A5112565755- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Renal and Vascular Pathologies
- Lung Cancer Treatments and Mutations
- Pediatric Urology and Nephrology Studies
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Renal and related cancers
- PI3K/AKT/mTOR signaling in cancer
- Gastric Cancer Management and Outcomes
- Chronic Kidney Disease and Diabetes
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Cervical Cancer and HPV Research
- Colorectal Cancer Screening and Detection
- Multiple and Secondary Primary Cancers
- Genetic Associations and Epidemiology
- Tuberous Sclerosis Complex Research
- Ureteral procedures and complications
- Polyamine Metabolism and Applications
- Cancer Risks and Factors
The First People's Hospital of Changde
2022-2025
Weatherford College
2025
Central South University
2024-2025
Hainan Medical College Hospital
2021-2024
Sun Yat-sen Memorial Hospital
2011-2022
Sun Yat-sen University
2008-2022
Bridge University
2021
Fifth Affiliated Hospital of Sun Yat-sen University
2021
Hainan General Hospital
2016-2020
First Affiliated Hospital of Zhengzhou University
2020
BackgroundAlterations in the brain cortical structures of patients with chronic kidney disease (CKD) have been reported; however, cause has not determined yet. Herein, we used Mendelian randomization (MR) to reveal causal effect damage on structure.MethodsGenome-wide association studies summary data estimated glomerular filtration rate (eGFR) 480,698 participants from CKDGen Consortium were identify genetically predicted eGFR. Data 567,460 individuals assess CKD; 302,687 UK Biobank evaluate...
To evaluate the feasibility of multi-parameters combined simplified intensity-modulated radiation therapy (sIMRT) planning in thoracic tumors and provide guidance for clinical practice. A total 34 patients with who underwent radiotherapy during 2019 to 2020 our hospital were retrospectively analyzed. The same experienced medical physicist designed sIMRT planning. limited maximum number segments per beam-field, minimum segment area, monitor units (MU), remaining consistent conventional...
This study evaluates the dosimetric benefits of off-line adaptive radiotherapy (ART) planning during for locally advanced cervical cancer. Forty-four patients in our hospital were included. The monitored by cone-beam CT (CBCT), and secondary scanning was performed timely. ART2 based on tumor regression compared with initial (ART1). mean time thirteen fractions, gross volume (GTV) decreased 23.3%. ART1 planning, significantly reduced dose PGTV (defined as GTV 5 mm expansion all directions)-D...
To evaluate the clinical diagnostic validity of carbon nanoparticle suspension (CNS) in sentinel lymph node biopsy (SLNB) for assessing lymphatic spread early-stage cervical cancer.A prospective study.356 cases.We enrolled 356 stage Ia2-IIa2 cancer patients to undergo SLNB using CNS, followed by systematic pelvic lymphadenectomy. All specimens were assessed conventional histopathologic ± pathologic ultrastaging analyses.Sentinel detection rate (DR), and various related factors analysed.CNS...
Purpose: The aim of this study was to review the clinicopathologic characteristics, treatments, and outcomes patients with primary large cell neuroendocrine carcinoma bladder (LCNEC). Patients Methods: We report one patient diagnosed pure LCNEC in Sun Yat-sen Memorial Hospital. In addition, we performed a systematic literature review, April 2020, on case series bladder. treatments rare disease were analyzed. Results: A total 39 included our analysis (1 from institution 38 cases literature)....
Follicular helper T cells (Tfh) represent a distinct subset of CD4+ specialized in providing help to B lymphocytes. Studies have indicated that Tfh circulating blood can act as prognostic marker for diseases. In the current study, we investigated percentages (CTfh) Crohn's disease (CD) and CD-associated colorectal cancer (CRC). CTfh it subtypes were determined by measuring CD3, CD4, CXCR5, CXCR3, CCR6 using flow cytometry 32 healthy controls 78 CD patients, which included 16 CRC. Data showed...
Primary pulmonary enteric adenocarcinoma (PEAC) is a rare invasive clinically similar to metastatic colorectal (MCRC). Although many studies have addressed the differential diagnosis of PEAC, few described treatment especially using immunotherapy. This report describes 61-year-old man who presented initially with pain in ribs. Pathological analysis biopsy samples shows malignant tumors right pleura, and next-generation sequencing 26 genes showed KRAS gene mutation. Positron emission...
Abstract Background: METex14 mutations was reported in 3~4% of NSCLC patients and became a new target the treatment NSCLC. SCC244 is highly selective potent oral MET inhibitor. This first report data from an ongoing single-arm phase II study with (GLORY study). Methods: GLORY open label, international, multi-center, to evaluate efficacy safety locally advanced or metastatic harboring which confirmed by central laboratory. The enrolled have either failed one two prior lines systemic therapies...
To create and evaluate the effectiveness of an in vitro training model for laparoscopic urethrovesical anastomosis.Chicken posterior trunks porcine colons were used to construct model, which was later compared with chicken skin model. The trunk a simulate human pelvis, 3-mm cloacal stump urethral stump. A 15-cm segment colon 1-cm orifice bladder or neobladder. An imitation anastomosis performed instruments box. simulated neck anastomosed six interrupted stitches. Forty urologic residents...
Background: Previous studies have suggested that patients with lung adenocarcinoma (LUAD) will significantly benefit from epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI). However, many LUAD develop resistance to EGFR-TKI. Thus, our study aims models predict EGFR-TKI and the prognosis. Methods: Two Gene Expression Omnibus (GEO) datasets (GSE31625 GSE34228) were used as discovery find common differentially expressed genes (DEGs) in resistant profiles. The association of...
Advanced non-small cell lung cancer (NSCLC) with MET amplification primarily relies on inhibitors for treatment, but once resistance occurs, the available treatment options are limited and prognosis is typically poor. A 57-year-old man advanced NSCLC C-MET was initially treated crizotinib developed progressive disease. After antirotinib he achieved a partial response year. Genetic testing showed high PD-L1 expression, pembrolizumab chemotherapy 3 months, response. Maintenance therapy local...
A growing body of evidence indicates that patients with colorectal serrated lesions, especially advanced lesions (ASLs), are at risk subsequent malignancy. This study aimed to analyze the clinicopathological features ASLs and association between synchronous neoplasia (sACN) in a single center China.A retrospective cross-sectional consecutive symptomatic healthy individuals who underwent colonoscopy January 2010 March 2016 was performed. Clinicopathological characteritics were documented from...
Abstract Background HBV integration is suspected to be an obstinate risk factor for hepatocellular carcinoma (HCC) in the era of antiviral therapy. Integration events start occur immunotolerance phase, but their fates immune clearance phase have not yet been clarified. Here, we report influences liver damage on and clonal hepatocyte expansion patients with chronic hepatitis B (CHB). Methods breakpoints biopsy samples from 54 CHB were detected using a modified next-generation sequencing...
You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging I1 Apr 2016MP73-08 PROTEINURIA IN PATIENTS UNDERGOING RENAL CANCER SURGERY: IMPACT ON OVERALL SURVIVAL AND STABILITY OF FUNCTION Zhiling Zhang, Juping Zhao, Joseph Zabell, Erick Remer, Jianbo Li, Jack A. Campbell, Wen Dong, Diego Aguilar Palacios, Tulsi Patel, Sevag Demirjian, and Steven C. Campbell ZhangZhiling Zhang More articles by this author , ZhaoJuping Zhao ZabellJoseph Zabell RemerErick Remer LiJianbo...
Background The c-met proto-oncogene ( MET ) serves as a significant primary oncogenic driver in non-small cell lung cancer (NSCLC) and has the potential to fuse with other genes, such KIF5B , although it occurs infrequently. Only limited number of reported cases have examined clinical efficacy crizotinib patients KIF5B-MET gene fusion, no known data regarding acquired resistance its mechanisms. In this report, we present progression female patient diagnosed NSCLC harboring fusion. Case...
Background: MET overexpression represents the most aberration in advanced non-small-cell lung cancer (NSCLC). However, except exon 14 ( METex14) skipping mutation was recognized as a clinical biomarker, role of predictive factor to inhibitor is not clear. Objectives: The purpose pooled analysis explore safety and efficiency gumarontinib, highly selective oral inhibitor, drive-gene negative NSCLC patients with overexpression. Design methods: [immunohistochemistry (IHC) ⩾3+ determined by...
Background: We aimed to determine whether circulating tumor cells (CTCs) and cell-free DNA (cfDNA) aids in prognosis of relapse-free survival (RFS). Methods: Non-small cell lung cancer patients with ALK mutations were recruited prospectively. CTCs cfDNA quantified at different time points. RFS was estimated correlated. Results: Baseline median 16 57 ng/mL declined nine 30 ng/mL, respectively, postsurgery 150 patients. Interestingly, without detectable fared better for RFS. monitoring showed...
Multiple gene-driven programmed cell death 1 ligand (PD-L1)-expressing non-small-cell lung cancer (NSCLC) is very rare. Previous studies have shown that patients with NSCLC anaplastic lymphoma kinase (ALK) gene rearrangement rarely benefit from PD-L1 inhibitors. Besides the secondary mutations in ALK gene, other mechanisms might contribute to tumor resistance tyrosine inhibitors (ALK-TKIs). Herein, we present a case of PD-L1-overexpressing adenocarcinoma harbors both EML4-ALK and BRAF...
You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy I (MP31)1 Apr 2019MP31-18 LONG-TERM ONCOLOGIC OUTCOMES AFTER LAPAROSCOPIC AND ROBOTIC TUMOR ENUCLEATION FOR RENAL CELL CARCINOMA WEN DONG*, TIANXIN LIN, DEHUA OU, WEIBIN XIE, and JIAN HUANG DONG*WEN DONG* More articles by this author , LINTIANXIN LIN OUDEHUA OU XIEWEIBIN XIE HUANGJIAN View All Author Informationhttps://doi.org/10.1097/01.JU.0000557580.33177.ddAboutPDF ToolsAdd to favoritesDownload CitationsTrack...
Objectives Some Western reports have shown a proximal shift in colorectal cancer (CRC), but there are few studies China. This study aimed to provide more information for the management and screening of CRC by investigating trends anatomic distribution among Chinese population recent years. Methods A retrospective was conducted on patients with admitted Digestive Endoscopy Center Tianjin Medical University General Hospital between January 2000 December 2017. Patients were divided into...