease-related proteins is important to understand mechanisms cardiomyopathies. Experimental identification cardiomyophthies costly and labour-intensive. In contrast, bioinformatics approach has competitive advantage over experimental method. Based on "guilt by association" analysis, we prioritized candidate involving in human We first built weighted cardiomyopathy-specific...
Abstract Purpose In this retrospective study, we evaluated the treatment patterns and survival after positron emission tomography-computed tomography (PET/CT)-guided local consolidation therapy (LCT) for oligometastatic non-small cell lung cancer (NSCLC). Methods We reviewed medical records of Chinese patients with stage IV (≤ 5 metastases) who had undergone PET/CT were eligible systemic at two centers between May 2005 August 2019. Propensity score matching (1:1) was used to reduce selection...
This trial targeted to analyze the effects of different doses tirofiban combined with dual antiplatelet drugs on platelet indices, vascular endothelial function, and major adverse cardiovascular events (MACE) in patients acute ST-segment elevated myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). A total 180 STEMI who underwent PCI were divided into Group A, B, C (60 cases per group). was given conventional medication, Groups B a standard dose (10 μg/kg) high...
Type 2 diabetes mellitus is a metabolic disease that affects multiple target organs. Current data on right ventricular damage in type diabetes, especially prediabetes, are limited. Due to the anatomical characteristics of ventricle, assessment ventricle by conventional echocardiography difficult, whereas ultrasound two-dimensional speckle tracking can provide information myocardial systolic function motion speckles, which sensitively reflect mechanical changes.To assess effect prediabetes...
Several studies using two-dimensional speckle tracking echocardiography (2D-STE) have confirmed the presence of left ventricular (LV) systolic dysfunction in patients with diabetes mellitus (DM), but there is a paucity on whether three-dimensional (3D)-STE superior to 2D-STE. The aim this study was evaluate clinical value 3D-STE assessing subclinical LV prediabetic and diabetic preserved ejection fraction (LVEF) investigate independent risk factors for medical disorder.This included 40...
Primary mediastinal liposarcomas are extremely rare. The current study reports the case of a 63-year-old man presenting with primary liposarcoma arising from posterior mediastinum. patient reported 6‑month history chest pain increasing dyspnea for 2 months. Enhanced computed tomography revealed 10x16‑cm mass in Other physical examinations were normal. Radical resection was performed under agreement patient. Subsequent pathological analysis indicated liposarcoma. recovered and successfully...
Pulmonary arterial hypertension (PAH) is a severe disease characterized by elevated pulmonary pressure and vascular resistance, resulting in right ventricular failure death. Compelling evidence has suggested the roles of microRNAs (miRNAs/miRs) PAH. The present study investigated possible effects miR‑let‑7d on PAH through autophagy‑related 16‑like 1 (ATG16L1). Initially, serum levels let‑7d patients were detected. Rats then treated with monocrotaline to induce rat model PAH, after which...
The treatment of advanced lung cancer has been revolutionized by immune checkpoint inhibitors (ICIs) in recent years, largely driven programmed cell death-1 (PD-1) inhibitors. However, patients with who are treated PD-1 prone to immune-related adverse events (irAEs), especially cardiac events. Noninvasive myocardial work is a novel technique used assess left ventricular (LV) function, which can effectively predict damage. Here, noninvasive was evaluate changes LV systolic function during...
BACKGROUND: Patent foramen ovale (PFO) and obstructive sleep apnea (OSA) are independent risk factors for young conscious stroke which may also be concomitant symptoms with it.But there is no sufficient attention on these phenomena.OBJECTIVE: To investigate the relationship between PFO, OSA stroke, to look proper treatment.METHODS: Three patients were reported, each of them was combined PFO OSA.All diagnosed as wake-up (WUS).Contrast-enhanced transcranial doppler ultrasound (c-TCD)...
Systemic lupus erythematosus (SLE) is associated with a variety of cardiovascular diseases, even in the early stage disease development. The purpose this study was to quantitatively evaluate left ventricular (LV) systolic function patients SLE using novel non-invasive pressure-strain loop (PSL) technique.This prospective case-control included 132 and 99 normal controls, all whom underwent traditional transthoracic echocardiography. LV myocardial work evaluated PSL technique based on speckle...
Objective: To investigate the clinical characteristics and treatment methods of rhabdomyosarcoma in children efficacy methods.
 Methods: The data 30 with who were admitted to our hospital from August 2013 2017 retrospectively analyzed. summarized, curative effect prognosis evaluated.
 Results: Among all (N=30), there 20 males 10 females, a median age 3.5 years. As primary site, 13 cases head neck, 11 trunk, three urogenital system limbs. There 25 embryonic type, 4 alveolar type one...