A5060996227- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Airway Management and Intubation Techniques
- Esophageal and GI Pathology
- Asthma and respiratory diseases
- Lung Cancer Research Studies
- Inhalation and Respiratory Drug Delivery
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Pleural and Pulmonary Diseases
- Circular RNAs in diseases
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Foreign Body Medical Cases
- Gastric Cancer Management and Outcomes
- Respiratory Support and Mechanisms
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Congenital Diaphragmatic Hernia Studies
- Mesenchymal stem cell research
- Vascular Anomalies and Treatments
Changhai Hospital
2016-2025
Second Military Medical University
2016-2025
Yan'an University
2025
Euromedica
2024
Shanghai East Hospital
2019-2024
Fudan University
2008-2023
Shanghai FRP Research Institute (China)
2023
Zhongshan Hospital
2015-2023
International Hellenic University
2023
University of Shanghai for Science and Technology
2022-2023
The deubiquitinating enzyme USP14 has been identified and biochemically studied, but its role in lung cancer remains to be elucidated. aim of this study was evaluate the prognostic significance patients with adenocarcinoma define cell proliferation. mRNA levels different non-small (NSCLC) lines were detected by real-time qPCR. protein surgically resected samples from NSCLC patients, lines, immunohistochemistry or Western blot. correlation expression clinical characteristics prognosis...
Tracheobronchial foreign bodies (FBs) are frequently present in adults. This study reports our experience with the managements of FB and FB-related complications using flexible bronchoscopy.We retrospectively reviewed adult patients FBs treated between 2001 2011 China. The demographic endoscopic data were collected analyzed.A total 200 (136 men 64 women) an average age 51 years analyzed. most common included bones (51.0%), nut shells (15.0%), food boluses (7.0%), plastic toys or pen caps...
This study aimed to investigate the effects of long non-coding RNA ROR (regulator reprogramming) on cisplatin (DDP) resistance in patients with non-small-cell lung cancer by regulating PI3K/Akt/mTOR signaling pathway. Human cisplatin-resistant A549/DDP cell lines were selected and divided into control group, negative si-ROR over-expression Wortmannin + group. MTT assay was used determine optimum inhibitory concentration DDP. Quantitative real-time polymerase chain reaction western blotting...
Abstract Autophagy plays critical roles in airway inflammation and fibrosis-mediated remodeling many factors including proinflammatory cytokines related pathways are involved the process. The aim of present study was to examine role epithelial microRNAs (miRNAs) autophagy-mediated identify underlying mechanisms. Serum miR-34/449, inflammatory factors, autophagy fibrosis-related proteins were determined by real-time PCR, enzyme-linked immunosorbent assay western blotting 46 subjects with...
Asthma is the most common chronic disease and characterized by airway remodeling inflammation. Increasingly, studies have found that activation M1 phenotypic transformation of macrophages play important roles in asthma progress, including remodeling. However, reversal to M2 phenotype has been shown attenuate Exosomes are nano-sized extracellular vesicles derived from endosomes; they direct governing physiological pathological conditions intracellular transfer bioactive cargo, such as...
Background: Lung cancer is the leading cause of cancer-related mortality worldwide, with near 1.4 million deaths each year. NSCLC accounts for nearly 85% all case lung cancer. MiRNAs play important roles in regulation gene expression at post-transcriptional level. profiles may predict prognosis and disease recurrence early-stage NSCLC. Our previous study proved that over-expression ubiquitin specific peptidase 14 (USP14), a deubiquitinating enzyme, was associated favorable patients promoted...
Background and Objectives: Endobronchial ultrasound elastography is a new technique for describing the stiffness of tissue during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The aims this study were to investigate diagnostic value (EBUS) distinguishing difference between benign malignant lymph nodes among mediastinal hilar node. Materials Methods: From June 2015 August 2015, 47 patients confirmed node enlargement through examination Computed tomography (CT)...
Abstract Intratumoral heterogeneity in lung cancer is essential for evasion of immune surveillance by tumor cells and establishment immunosuppression. Gathering data reveal that circular RNAs (circRNAs), play a role the pathogenesis progression cancer. Particularly Kras-driven circRNA signaling triggers infiltration myeloid-associated macrophages microenvironment thus establishing deregulation, immunosuppression but exact pathogenic mechanism still unknown. In this study, we investigate...
Identifying inflammation-induced leukocyte subsets and their derived circulating factors has been instrumental in understanding the progession of ALI/ARDS. Nevertheless, how primary non-leukocyte populations distal organs contribute to ALI/ARDS remains poorly defined. Here, we report one population erythroblast-like cells (Ter-cells) deriving from megakaryocyte- erythroid progenitor with a unique Ter-119+CD45-CD71+ phenotype Ter-cells induced by spleen are chemoattracted into lung inhibit...
A study was conducted on the vascular floras of Ziwuling Mountains in Shaanxi Province to establish a foundational database, providing data support for conservation and utilization Mountains’ plant diversity resources. Based field surveys literature references, composition geographical elements area were analyzed. The species richness floristic similarity coefficients compared with other Ordos Platform. results as follows: (1) comprised 120 families, 498 genera, 965 species, superrosids...
As acute inhalational injury is an uncommon presentation to most institutions, a standard approach its assessment and management, especially using flexible bronchoscopy, has not received significant attention. The objective of this study evaluate the value bronchoscopy as part evaluation management patients with lung injury. Twenty-three cases were treated in our three hospitals after fire residential building. twenty that underwent their are included analysis. After admission, first was...
Background Though the possibility of using malignant pleural effusions (MPEs) as alternatives for metastatic tumor tissues (MPTTs) in epidermal growth factor receptor (EGFR) mutation test has been examined, due to lack studies comparing results matching MPEs and MPTTs, clinical value advanced adenocarcinoma patients with is not confirmed. Methods EGFR statuses MPE supernatants cell blocks, 41 lung diagnosed by thoracoscopy were analyzed amplification refractory system (ARMS). Results...
Asthma is a worldwide common chronic airway disease that cannot be cured and results in the huge burden public health. Oxidative stress was considered an important mechanism pathogenesis of asthma. Hydrogen gas been demonstrated to function as novel antioxidant exert therapeutic activity number diseases this nontoxic asthma unclear. The purpose study aims examine effect inhalation hydrogen on pathophysiology mouse model A murine ovalbumin (OVA)-induced allergic inflammation used study....
The present study explored the association between KRAS proto‑oncogene GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3‑kinase catalytic subunit α (PIK3CA) and tumor protein p53 (TP53) mutations, clinical features survival prognosis in 50 patients with non‑small cell lung cancer (NSCLC). most common concurrent single gene mutation was TP53, followed by PIK3CA. Co‑existing mutations were found 17 patients. KRAS, PIK3CA TP53 associated carbohydrate antigen 19‑9 expression, invasive...
Immunosuppressive chemoresistance is a major burden in lung cancer. Recent data reveal that long noncoding RNAs (lncRNAs) present the tumor microenvironment are implicated chemoresistant-related immune deregulation, and metastasis but their exact pathogenic role still unknown. In this study, we investigate of lncRNA PCAT-1 chemoresistant immunosuppression its involvement stroma remodeling. Findings to regulate Kras-related through increased expression immunosuppressive micrornas...
Biodegradable MDSCs-targeted nanospheres containing <sc>l</sc>-Norvaline and Sunitinib in order to facilitate inhibition of tumor-supporting immunosuppression.
Background: Bronchoscopy has gradually become valuable armamentarium in evaluating and applying endoscopic therapy to peripheral pulmonary lesions (PPLs) around the world.We aimed make a comprehensive understanding of application bronchoscopy diagnosis treatment PPLs China.Methods: A cross-sectional survey was carried out China between January 2022 March 2022.The form an online questionnaire which filled with real-time data by respondents.Results: total 347 doctors from 284 tertiary...