A5091079962- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Cleft Lip and Palate Research
- Cancer-related molecular mechanisms research
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- RNA modifications and cancer
- Reconstructive Facial Surgery Techniques
- Tracheal and airway disorders
- Salivary Gland Disorders and Functions
- Bone Tumor Diagnosis and Treatments
- Ear and Head Tumors
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Facial Trauma and Fracture Management
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Facial Nerve Paralysis Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Oral health in cancer treatment
- Immune cells in cancer
- MicroRNA in disease regulation
- Dysphagia Assessment and Management
- Ocular Surface and Contact Lens
Stomatology Hospital
2016-2025
Guiyang Medical University
2025
Affiliated Hospital of Guizhou Medical University
2025
Hospital of Stomatology, Sun Yat-sen University
2015-2024
Sun Yat-sen University
2015-2024
Key Laboratory of Guangdong Province
2018-2024
Google (United States)
2024
The University of Texas Health Science Center at Houston
2020
Fifth Affiliated Hospital of Sun Yat-sen University
2017
Chinese University of Hong Kong
2017
Abstract SARS-CoV-2 has resulted in numerous cases of Coronavirus Disease 2019 (COVID-19) worldwide. In addition to fever and respiratory symptoms, digestive symptoms also are observed some patients with COVID-19. Angiotensin-converting enzyme 2 (ACE2) was reported be the receptor for SARS-CoV-2. The aim this study comprehensively investigate that occur COVID-19 patients, potential pathogenic route infection tract organs (from oral cavity gastrointestinal tract). We investigated 48 explored...
Cancer metastasis that is resistant to conventional therapies has become a major cause of patient death. Recent reports indicate the neutrophil extracellular trap (NET) closely associated with cancer distant metastases, and cell-free DNA NETs been identified as ligand transmembrane protein CCDC25 cells, acting chemokine induce cell migration organs. In this work, we present poly(aspartic acid) based-cationic materials interfere interaction between NET-DNA CCDC25, furthermore inhibit...
Immunotherapy has been recognized as one of the most promising treatment strategies for head and neck squamous cell carcinoma (HNSCC). As a pioneering trend immunotherapy, dendritic (DC) vaccines have displayed ability to prime an immune response, while insufficient immunogenicity low lymph node (LN) targeting efficiency, resulted in unsubstantiated therapeutic efficacy clinical trials. Herein, hybrid nanovaccine (Hy-M-Exo) is developed via fusing tumor-derived exosome (TEX) membrane vesicle...
Adenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and high incidence of distant metastasis (DM). The aim this study was to evaluate predictive factors for local-regional (LR) recurrence, DM, survival in ACC. A retrospective review the medical records patients with salivary glands ACC from 1990 2015 performed. clinical parameters were assessed identify correlations development LR these patients. Among 228 who underwent surgery as definitive treatment,...
Our objective is to explore the effect of P53 on progression periodontitis by regulating macrophages differentiation both in vitro and vivo. Eighteen normal gingival tissues were collected for detecting expression infiltration immunofluorescence, real-time PCR (qPCR) western-blot. The inflammatory cytokines (TNF-α IL-6) THP-1, RAW264.7 bone marrow derived macrophage (BMDM) cells, treating with Pifithrin-α (P53 inhibitor) or Nutlin-3a activator) under lipopolysaccharide (LPS) stimulation,...
Necroptosis is a recently discovered form of programmed cell death (PCD) having necrotic-like morphology. However, its presence and potential impact with respect to head neck squamous carcinoma (HNSCC) are still unknown. The aim this study was reveal the necroptosis status clinicopathological relevance in HNSCC establish an vitro model. We first analyzed level p-MLKL, MLKL, tumor necrosis patient tissues as well their correlation features. Results showed that approximately half can be...
The crosstalk between the oral microbiome and cancer has yet to be characterized. This study recruited 218 patients for clinicopathological data analysis. Multiple types of specimens were collected from 27 16S rRNA gene sequencing, including 26 saliva, 16 swabs surface tumor tissues, adjacent normal 22 outer tissue, inner 10 lymph nodes. Clinicopathological showed that pathogenic bacteria could frequently detected in cavity patients, which was positively related diabetes, later T stage...
Although chemotherapy, targeted therapy, and antiangiogenic drugs have become the cornerstones of treatment for advanced non-small-cell carcinoma (NSCLC) in clinical practice, emergence immune checkpoint inhibitors (such as PD-1 inhibitors) recent years has also provided new options NSCLC. To explore whether combined with recombinant human endostatin chemotherapy followed by IMRT a certain curative effect We retrospectively analyzed 47 patients stage IIIB, IIIC, IV NSCLC admitted to our...
J Oral Pathol Med (2011) 40: 37–45 Background: Involvement of Notch signaling in several tumors is well known, but its role tongue squamous cell carcinoma remains poorly characterized. The purpose this study was to evaluate the roles oncogenesis carcinoma. Materials and Methods: Tumor specimens adjacent non-neoplastic tissues from 74 patients with human line Tca8113 were examined using immunohistochemistry RT-PCR determine expressions Notch1, Notch3, Jagged1, Jagged2. Results: mRNA Jagged2...