A5067583322- Mesenchymal stem cell research
- Dental Implant Techniques and Outcomes
- Cancer-related molecular mechanisms research
- Dental Radiography and Imaging
- MicroRNA in disease regulation
- Periodontal Regeneration and Treatments
- Wound Healing and Treatments
- Autophagy in Disease and Therapy
- Electrospun Nanofibers in Biomedical Applications
- Hormonal Regulation and Hypertension
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Orthodontics and Dentofacial Orthopedics
- Immune Response and Inflammation
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Facial Trauma and Fracture Management
- Occupational and environmental lung diseases
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Circular RNAs in diseases
- Oral health in cancer treatment
- Renin-Angiotensin System Studies
- Adipose Tissue and Metabolism
- Bone Tissue Engineering Materials
Southern Medical University
2016-2025
Yanbian University
2003-2025
Sun Yat-sen University
2011-2024
Minda Hospital
2024
Eighth Affiliated Hospital of Sun Yat-sen University
2022-2024
Sun Yat-sen Memorial Hospital
2024
Nanjing University
2024
Jining Medical University
2008-2024
Xiamen University
2016-2024
Nanfang Hospital
2024
Growing evidence indicates that bone marrow-derived mesenchymal stem cells (BM-MSCs) enhance wound repair via paracrine. Because the extent of environmental oxygenation affects innate characteristics BM-MSCs, including their stemness and migration capacity, current study set out to elucidate compare impact normoxic hypoxic cell-culture conditions on expression secretion BM-MSC-derived paracrine molecules (e.g., cytokines, growth factors chemokines) hypothetically contribute cutaneous healing...
Abstract Mesenchymal stem cells (MSCs) are a common kind of multipotent cell in vivo, but their heterogeneity limits further applications. To identify MSC subpopulations and clarify relationships, we performed mapping bone-marrow-derived MSCs through single-cell RNA (scRNA) sequencing. In our study, three main subpopulations, namely, the stemness subpopulation, functional proliferative were identified using marker genes bioinformatic analyses. Developmental trajectory analysis showed that...
Burn infection delays wound healing and increases the burn patient mortality. Consequently, a new dressing with antibacterial anti-inflammatory dual properties is urgently required for healing. In this study, we propose combination of methacrylate gelatin (GelMA) hydrogel system silver nanoparticles embed in γ-cyclodextrin metal-organic frameworks (Ag@MOF) hyaluronic acid-epigallocatechin gallate (HA-E) treatment. Ag@MOF used as an agent epigallocatechin (EGCG) has exhibited biological...
Cancer metastasis that is resistant to conventional therapies has become a major cause of patient death. Recent reports indicate the neutrophil extracellular trap (NET) closely associated with cancer distant metastases, and cell-free DNA NETs been identified as ligand transmembrane protein CCDC25 cells, acting chemokine induce cell migration organs. In this work, we present poly(aspartic acid) based-cationic materials interfere interaction between NET-DNA CCDC25, furthermore inhibit...
Scar contraction frequently happens in patients with deep burn injuries. Hitherto, porcine dermal extracellular matrix (dECM) has supplied microenvironments that assist wound healing but fail to inhibit scar contraction. To overcome this drawback, we integrate dECM into three-dimensional (3D)-printed analogues (PDA) prevent We have developed thermally gelled, non-rheologically modified powder (dECMp) inks and successfully transformed them PDA was endowed a micron-scale spatial structure. The...
Severe burn wounds face two primary challenges: dysregulated cellular impairment functions following infection and an unbalanced wound hydration microenvironment leading to excessive inflammation collagen deposition. These results in hypertrophic scar contraction, causing significant deformity disability survivors.
Chemotherapy-induced oral mucositis (CIOM) is a prevalent complication of chemotherapy and significantly affects the treatment process. However, effective for CIOM lacking due to unique environment cavity single effect current drug delivery systems. In this present study, we propose an innovative approach by combining methacrylate-modified human recombinant collagen III (rhCol3MA) hydrogel system with hyaluronic acid-epigallocatechin gallate (HA-E) dopamine-modified methacrylate-alginate...
<title>Abstract</title> <bold>Background</bold> Skin wound healing is a complex physiological process influenced by multiple factors, including the patient's overall health status. Exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-exos) have demonstrated considerable potential in enhancing repair. This study investigates mechanisms through which hUCMSC-exos facilitate skin and evaluates their application combination with hydrogels for clinical treatment....
A series of retrospectively recorded patients with cleft lip and palate was uniquely investigated to demonstrate analyze the complications after repairing operations in a selected Chinese population.From January 2005 2012, group 2100 and/or who have complete records were chosen from large sample units. Complete data retrieved, including sex, age, clinical classification, surgical modality, complications, follow-up results. The classified into 2 categories: early long-term complications....
Abstract This retrospective study used a population-based national registry to determine the impact of local treatment modalities on survival in patients with metastatic esophageal cancer (EC). The Surveillance Epidemiology and End Results (SEER) database was identify EC from 1988 2012. A total 9,125 were identified. There 426 underwent primary surgery, 4,786 administered radiotherapy (RT) alone, 847 surgery plus RT 3,066 without any treatment. Multivariate analysis results indicated that...
Abstract Background The immune system and the skeletal have complex interactions in bone marrow even joints, which has promoted development of concept osteoimmunology. Some evidence indicated that T cells B contribute to balance between resorption formation bone. However, there been little discussion on regulation CD4 + lymphocytes by involved metabolism. Mesenchymal stem (MSCs), exert core functions related immunoregulation osteogenic differentiation, are crucial linked both metabolism...
We call $F:\{0, 1\}^n\times \{0, 1\}^n\to\{0, 1\}$ a symmetric XOR function if for $S:\{0, 1, ..., n\}\to\{0, 1\}$, $F(x, y)=S(|x\oplus y|)$, any $x, y\in\{0, 1\}^n$, where $|x\oplus y|$ is the Hamming weight of bit-wise $x$ and $y$. show that such function, (a) deterministic communication complexity always $\Theta(n)$ except four simple functions have constant complexity, (b) up to polylog factor, both error-bounded randomized quantum with entanglement are $\Theta(r_0+r_1)$, $r_0$ $r_1$...
Changes in oxygen concentration may influence various innate characteristics of stem cells.The effects varying on human periodontal ligament cells (HPDLSCs) has not been explored, particularly under hypoxia-related conditions.First, HPDLSCs were cultured from the periodontium teeth using outgrowth method.STRO-1 and CD146 expression was investigated by flow cytometry.To detect multilineage differentiation capacities HPDLSCs, osteogenic-like adipogenic-©FUNPEC-RP www.funpecrp.com.brGenetics...