A5101573155- Inflammasome and immune disorders
- Streptococcal Infections and Treatments
- Dysphagia Assessment and Management
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Response and Inflammation
- Spinal Cord Injury Research
- RNA modifications and cancer
- Exercise and Physiological Responses
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- ATP Synthase and ATPases Research
- Alzheimer's disease research and treatments
- Dielectric properties of ceramics
- Obstructive Sleep Apnea Research
- Vitamin C and Antioxidants Research
- Pharmacological Effects and Toxicity Studies
- Autoimmune and Inflammatory Disorders Research
- Nutrition and Health in Aging
- Diabetic Foot Ulcer Assessment and Management
- Microwave Dielectric Ceramics Synthesis
- Ferroelectric and Piezoelectric Materials
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
- Gout, Hyperuricemia, Uric Acid
- Autophagy in Disease and Therapy
Huazhong University of Science and Technology
2012-2025
Tongji Hospital
2012-2025
Qingdao University
2020-2023
Affiliated Hospital of Qingdao University
2020-2023
China Earthquake Administration
2020
Intestinal barrier dysfunction is associated with the occurrence and development of sepsis. Further, aerobic glycolysis plays an essential role in inflammation cell death. This study aimed at investigating protective effect mechanism PFKFB3 inhibition on intestinal sepsis mice. Sepsis mouse models were established by cecal ligation puncture (CLP) wild-type mice Gsdmd-/- The results showed that expression 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) small intestines was...
N6-methyladenosine (m6A) plays a role in various diseases, but it has rarely been reported acute lung injury (ALI). The fat mass and obesity-associated (FTO) protein can regulate mRNA metabolism by removing m6A residues. This study aimed to examine the mechanism of demethylase FTO lipopolysaccharide (LPS)-induced ALI. Lung epithelial knockout mice knockdown/overexpression A549 cell lines were constructed evaluate effects on Bioinformatics analysis series vivo vitro assays used regulation....
Acute lung injury (ALI) has been known to be a devastating form of respiratory infection and an important contributor mortality in intensive care, due its lacking effective treatment. Inflammation, oxidative stress, pyroptosis are associated with multiple kinds inflammatory diseases such as ALI. It is commonly accepted that Gly-Pro-Ala (GPA) peptide regulates stress different diseases. Our study aimed at exploring the regulatory function protective effects GPA peptides on In current study,...
Pyroptosis plays a pivotal role in sepsis and septic shock animal studies. However, its clinical significance pathological conditions has not been well elucidated. This study aimed to evaluate the correlation between percentage of pyroptotic peripheral blood mononuclear cells (PBMCs) index investigate relationship PBMCs pyroptosis development trauma patients. prospective was conducted from October 2016 May 2017 comprehensive center. Sixty patients 10 healthy controls were enrolled....
Pyroptosis has been known to play a vital role in the inflammation process which was induced by infection, injury, or inflammatory disease. The present study aimed at evaluating percentage of peripheral blood mononuclear cell (PBMC) pyroptosis septic patients and assessing correlation PBMC with severity mortality patients.128 trauma-induced sepsis were enrolled this prospective cohort study. Blood samples collected, measured flow cytometry within 24 hours after diagnosed.Percentage...
ABSTRACT Background: Sepsis commonly leads to skeletal muscle atrophy, characterized by substantial weakness and degeneration, ultimately contributing an adverse prognosis. Studies have shown that programmed cell death is important factor in the progression of loss sepsis. However, precise role mechanism pyroptosis atrophy are not yet fully comprehended. Therefore, we aimed examine action effector protein GSDMD recognized cellular mouse models Methods: The levels N-GSDMD were evaluated 2, 4,...
Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, which life-threatening condition resulting from dysregulated host response to infection. Pyroptosis, pro-inflammatory mode lytic cell death mediated by GSDMD (Gasdermin D), involved in the pathogenesis SAE. While autophagy has been extensively studied SAE, role nuclear not yet well understood. In this study, we aimed investigate involvement pyroptosis and neural We analyzed CLP (cecal ligation puncture)-induced SAE...
Repetitive transcranial magnetic stimulation (rTMS) is an effective non-invasive cortical technique in the treatment of neuropathic pain. As a new rTMS technique, intermittent theta burst (iTBS) also at relieving We aimed to establish pain-relieving effectiveness different modalities on The study was conducted individuals with spinal cord injury (SCI) and rTMS.Thirty-seven SCI were randomly allocated three groups, which "iTBS" group received iTBS, "rTMS" 10 Hz rTMS, "iTBS + rTMS" iTBS...
Background: Skeletal muscle wasting is a common complication of sepsis, leading to severe weakness, atrophy, and poor prognosis. Studies have shown that programmed cell death critical mechanism in sepsis-associated muscular atrophy. Therefore, we aimed study the role pyroptosis executive protein GSDMD established mouse models sepsis.Methods: Sepsis was by cecal ligation puncture Gsdmd knockout wild-type mice. The atrophy gastrocnemius tibialis anterior evaluated model sepsis. morphology,...
Objective To discuss the expression of Aldose reductase in acute spinal cord injury and effect inhibitor on cell apoptosis.Methods One hundred fifty SD adult rats were randomly assigned to sham group (n =50),acute =50 ),Aldose (Epalrestat Tablets) =50),each is divided into five sub- groups(6,12,24,48,72 h sub-groups).In group,only laminectomy was applied; In SCI ARI group,the model made by Allen' s method.The pathological changes injured observed with hematoxylin eosin staining.The aldose...
Objective To observe the effect of neuromuscular electrical stimulation (NMES) at different intensities on functional swallowing and velocity hyolaryngeal excursion in post-stroke dysphagia. Methods Thirty stroke survivors with dysphagia were randomly divided into a control group, an NMES group intensive each 10. All 3 groups received conventional training, while patients also 30~80 Hz intensity ≤25 mA once day those it twice day. Before, as well 2 4 weeks after treatment, video...
The paper involves the application of surface geological method for regional site classification in Beijing. Geological maps are collected through GIS to create a relationship between factors and index US NEHRP code. First, is obtained, based on conversion, given by Chinese researchers, China’s Code Seismic Design Buildings (GB50011-2010), results Beijing obtained (GB50011-2010). Finally, borehole data Beijing, map verified analyzed.