A5085826663- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Mesoporous Materials and Catalysis
- Cancer-related molecular mechanisms research
- Plasma Diagnostics and Applications
- Plasma Applications and Diagnostics
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Graphene and Nanomaterials Applications
- Neuroendocrine Tumor Research Advances
- Immunotherapy and Immune Responses
- Renal cell carcinoma treatment
- Effects of Vibration on Health
- Gastrointestinal Tumor Research and Treatment
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Pancreatitis Pathology and Treatment
- RNA Interference and Gene Delivery
- Gastrointestinal disorders and treatments
- Advanced Nanomaterials in Catalysis
- Cancer-related gene regulation
Huashan Hospital
2013-2024
Fudan University
2013-2024
Guangdong Provincial Occupational Disease Prevention Hospital
2022-2023
Air Force Institute of Aviation Medicine Affiliated Hospital
2015-2021
Yunnan University
2021
National Natural Science Foundation of China
2017
North China Electric Power University
2016
Linyi University
2016
Shanghai Medical College of Fudan University
2011-2014
Zhangzhou Municipal Hospital of Fujian Province
2010
Functional core-shell mesoporous microspheres with integrated functions, controlled structure, and surface properties morphologies have received increasing attention due to their excellent physicochemical properties. Herein, magnetic materials cauliflower-like morphology tunable roughness been synthesized through a kinetics-controlled interface co-assembly deposition of mesostructured nanocomposites on Fe3O4@RF (RF refers resorcinol formaldehyde resin). The obtained microspheres, via this...
Magnetic mesoporous silica microspheres with core–shell structure and large pores are highly desired in macromolecules delivery biocatalysis, biospeparation, adsorption. In this work, a controllable solvent evaporation induced solution-phase interface co-assembly approach was developed to synthesize structural magnetic ultralarge mesopore size (denoted as LP-MMS). The synthesis achieved by employing large-molecular-weight amphiphilic block copolymers poly(ethylene oxide)-block-poly(methyl...
Abstract Chemiluminescence immunoassay exhibits high sensitivity and signal‐to‐noise ratio, thus attracting great attention in the early diagnosis dynamic monitoring of diseases. However, collection conventional flash‐type chemiluminescence signal (<5 s) relies heavily on automatic sampling reading instrument. Herein, a novel core‐satellite multifunctional immunosensor is designed for efficient enrichment highly sensitive determination cancer biomarker carcinoembryonic antigen (CEA) with...
To establish an orthotopic mouse model of pancreatic cancer that mimics the pathological features exocrine adenocarcinoma.Pan02 cells were suspended in low-temperature Matrigel and injected into parenchyma tails C57BL/6 mice, with phosphate buffered saline (PBS) serving as a control. Primary implanted tumors confirmed pathologically. The rate tumor formation intraperitoneal implantation two groups compared at different time points after injection. Leakage intra-abdominal dispersion PBS, both...
Benefiting from the advantages of minimal invasiveness, painlessness, and ease to use, microneedle patches (MPs) have been extensively studied in biomedical field through a physical penetration enhancement pathway. This study systematically summarizes preparation methods, function optimization, diagnostic therapeutic applications MPs. First all, raw materials methods commonly used different processes for MPs are highlighted. Then, corresponding solutions problems facing MPs, such as poor...
Objective To determine if the density of FOXP3+ lymphocytes in primary tumors and lymph nodes pancreatic cancer correlates with presence node metastases. Methods lymphocyte tissue draining was measured using immunohistochemistry. We analyzed clinical pathological aspects associated accumulation cancer. also correlation nodal status distance from tumor. Results significantly higher than paratumoral tissue. The local tumor correlated histological grade overall status. Furthermore, positive...
miRNA-218 is a highlighted tumor suppressor and its underlying role in progression still unknown. Here, we restored the expression of pancreatic cancer to clarify function potent downstream pathway miRNA-218. The expressions both target gene ROBO1 were revealed by RT-PCR western blotting analysis. Transfection precursor mimics luciferase assay performed elucidate regulation mechanism between ROBO1. Cells, stably expressing followed forced mutant ROBO1, established through co-transfections...
Abstract Diverse diseases and increasing prevalence pose a serious threat to public health. Point‐of‐care testing (POCT) techniques have imposed superior requirements over sensitivity, selectivity, robustness, affordability, high‐throughput. However, transient signal, complex sample pretreatment, low signal‐to‐noise ratio make POCT severely limited in detection accuracy, efficiency, sensitivity. Here, an enzyme‐assisted magnetic large‐mesoporous nanoreactor (FS) is constructed for achieving...
Abstract With the development of nanotechnology, special attention has been given to nanomaterial application in tumor treatment. Here, a modified desolvation-cross-linking method was successfully applied fabricate gemcitabine-loaded albumin nanospheres (GEM-ANPs), with 110 and 406 nm mean diameter, respectively. The aim this study assess drug distribution, side effects, antitumor activity GEM-ANPs vivo . metabolic viability flow cytometry analysis revealed that both GEM-ANPs, especially...
AIM:To assess the efficacy of cross-sectional multidetector computed tomography (MDCT) imaging without arterial reconstruction to identify aberrant right hepatic artery (RHA) and celiac stenosis (CAS) in patients scheduled for pancreaticoduodenectomy. METHODS:Patients with peri-ampullary pancreatic head tumors who underwent routine preoperative MDCT subsequent (CT) angiography (CTA), conventional or pancreaticoduodenectomy between September 2007 August 2013 were identified.Retrospective...
Abstract Primary retroperitoneal cavernous hemangioma (PRCH) in an adult is extremely rare. We report on the diagnosis and treatment of a patient with PRCH subtle clinical features atypical findings imaging scans. A 38-year-old man was admitted to hospital 5-day history epigastralgia after alcohol drinking. Using various methods, we found giant cyst-like mass compressing surrounding organs. Surgical resection tumor performed, be measuring 90 × 80 60 mm, thick fibrotic wall extensive...
Afferent loop syndrome (ALS) is a rare and dreaded complication after pancreaticoduodenectomy (PD). Malignant ALS PD usually difficult to manage due patients' poor condition. Effective safe therapeutic strategies for these patients are reported scarcely at present.
In this study, novel mesoporous siliceous vesicles with ultrathin walls (50 nm in thickness) and large cavities were synthesized through a facile biliquid-interface co-assembly method by using cetyltrimethylammonium bromide as structure-directing agent tetraethoxysilane silica source. Various synthesis parameters (stirring rate, ionic strength, reaction temperature) have been investigated found to affect the interface process. The obtained are highly water-dispersible mesopores (6.7 nm)...
Abstract Background The molecular signature underlying pancreatic ductal adenocarcinoma (PDAC) progression may include key proteins affecting the malignant phenotypes. Here, we aimed to identify implicated in PDAC with different tumour-node-metastasis (TNM) stages. Methods Eight-plex isobaric tags coupled two-dimensional liquid chromatography–tandem mass spectrometry were used analyse proteome of tissues TNM A loss-of-function study was performed evaluate oncogenic roles WD repeat-containing...
In order to study the stability of gliding arc plasma discharge under mal-conditions, an experimental system for studying high air pressure alternating current rotating is built. The characteristics, motion characteristics and spectral are analyzed experimentally. Experimental results show that voltage, energy increase in with pressure. As rises 0.52 MPa, increases from 84.74 147.13 J. With gas pressure, breakdown frequency does not change monotonically, but reaches a maximum value 26.55 kHz...