A5085067912- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune Response and Inflammation
- Venous Thromboembolism Diagnosis and Management
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Immunotherapy and Immune Responses
- interferon and immune responses
- Traumatic Brain Injury Research
- Cancer Immunotherapy and Biomarkers
- Atherosclerosis and Cardiovascular Diseases
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- Functional Brain Connectivity Studies
- Central Venous Catheters and Hemodialysis
- Peroxisome Proliferator-Activated Receptors
- COVID-19 Clinical Research Studies
- Spine and Intervertebral Disc Pathology
- Advanced Neuroimaging Techniques and Applications
- Circular RNAs in diseases
Nanfang Hospital
2019-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Southern Medical University
2019-2025
Sun Yat-sen University
2022-2025
Sun Yat-sen University Cancer Center
2024-2025
Wuhan No.1 Hospital
2023-2025
West China Medical Center of Sichuan University
2025
Hainan Medical University
2025
Zunyi Medical University
2022-2025
BACKGROUNDThe coronavirus disease 2019 (COVID-19) rapidly progressed to a global pandemic. Although some patients totally recover from COVID-19 pneumonia, the disease's long-term effects on brain still need be explored.METHODSWe recruited 51 with 2 subtypes of (19 mild and 32 severe) no specific neurological manifestations at acute stage obvious lesions conventional MRI 3 months after discharge. Changes in gray matter morphometry, cerebral blood flow (CBF), white (WM) microstructure were...
Summary Background The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in a cluster disease 2019 (COVID-19). We reported the clinical characteristics COVID-19 patients with distress (ARDS), and further investigated treatment progression ARDS COVID-19. Methods This study enrolled 109 admitted to Central Hospital Wuhan, designated hospital China, from January February 1, 2020. Patients were followed up 12, data collected electronic medical records. differences...
ABSTRACT Parkinson's disease (PD) biomarkers are needed to enhance therapeutics research and understand PD pathogenesis. Methods that simultaneously measure hundreds of small molecular‐weight compounds—metabolomic analysis–“fingerprint” disease‐specific alterations in individual compounds or metabolic pathways. Beyond a nontargeted search for biomarkers, we hypothesized cerebrospinal fluid would show increased formation the excitotoxin 3‐hydroxykynurenine diminished concentration antioxidant...
By using a torsion pendulum and rotating eightfold symmetric attractor with dual modulation of both the interested signal gravitational calibration signal, new test inverse-square law at separations down to $295\text{ }\text{ }\ensuremath{\mu}\mathrm{m}$ is presented. A dual-compensation design by adding masses on was adopted realize null experiment. The experimental result shows that, 95% confidence level, holds ($|\ensuremath{\alpha}|\ensuremath{\le}1$) length scale...
Abstract Aims The involvement of pyroptosis in ischemic stroke remains to be established. Therefore, we used the specific inhibitor Vx765 as an experimental intervention target a murine model stroke. Methods A total 564 C57BL/6 mice were subjected photothrombotic procedures and treated via gavage with at 1‐hour post‐ischemia. We subsequently assessed expression Gasdermin D (GSDMD), inflammasomes, caspase‐1, interleukin‐1β (IL‐1β) using immunofluorescence (IF) Western blot (WB) analyses. also...
Background: Biomarkers to prognosticate the outcomes and guide treatment of patients with severe coronavirus disease 2019 (COVID-19) are currently required. We aimed investigate whether dynamic variation cytokines was associated survival admitted intensive care unit (ICU).Methods: A retrospective study performed on 40 COVID-19 ICU in Wuhan, China. Demographic, clinical, laboratory variables were collected, serum kinetically assessed. multivariable-adjusted generalized linear regression model...
Brassaiopsis glomerulata (Blum) Regel (B.glomerulata) is recognized as a traditional Chinese medicine (TCM) primarily used for promoting blood circulation and removing stasis. It frequently utilized in the treatment of injuries resulting from falls bumps.
To develop and validate a risk prediction model for predicting the of Peripherally Inserted Central Catheter-Related venous thrombosis (PICC-RVT) in cancer patients with PICCs. A prospective cohort study 281 PICCs was conducted from April 2023 to January 2024. Data on patient-, laboratory- catheter-related factors were collected day catheterization. Patients investigated PICC-RVT by Doppler sonography presence signs symptoms. Univariate multivariate regression analyses used identify...
Colony stimulating factor-1 (CSF-1) is the primary regulator of mononuclear phagocytic lineage acting through its transmembrane tyrosine kinase receptor, CSF-1R, that product c-fms proto-oncogene. Null mutations in either ligand or receptor genes result a severe osteopetrosis as well number other phenotypes, including reproductive defects and perturbations organ development. The CSF-1R also expressed oocytes, myoblast progenitors, decidual, trophoblastic cells. To distinguish cell type...
Hydroxysafflor yellow A (HSYA) is a major active component of pigment extracted from safflowers; this compound possesses potent neuroprotective effects both in vitro and vivo. However, underlying mechanism HSYA not fully elucidated. The present study investigated the protective rat spinal cord compression injury model related mechanisms involved. Sprague–Dawley rats were divided as Sham, Control, groups (n = 30 per group). Spinal (SCI) was induced by application vascular clips (force 50 g, 1...
Abstract Background We used multimodal compositional magnetic resonance imaging (MRI) techniques, combined with clinical outcomes, to differentiate the alternations of composition in repair cartilage allogeneic human adipose-derived mesenchymal progenitor cells (haMPCs) knee osteoarthritis (KOA) patients. Methods Eighteen patients participated a phase I/IIa trial. All were divided randomly into three groups intra-articular injections haMPCs: low-dose (1.0 × 10 7 cells), mid-dose (2.0 ), and...
Abstract Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of cells (pDC). BPDCN occurs at least three times more frequently in men than women, but the reasons for this sex bias are unknown. Here, studying genomics primary and modeling disease-associated mutations, we link acquired alterations RNA splicing to abnormal pDC development inflammatory response through Toll-like receptors. Loss-of-function mutations ZRSR2, X chromosome gene encoding a factor, enriched...
To explore the protective roles of Astragalus polysaccharide (APS) on acute renal injury (AKI) induced by sepsis.Firstly, an animal model sepsis-induced AKI was established injecting lipopolysaccharide (LPS) into mice. The mice were pretreated with intraperitoneal injection 1, 3, and 5 mg/(kg·d) APS for 3 consecutive days. severity kidney then scored histopathological analysis, concentrations serum urea nitrogen (BUN) creatinine (SCr) levels tumor necrosis factor α (TNF-α) interleukin-1β...
Diffuse axonal injury (DAI) is the predominant effect of severe traumatic brain and contributes significantly to neurological deficits. However, it difficult diagnose or characterize non-invasively with conventional imaging. Our study provides significant validation a visual statistical diffusion tensor imaging (DTI) technique as compared pathological electron microscopic in rat DAI model at multiple predilection sites time points following trauma. Two DTI parameters, fractional anisotropy...
Panax ginseng is one of the most popular herbal remedies. Ginsenosides, major bioactive constituents in P. , have shown good antidiabetic action, but precise mechanism was not fully understood. Glucagon-like peptide-1 (GLP1) considered to be an important incretin that can regulate glucose homeostasis gastrointestinal tract after meals. The aim this study investigate whether total saponins (GTS) exerts its effects via modulating GLP1 release. Ginsenoside Rb1 (Rb1), abundant constituent GTS,...
To investigate the incidence and risk factors for peripherally inserted central venous catheters-related upper extremity thrombosis in patients with cancer.With widespread use of catheters, cancer leads to increasing morbidity mortality. It is very important further explore thrombosis.Consecutive who were scheduled receive between September 2009 May 2012, prospectively studied our centre. They investigated by Doppler sonography three times a day within 30 days after catheter insertion....
MicroRNA-146a (miR-146a) acts as a pivotal regulatory molecule in immune response and various diseases, such carcinoma autoimmune diseases. Growing evidences have demonstrated the association of miR-146a gene single-nucleotide polymorphisms (SNPs) with risk several but no genetic relevance studies to sepsis been reported by now. Our study has analyzed two functional SNPs rs2910164 G/C rs57095329 A/G Chinese Han population (226 cases; 206 healthy controls). results indicated higher prevalence...
HLA-DRB1 is a sarcoidosis risk gene, and the *03:01 allele strongly associated with disease resolution in European cases. Whereas variation susceptibility African Americans, DRB1 alleles are not as well defined, associations have been studied. Associations between genotyped imputed susceptibility/resolution were evaluated sample of 1,277 African-American patients 1,467 control subjects. In silico binding assays performed to assess functional significance alleles. Increased was *12:01 (odds...