A5004098810- Wound Healing and Treatments
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- Dermatologic Treatments and Research
- Tissue Engineering and Regenerative Medicine
- Medical and Biological Ozone Research
- Cancer, Hypoxia, and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Protein Degradation and Inhibitors
- Autoimmune Bullous Skin Diseases
- Fungal Infections and Studies
- Click Chemistry and Applications
- Lipid metabolism and disorders
- Pluripotent Stem Cells Research
- Biomedical Ethics and Regulation
- Graphene and Nanomaterials Applications
- Bone Tissue Engineering Materials
- Hydrogen's biological and therapeutic effects
- Medical Research and Treatments
- Computational Drug Discovery Methods
- Cancer Genomics and Diagnostics
- Sarcoma Diagnosis and Treatment
- Connective Tissue Growth Factor Research
- 3D Printing in Biomedical Research
Sun Yat-sen University
2006-2024
The First Affiliated Hospital, Sun Yat-sen University
2006-2024
Burn infection delays wound healing and increases the burn patient mortality. Consequently, a new dressing with antibacterial anti-inflammatory dual properties is urgently required for healing. In this study, we propose combination of methacrylate gelatin (GelMA) hydrogel system silver nanoparticles embed in γ-cyclodextrin metal-organic frameworks (Ag@MOF) hyaluronic acid-epigallocatechin gallate (HA-E) treatment. Ag@MOF used as an agent epigallocatechin (EGCG) has exhibited biological...
Abstract Background The biological role of miR-203 and the underlying mechanisms on proliferation epidermal stem cells (ESCs) have not yet been reported during progression chronic wound healing in diabetes mellitus. Our previous studies observed that expression showed a marked upregulation ESC capacity was impaired mellitus skin wounds rats. Methods Wound models were established normal rats with type 2 diabetes. Expression level alteration ESCs’ number function detected. ESCs isolated from...
Melanomas are skin malignant tumors that arise from melanocytes which primarily treated with surgery, chemotherapy, targeted therapy, immunotherapy, radiation etc. Targeted therapy is a promising approach to treating advanced melanomas, but resistance always occurs. This study aimed at identifying the potential target genes and candidate drugs for drug-resistant melanoma effectively computational methods.Identification of associated melanomas was conducted using text mining tool...
Dermal substitutes (DS) have been widely used in wound repair, but the survival rate of skin grafts with a DS remains an important challenge regenerative medicine. In this study, we porcine dermis-derived decellularized extracellular matrix (dECM) to construct optimized 3D-printed DS, which exhibited desired structure, good mechanical properties, and biocompatibility. Meanwhile, constructed prevascularized human mesenchymal stem cell sheets (PHCS) certain microstructure, could enhance...
Objective To investigate the influence of granulocyte macrophage colony stimulatingfactor （ GM-CSF） on expression angiopoietin-1 （Ang-1） in deep partial thickness bum wound 1rats. Methods The models wounds back Spregue-Dawley SD）rats were established. paired same rats randomly divided into GM-CSF treatment（test） and control groups by self-control. Tissue samples harvested from 1st,3rd,7th, 14th 21st day respectively after bums. mRNA Ang-1 was detected using re-al-time reverse...
Objective To discuss the influence of aerosol bioelectricity on expression interleukin (IL) -8 and IL-10 in wound healing burned rats. Methods The deep Ⅱ degree scalding models were established Sprague Dawley (SD) Rats randomly divided into experimental group (n1 =20) control (n2 =20). rats treated with bioelectricity.Samples collected at first to eleventh day post-scalding. Immunohistochemistry image analysis methods conducted examine IL-8 both groups. Results average time was 7. 00 ± 1. 15...