A5100421182- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Neurological Disease Mechanisms and Treatments
- RNA Research and Splicing
- Traditional Chinese Medicine Studies
- Bioactive Compounds in Plants
- Protease and Inhibitor Mechanisms
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Medicinal Plants and Neuroprotection
- Molecular Biology Techniques and Applications
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Genetic and phenotypic traits in livestock
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Apelin-related biomedical research
Central South University
2011-2025
Shandong University of Traditional Chinese Medicine
2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2025
Central South University of Forestry and Technology
2025
Shanxi Academy of Medical Sciences
2022-2024
Weatherford College
2023
Heilongjiang University of Chinese Medicine
2013-2023
Wuxi People's Hospital
2023
Nanjing Medical University
2023
National University of Mongolia
2023
ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases. It has long been speculated that “rejuvenation molecules” exist in their blood promote extended lifespan. We unexpectedly discovered longevity exhibit erythrocyte oxygen release function similar young individuals, whereas most elderly show reduced capacity. Untargeted metabolomics profiling revealed are characterized by youth‐like metabolic reprogramming...
This study was to investigate the neuroprotective effect of long noncoding RNAs Metastasis associated lung adenocarcinoma transcript-1 (lncRNA MALAT-1) in Spinal Cord Ischemic/Reperfusion Injury (SCIRI).Quantitative real-time PCR (RT-qPCR) used examine expressions MALAT1, miR-204 and Bcl-2, while western blot performed Bcl-2. Besides, apoptosis evaluated by percentage cell viability apoptotic cells. Neurological evaluation measuring hindlimb locomotor function.The expression MALAT1 Bcl-2...
Premature ovarian failure (POF) contributes to amenorrhoea, infertility, early onset of menostasia and osteoporosis. This study profiled differentially expressed miRNAs for association with POF development. Ovarian tissue samples from 4-vinylcyclohexene diepoxide (VCD)-induced rat normal rats were using miRNA microarrays. A total 63 up-regulated 20 down-regulated in tissues versus the control tissues. qRT-PCR verified some these altered miRNAs, i.e. miR-29a miR-144 tissues, which may target...
The growth and development of skeletal muscle directly impacts the quantity quality pork production. Chinese indigenous pig breeds exotic species vary greatly in terms production performance traits. We present transcriptome profiles 110 samples from Tongcheng (TC) Yorkshire (YK) pigs at 11 developmental periods (30, 40, 55, 63, 70, 90, 105 days gestation, 0, 1, 3, 5 weeks age) using digital gene expression on Solexa/Illumina's Genome Analyzer platform to investigate differences prenatal...
Rutin, a flavonoid glycoside, has been reported to exert neuroprotective effects. Loss of endogenous estrogen and dysregulation the receptor (ER) signaling pathway are associated with increased risk stroke in women after menopause. This study was performed investigate whether rutin could protect against cerebral ischemia by modulating ER pathway. Ovariectomized (OVX) rats were given intraperitoneal injections vehicle (dimethyl sulfoxide), (100 mg/kg body mass) or 17β-estradiol μg/kg for 5...
Neuronal cells are highly sensitive to hypoxia and may be subjected apoptosis when exposed hypoxia. Several apoptosis-related genes miRNAs involve in hypoxia-induced apoptosis. This study aimed examine the role of HIF1α-miR-204-BCL-2 pathway neuronal cells. Annexin V/propidium iodide assay was performed analyze cell AGE1.HN PC12 under hypoxic or normoxic conditions. The expression BCL-2 miR-204 were determined by Western blot qRT-PCR. effects overexpression knockdown on evaluated luciferase...
Polygonatum is a famous traditional Chinese medicine that widely used in China, Korea and Japan. In the last decade, constituents of genus have been reported including steroidal saponins, flavones, alkaloids, lignins, amino acids carbohydrates, some which show biological properties such as antiviral antitumor activity, variable effects on immune system anticoagulant activity. addition, findings provide novel evidence species may contain potential anti-tumor anti-viral proteins for possible...
Photothermal therapy (PTT) has been widely used for the treatment of various medical conditions due to their noninvasive and cost-effective advantages. However, light absorption scattering biosystem limit deep tissue applications conventional PTT probes. In this paper, we proposed sub-10 nm NaNdF4 nanocrystals with both incident emission wavelengths located at optical window. Under 800 laser excitation, maximum light-to-heat conversion efficiency these ultrasmall photothermal agents is...
Abstract Objective In this study, we investigated the impact of perioperative administration Bifidobacterium triplex viable capsules on serum levels circulating miR-21-5p, miR-135-5p, and miR-155-5p in patients with colorectal cancer (CRC). The purpose study is to provide a foundation for future research use enhance postoperative recovery CRC. Methods A total 60 primary CRC admitted Department General Surgery at Shanxi Bethune Hospital between June 2020 December were selected randomly...
Diabetic nephropathy (DN) is serious diabetic complication with capillary injury. Podocyte injury exerts a crucial effect on DN pathogenesis. MicroRNA-503 (miR-503) has been reported in various diseases including DN. Here, we investigated the detailed mechanism of miR-503 podocyte The functional role was cultured podocytes and rats. evaluated by migration apoptosis experiments observed that high glucose elevated time dose-dependent manner. Meanwhile, E2F transcription factor 3 (E2F3), as...
Silybin was known to exert inhibition in prostate cancer, but the underlying mechanism remained largely unknown. This study designed find out potential target of on cancer and explore relative mechanisms.Firstly, we screened possible targets through PubChem database Subpathway - GM. Then DU145 cells were transferred investigate correction about related targets, magnetic bead sorting flow cytometry used sort identify cells. Proliferation, migration invasion ability detected by MTT assay,...
To observe the impact of total flavonoids from Ganshanbian (Herba Hyperici Attenuati) on expression vascular smooth muscle membrane L-type calcium channel alpha1 C subunit (CaL-α1C) and ATP-sensitive K+ (KATP)-Kir6.1 mRNA, explore mechanisms antiarrhythmic effect flavonoids. The treatment group was fed for 7 days by gavage with 100 mg · kg−1 d−1. blank control model were given same amount normal saline d. Arrhythmias induced performing a myocardial ischemia-reperfusion electrocardiogram...
Background: Long noncoding RNA MALAT1 has been previously reported in the carcinogenesis of several tumors, and its potential functional polymorphisms have also investigated various diseases. However, relationship between these susceptibility thyroid cancer still largely unknown. In present study, we aimed to explore association (TC) susceptibility, as well biological function TC. Methods: We conducted a case-control study with 1134 papillary (PTC) patients 1228 controls evaluate correlation...
Jinlingzi powder comprises Melia toosendan Sieb. et Zucc. and Corydalis yanhusuo (Y.H. Chou & Chun C.Hsu) W.T. Wang ex Z.Y. Su C.Y. Wu is usually applied in clinic as traditional Chinese medicine for pain. The present study aims to investigate the therapeutic actions of its extracted components theirs treatment mechanism on acetic acid induced-gastric ulcer rats. gastric model was induced by administration rats (84 male). water decoction, polysaccharide, nonalkaloid alkaloid were used...
Purpose: The purpose of this study was to identify aberrant long non-coding RNAs (lncRNAs) and explore the predictive value lncRNA expression patterns on risk brain metastases (BMs) in patients with limited-stage small-cell lung cancer (SCLC). Patients Methods: We executed an array mRNA chip assays examine peripheral blood mononuclear cells obtained from SCLC BMs compared against those without lncRNAs associated BMs. Validation performed clinical data further confirm relationship between BM....
Two new phenolic acid helisterculins C (1) and D (2) were isolated from the whole plant of Clerodendranthus spicatus. Their structures elucidated on basis 1D 2D NMR, MS, CD analysis. Compound 1 possesses an unusual bicyclol [2. 2. 2] octane moiety which is rare in previously derivatives. The two compounds tested vitro for neuroprotective activities against 6-OHDA-induced cell death SH-SY5Y cells, result showed that 2 displayed moderate activity with IC50 values 17.4 21.3 μM, respectively.
OBJECTIVE Micro RNA ‐1254 (mi R ‐1254) has not been studied in colorectal cancer ( CRC ) to date. This study aimed investigate the inhibitory mechanism of mi tumorigenesis. METHODS MiR‐1254 expression was examined using real‐time polymerase chain reaction and adjacent non‐tumorous tissues. The correlation between miR‐1254 expressions proliferation migration cells determined CCK ‐8 transwell assays. sequencing used identify differentially expressed genes downstream from . A luciferase...
To study the role of asarinin on collagen-induced arthritis (CIA) and its treatment mechanism dendritic cells (DCs) T cells. Before onset arthritis, were given orally to CIA mouse. Macroscopic scoring micrometer caliper measurement used assess arthritis. The occurrence cartilage destruction bone erosion assessed by histology knee. Sandwich enzyme-linked immunosorbent assay (ELISA) PCR level cytokines in hindpaw arthritic joint. CD11c MicroBeads employed isolate CD11c+ from spleen....
Background: Many studies have investigated the association between matrix metalloproteinase polymorphisms and lung cancer susceptibility. However, results are still controversial. To clarify these associations, we conducted a meta-analysis. Methods: A systematic search of was in PubMed, Embase, China National Knowledge Infrastructure. Overall subgroup analysis stratified by ethnicity conducted. OR with 95% CI used to assess strength association. Furthermore, false-positive report probability...
Colorectal cancer (CRC) is the most common malignancy worldwide, and its underlying molecular mechanisms remain largely unexplored. Accumulating evidences indicate cancer-associated fibroblasts (CAFs), abundant stromal cell population in tumor microenvironment, play a key role development. Herein, we have successfully isolated CAFs paired normal (NFs) from colorectal tissues (n=10). By using multiplex cytokine profiling assay, identified IL-6 as major released by CAFs. Co-culturing of with...