A5050351896- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Crystallography and molecular interactions
- Peptidase Inhibition and Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Cardiac tumors and thrombi
- Osteoarthritis Treatment and Mechanisms
- Adrenal and Paraganglionic Tumors
- Occupational and environmental lung diseases
- Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Respiratory Support and Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Oral and Maxillofacial Pathology
The First People's Hospital of Changde
2008-2025
Central South University
2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
National Institute for Occupational Health and Poison Control
2023-2024
Lishui Central Hospital
2009-2024
Second Military Medical University
2024
Anshan Hospital
2021-2023
Nantong University
2014-2023
Second People's Hospital of NanTong
2023
The exact pathogenic mechanism of knee osteoarthritis (OA) is still unknown. With the exception clinical treatment to alleviate symptoms, or total replacement, there currently no effective method. Consequently, an in-depth etiological and epidemiological study OA can provide clues for diagnosis, scientific research, will ultimately have a beneficial effect on public health. A cross-sectional community in rural village Gaoyou was conducted 3428 Chinese adults (aged ≥ 40 years). Subjects...
The aim of this study was to investigate the prognostic value lymphocyte-to-monocyte ratio (LMR) in patients undergoing hepatectomy and compare it established biomarkers including neutrophil-to-lymphocyte (NLR) platelet-to-lymphocyte (PLR). Medical records were retrospectively analyzed for 652 HCC at Affiliated Tumor Hospital Guangxi University First People's Changde between April 2004 2012. correlation LMR clinical variables Kaplan-Meier log-rank survival analysis then multivariate Cox...
Predicting the recurrence risk of lung cancer is critical for appropriate adjuvant therapy patients after surgical resection. However, traditional circulating tumor cell (CTC) detection or next generation sequencing-based methods are usually expensive and time-inefficient, which urges need more efficient computational models. In this study, we have established a convolutional neural network (CNN) framework called DeepLRHE to predict through analyzing histopathology images. consists few steps...
To evaluate the feasibility of multi-parameters combined simplified intensity-modulated radiation therapy (sIMRT) planning in thoracic tumors and provide guidance for clinical practice. A total 34 patients with who underwent radiotherapy during 2019 to 2020 our hospital were retrospectively analyzed. The same experienced medical physicist designed sIMRT planning. limited maximum number segments per beam-field, minimum segment area, monitor units (MU), remaining consistent conventional...
3-Substituted oxindoles as electrophilic partners: An unprecedented method for the construction of hydroxylated 3-substituted in high yields and excellent enantioselectivities through stereoablative hydroxylation 3-halooxindoles with an organocatalyst has been developed. This process not only differs from common convention using nucleophiles, but also provides a viable entry to optically active 3-hydroxy-2-oxindoles (see scheme).
In this study, the expression of neural precursor cell expressed developmentally downregulated 9 (NEDD9) in benign and malignant gastric tissues was investigated, significance NEDD9 cancer prognosis explored. Immunohistochemistry used to detect cancer, nontumor gastric, normal tissues. The relationship between clinicopathologic factors examined using Mann–Whitney U test. two tumor node metastasis (TNM) stage patients were analyzed by Spearman rank correlation analysis. Kaplan–Meier method...
Recently, evidence has emerged that palliative gastrectomy in patients with stage IV gastric cancer may offer some survival benefits. However, the decision whether to perform primary tumor surgery remains challenging for surgeons, and investigations into models are predictive of prognosis scarce. Current study aimed develop validate prognostic nomograms metastatic adenocarcinoma treated gastrectomy. The development dataset comprised 1186 from Surveillance, Epidemiology, End Results Program...
Background: To investigate the prognostic significance of cumulative score based on preoperative fibrinogen and pre-albumin (FP score) in patients with gastric cancer after radical gastrectomy. Methods: Baseline characteristics, levels were retrospectively reviewed who underwent The optimal cut-off values for defined as 4.0 g/L 230.0 mg/L, respectively. Patients elevated (≥ g/L) decreased (< mg/L) allocated an FP 2, those only one these two abnormalities assigned a 1, neither 0. value was...
This study aimed to investigate the effect of palliative gastrectomy on survival in stage IV gastric cancer.Patients diagnosed with cancer between 2010 and 2016 were selected from Surveillance, Epidemiology, End Results (SEER) database. Survival curves estimated by Kaplan-Meier method before after propensity score matching (PSM). Univariate multivariate Cox analyses performed evaluate risk factors for patients who underwent gastrectomy.We examined 6,529 cancer, which 625 gastrectomy. Using a...
Survival times differ among patients with advanced gastric carcinoma. A precise and universal prognostic evaluation strategy has not yet been established. The current study aimed to construct a scoring model for mortality risk stratification in carcinoma.Patients carcinoma from two hospitals (development validation cohort) were included. Cox proportional hazards regression analysis was conducted identify independent factors survival. nomogram developed using R statistics validated both...
Primary mediastinal liposarcomas are extremely rare. The current study reports the case of a 63-year-old man presenting with primary liposarcoma arising from posterior mediastinum. patient reported 6‑month history chest pain increasing dyspnea for 2 months. Enhanced computed tomography revealed 10x16‑cm mass in Other physical examinations were normal. Radical resection was performed under agreement patient. Subsequent pathological analysis indicated liposarcoma. recovered and successfully...
This study aimed to identify prognostic factors for patients with distant lymph node-involved gastric cancer (GC) using a machine learning algorithm, method that offers considerable advantages and new prospects high-dimensional biomedical data exploration.This employed 79 features of clinical pathology, laboratory tests, therapeutic details from 289 GC whose lymphadenopathy was presented as the first episode recurrence or metastasis. Outcomes were measured any-cause death events survival...
Gastric cancer liver metastasis (GCLM) patients usually accompany by abnormal serum function tests (LFTs) more or less; however, the prognostic value of LFTs is not fully understood. This study aimed to develop a chemistry score (LCS) based on and incorporate it into prognosis determination for GCLM who received palliative chemotherapy.Data were derived from hospitalized in two general hospitals China. LCS was generated results LASSO regression. Cutoff determined restricted cubic spline. The...
Tumor metastasis is a common event in patients with gastric cancer (GC) who previously underwent curative gastrectomy. It meaningful to employ high-volume clinical data for predicting the survival of metastatic GC patients. We aim establish an improved machine learning (ML) classifier if patient would die within 12 months. Eligible were enrolled from Chinese cohort, and complete detailed information medical records was extracted generate high-dimensional dataset. Appropriate feature...
ObjectivesGiven the modest efficacy of docetaxel in advanced non-small cell lung cancer (NSCLC), this study assesses therapeutic potential and safety profile anlotinib combination with compared to monotherapy as a second-line therapy for patients NSCLC.Materials MethodsIn phase II study, NSCLC experiencing failure first-line platinum-based regimens were randomized 1:1 ratio receive either plus or alone. Primary endpoint was progression-free survival (PFS), overall (OS), objective response...
Epithelioid angiosarcoma arising in schwannoma is an extremely rare mesenchymal tumor that accounts for only 1 to 2% of all sarcomas. This type occurs parts the body, most often skin and soft tissues rarely mediastinum. The present study describes case asymptomatic, 58-year-old male who presented with epithelioid posterior mediastinum during a physical examination. Enhanced computed tomography chest revealed 3.5 × 3.1-cm mass Thoracoscopic mediastinal resection was performed under general...
Abstract Background To evaluate whether the addition of taxanes to platinum and fluoropyrimidines in adjuvant chemotherapy would result longer survival than plus gastric cancer patients who received D2 gastrectomy. Methods Data with adenocarcinoma gastrectomy or taxanes, was retrospectively collected analyzed. 1:1 Propensity score matching analysis used balance baseline characteristics between two groups. Survival curves were estimated using Kaplan-Meier method, differences compared log-rank...
Background Tacrolimus (Tac) is commonly used for postoperative immunosuppressive therapy in transplant patients. However, problems, example, low bioavailability and unstable plasma concentration, persist a long time, Studies have reported that the deoxyschizandrin could effectively improve these but pharmacokinetic parameters (PKs) of Tac combined with are still unknown. Method In this study, an UHPLC-MS/MS method has been established simultaneous quantitation deoxyschizandrin. The PKs...
Abstract Colon cancer (CC) has a poor 5-year survival rate though the treatment techniques and strategies have been improved. Succinylation long noncoding RNAs (lncRNAs) prognostic value for CC patients. We analyzed obtained succinylation-related lncRNA by co-expression in CC. A novel model was developed univariate Least absolute shrinkage selection operator (Lasso) regression analysis we used principal component (PCA), functional enrichment annotation, tumor immune environment, drug...