A5017350342- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Circadian rhythm and melatonin
- Gout, Hyperuricemia, Uric Acid
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Sleep and Wakefulness Research
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
Huazhong University of Science and Technology
2020-2023
Tongji Hospital
2020-2023
Abstract Aims The involvement of pyroptosis in ischemic stroke remains to be established. Therefore, we used the specific inhibitor Vx765 as an experimental intervention target a murine model stroke. Methods A total 564 C57BL/6 mice were subjected photothrombotic procedures and treated via gavage with at 1‐hour post‐ischemia. We subsequently assessed expression Gasdermin D (GSDMD), inflammasomes, caspase‐1, interleukin‐1β (IL‐1β) using immunofluorescence (IF) Western blot (WB) analyses. also...
Abstract Depression is a common chronic psychiatric illness, which resistant to medical treatments. While melatonin may alleviate certain depression symptoms, evidence for its efficacy against core symptoms lacking. Here, we tested mechanism whereby rescues the behavioral outcomes of unpredictable mild stress (CUMS) mouse model depression. CUMS mice showed depressive behaviors tail suspension, open field behavior, and sucrose preference test, cognitive dysfunction in Morris water maze....
Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, which life-threatening condition resulting from dysregulated host response to infection. Pyroptosis, pro-inflammatory mode lytic cell death mediated by GSDMD (Gasdermin D), involved in the pathogenesis SAE. While autophagy has been extensively studied SAE, role nuclear not yet well understood. In this study, we aimed investigate involvement pyroptosis and neural We analyzed CLP (cecal ligation puncture)-induced SAE...
Abstract Background Mechanisms underlying cognitive dysfunction following traumatic brain injury (TBI) partially due to abnormal amyloid processor protein (APP) cleavage and neural hyperactivity. Binding of the extension domain APP (ExD17) GABAbR1 receptor results in reduced activity, which might play a role mechanisms caused by TBI. Methods Stretch‐induced was utilized establish cell model HT22 cells. The TBI created striking exposed tissue with free‐falling weight. Topical or...