A5101501143- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Nanoplatforms for cancer theranostics
- Covalent Organic Framework Applications
- Hemoglobin structure and function
- Nanoparticle-Based Drug Delivery
- Advanced Photocatalysis Techniques
- Microbial metabolism and enzyme function
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Cancer Genomics and Diagnostics
- Glycosylation and Glycoproteins Research
- Adenosine and Purinergic Signaling
- Biochemical and Molecular Research
- Nanocluster Synthesis and Applications
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
Huashan Hospital
2016-2024
Fudan University
2015-2024
Guangdong University of Technology
2024
State Key Laboratory of Food Science and Technology
2021
Jiangnan University
2021
Background and objectives: Gemcitabine (Gem) is far from satisfactory as the first-line regimen for pancreatic cancer, emergence of albumin nanoparticles offers new hope delivery Gem. In this study, Gem-loaded human serum (Gem-HSA-NPs) were successfully synthesized, characterized, tested on a BxPC-3 cell line both in vitro vivo. Materials methods: 4- N -myristoyl-gemcitabine (Gem-C14) was obtained first by coupling myristoyl with 4-amino group The Gem-HSA-NPs then prepared nanoparticle...
Abstract Hypoxic microenvironment is common in solid tumors, particularly pancreatic ductal adenocarcinoma (PDAC). The Warburg effect known to facilitate cancer aggressiveness and has long been linked hypoxia, yet the underlying mechanism remains largely unknown. In this study, we identify that lysyl oxidase-like 2 (LOXL2) a hypoxia-responsive gene essential for PDAC. LOXL2 stabilizes hypoxia-inducible factor 1α (HIF1α) from prolyl hydroxylase (PHD)-dependent hydroxylation via hydrogen...
Abstract Bidirectional signal transduction between tumor epithelial cells and microenvironment (TME) is important for development. Here we show that Lin28b/let-7 pathway indispensable modulating the expression of Wnt5a in epithelium, which could be secreted then up-regulates Lin28b cancer-associated fibroblasts (CAFs). Moreover, demonstrate CAFs promoted growth PDAC by inducing cytokine PCSK9’s production. Using an orthotopic mouse model PDAC, find depletion reduced weight, highlighting...
Reprogrammed glucose and glutamine metabolism are essential for tumor initiation development. As a branch of metabolism, the hexosamine biosynthesis pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) contributes to O-GlcNAcylation process. However, spectrum HBP-dependent tumors mechanisms by which HBP promotes aggressiveness remain areas active investigation. In this study, we analyzed activity its prognostic value across 33 types human cancers. Increased was...
Abstract Background The molecular signature underlying pancreatic ductal adenocarcinoma (PDAC) progression may include key proteins affecting the malignant phenotypes. Here, we aimed to identify implicated in PDAC with different tumour-node-metastasis (TNM) stages. Methods Eight-plex isobaric tags coupled two-dimensional liquid chromatography–tandem mass spectrometry were used analyse proteome of tissues TNM A loss-of-function study was performed evaluate oncogenic roles WD repeat-containing...
Objective: Pancreatic cancer (PC) is a malignant tumor with limited therapeutic choices and extremely poor prognosis. Personalized therapy based on gene alternations promising choice. Considering heterogeneity, the practice of ctDNA analysis has drawn attention. Here, we try to assess applicability in PC. Methods materials: Next generation sequencing (NGS) was performed from blood samples 223 PC patients tissue sample 564 patients. Genomic data TCGA database were also utilized. In addition,...
The visible-light-driven photocatalysts for removing heavy metal ions in wastewater has received great attention. However, the exploitation of semiconductor materials with high photocatalytic activity and easily recyclability remains a challenge. Herein, recyclable carbon cloth-supported porous CdS nanorods was favourably fabricated by two-step hydrothermal treatment using AgVO3 nanowires as templates. as-prepared large specific surface area exhibited an enhanced adsorption capacity Cr(VI),...
In this presented work, a facile and efficient method was established for the detection of chloramphenicol (CAP) based on target-induced structure transformation aptamer. This aptamer DNA with hairpin can coincidentally serve as template synthesis bright silver nanoclusters (quantum yield 16.36%). The binding CAP could cause destruction structure, resulting in quenching fluorescence (AgNCs). It costs less than 10 minutes to complete assay, excellent sensitivity achieved limit 0.052 nmol/L....