A5024997634- Wound Healing and Treatments
- Dermatologic Treatments and Research
- Skin Protection and Aging
- Mesenchymal stem cell research
- Phytochemicals and Antioxidant Activities
- Ferroptosis and cancer prognosis
- Inflammasome and immune disorders
- Pressure Ulcer Prevention and Management
- Extracellular vesicles in disease
- Antioxidant Activity and Oxidative Stress
- Organ and Tissue Transplantation Research
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- Corneal Surgery and Treatments
- melanin and skin pigmentation
- Laser Applications in Dentistry and Medicine
- Natural product bioactivities and synthesis
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Advanced Glycation End Products research
- Tendon Structure and Treatment
- Diabetic Foot Ulcer Assessment and Management
- Peptidase Inhibition and Analysis
The First Affiliated Hospital, Sun Yat-sen University
2022-2025
Sun Yat-sen University
2022-2025
Guangzhou Medical University
2024
Guangzhou Women and Children Medical Center
2024
Abstract The protracted transition from inflammation to proliferation in diabetic wound healing poses significant challenges, exacerbated by persistent inflammatory responses and inadequate vascularization. To address these issues, a novel nanozymatic therapeutic approach utilizing asymmetrically structured MnO₂–Au–mSiO₂@aFGF Janus nanoparticles is engineered. Nanozymes featuring mSiO₂ head MnO₂ extensions, into which acidic fibroblast growth factor (aFGF) encapsulated, resulting...
Severe burn wounds face two primary challenges: dysregulated cellular impairment functions following infection and an unbalanced wound hydration microenvironment leading to excessive inflammation collagen deposition. These results in hypertrophic scar contraction, causing significant deformity disability survivors.
Hypertrophic scar (HS) is a common fibroproliferative disorders with no fully effective treatments. The conversion of fibroblasts to myofibroblasts known play critical role in HS formation, making it essential identify molecules that promote myofibroblast dedifferentiation and elucidate their underlying mechanisms. In this study, we used comparative transcriptomics single-cell sequencing key pathways mediate fibrosis transdifferentiation. Epidermal stem cell-derived extracellular vesicles...
Abstract Hypertrophic scar (HS) is a prevalent yet unresolved wound healing complication characterized by persistent hyperactive and proliferative fibroblasts, leading to excessive extracellular matrix (ECM) synthesis collagen contraction. Our previous studies have identified epidermal stem cells (ESCs) as critical for HS remodeling, with its vesicles (EVs) playing vital role. However, the specific mechanisms remain unclear. In this study, we first discovered that ESC-EVs could effectively...
Diabetic foot ulcer (DFU) is one of the most common and complex complications diabetes, but underlying pathophysiology remains unclear. Single-cell RNA sequencing (scRNA-seq) has been conducted to explore novel cell types or molecular profiles DFU from various perspectives. This study aimed comprehensively analyze potential mechanisms impaired re-epithelization in a single-cell perspective. We scRNA-seq on tissues human normal skin, acute wound, investigate epidermal differentiation...
Abstract Background Hypertrophic scar (HS) is a common fibroproliferative skin disease that currently has no truly effective therapy. Given the importance of phosphatidylinositol 3-kinase catalytic subunit alpha (PIK3CA) in hypertrophic formation, development therapeutic strategies for endogenous inhibitors against PIK3CA great interest. Here, we explored molecular mechanisms underlying protective effects miR-203a-3p (PIK3CA inhibitor) excessive scar. Methods Bioinformatic analysis,...
Owing to the persistent inflammatory microenvironment and unsubstantial dermal tissues, chronic diabetic wounds do not heal easily their recurrence rate is high. Therefore, a substitute that can induce rapid tissue regeneration inhibit scar formation urgently required address this concern. In study, we established biologically active substitutes (BADS) by combining novel animal tissue-derived collagen dermal-replacement scaffolds (CDRS) bone marrow mesenchymal stem cells (BMSCs) for healing...
Hypertrophic scarring (HS) is a common skin injury complication with unmet needs. Verteporfin (VP) should be an ideal HS-targeted therapeutic drug due to its efficient fibrosis and angiogenesis inhibitory abilities. However, application restricted by side effects such as dose-dependent cytotoxicity on normal cells. Herein, the bioadhesive nanoparticles encapsulated VP (VP/BNPs) are successfully developed attenuate of enhance HS inhibition limiting releasing slowly stably in lesion site but...
Skin cutaneous melanoma (SKCM) is the most lethal skin cancer with an increasing incidence worldwide. The poor prognosis of SKCM urgently requires us to discover prognostic biomarkers for accurate therapy. As a regulator DNA replication, TIMELESS (TIM) has been found be highly expressed in various malignancies but rarely reported SKCM. objective this study was evaluate relationship between TIM and tumorigenesis prognosis.We obtained RNA sequencing data from TCGA GTEx analyze expression...
Skin cutaneous melanoma (SKCM) is the most aggressive skin cancer, accounting for more than 75% mortality rate of skin-related cancers. As a newly identified programmed cell death, pyroptosis has been found to be closely associated with tumor progression. Nevertheless, prognostic significance in SKCM remains elusive.A total 469 samples and 812 normal were obtained from The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases. Firstly, differentially expressed...
<title>Abstract</title> The present study identified various compounds, such as chlorogenic acid, gallic quercetin, and (E)-Ferulic acid in the kunzea ericoides (kanuka) leaf extract, showing its potential use maintaining skin health. influence of kanuka extract upon epidermal cells concerning cytotoxicity vitro activities moisturisation, anti-oxidation, UVB protection, anti-melanogenesis effects were explored study. Kanuka demonstrated significant promotion proliferation HaCaT B16F10 cells....
Impairments in the differentiation and migratory capacity of epidermal stem cells (ESCs) are pivotal factors contributing to delayed wound healing. High mobility group box1 (HMGB1) has recently emerged as a potential target for tissue repair. Therefore, we aimed investigate role molecular mechanisms HMGB1 ESCs during wound-healing process.