A5101533263- Spectroscopy Techniques in Biomedical and Chemical Research
- Digital Holography and Microscopy
- Cell Image Analysis Techniques
- Cellular Mechanics and Interactions
- Molecular Biology Techniques and Applications
- Identification and Quantification in Food
- Metabolomics and Mass Spectrometry Studies
- Analytical chemistry methods development
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Spectroscopy and Chemometric Analyses
- Gut microbiota and health
- Optical measurement and interference techniques
- Laser-induced spectroscopy and plasma
- Nutrition, Genetics, and Disease
- Aldose Reductase and Taurine
- Adolescent and Pediatric Healthcare
- Microfluidic and Bio-sensing Technologies
- Bipolar Disorder and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- Heavy Metals in Plants
Johns Hopkins University
2019-2023
University of Baltimore
2023
First Affiliated Hospital of Henan University of Science and Technology
2016
Huazhong University of Science and Technology
2012
Tongji Hospital
2012
In this study, we explored the relation between metastatic states vs capacity of confined migration, amoeboid transition, and cellular stiffness. We compared across an isogenic panel human breast cancer cells derived from MDA-MB-231 cells. It was observed that after lung metastasis have fastest migration lowest stiffness, with a significantly higher to transition into mode. Our findings illustrate is selective process favoring motile softer Moreover, observation circulating tumor resemble...
The accurate analytical characterization of metastatic phenotype at primary tumor diagnosis and its evolution with time are critical for controlling progression cancer.Here, we report a label-free optical strategy using Raman spectroscopy machine learning to identify distinct phenotypes observed in tumors formed by isogenic murine breast cancer cell lines progressively increasing propensities.Methods: We employed the 4T1 panel cells grow varying potential acquired spectra fiber probe-based...
Delineating the molecular and morphological changes that cancer cells undergo in response to extracellular stimuli is crucial for identifying factors promote tumor progression. Label-free optical imaging offers a potentially promising route retrieving such single-cell information by generating detailed visualization of morphology determining alterations biomolecular composition. The potential nonperturbative morphomolecular microscopy analyzing microbiota–cancer cell interactions has been...
Lithium is especially taken as a maintenance medication for Bipolar Disorder. In women with bipolar disorder, lithium often effective during postpartum period, but breast-feeding medicated mothers controversial because of harmful effects her child. At present, the biological mechanisms are not well-understood, affecting its usage and overall health implications.We developed rat model at human therapeutic levels to study exposure through breast-milk on pups' thyroid function. Novel laser...
Surface modification with oligonucleotides renders gold nanoparticles to endocytose through very different pathways as compared unmodified ones. Such oligonucleotide-modified (OGNs) have been exploited effective nanocarriers for gene regulation therapies. Notably, in an effort reduce overall dosage and provide safer transition the clinic, cooperative systems composed of two or more discrete nanomaterials recently proposed alternative intrinsically multifunctional nanoparticles. Yet, our...
Abstract Background: 41.9% of adult US population is obese and every 5-unit BMI increase associated with 12 percent in breast cancer risk; it an independent predictor poor outcomes cancer. Microbiome has emerged as a central regulator obesity we recently discovered that microbes can not only potentiate growth metastasis but also affect therapeutic response. We showed weight-loss by Diet/Exercise/Behavioral intervention (POWER-remote trial) exerts favorable effects. Here, examine molecular...
Objective To discuss the expression of Aldose reductase in acute spinal cord injury and effect inhibitor on cell apoptosis.Methods One hundred fifty SD adult rats were randomly assigned to sham group (n =50),acute =50 ),Aldose (Epalrestat Tablets) =50),each is divided into five sub- groups(6,12,24,48,72 h sub-groups).In group,only laminectomy was applied; In SCI ARI group,the model made by Allen' s method.The pathological changes injured observed with hematoxylin eosin staining.The aldose...
Here, we develop a deep learning-powered 3D virtual fluorescence staining approach from label-free quantitative phase images to accurately discriminate between adipocyte cell structures.
Abstract The accurate analytical characterization of metastatic phenotype at primary tumor diagnosis and its evolution with time are critical for controlling progression cancer. Here, we report a label-free optical strategy using Raman spectroscopy machine learning to identify distinct phenotypes observed in tumors formed by isogenic murine breast cancer cell lines progressively increasing propensities. Our spectra-based random forest analysis provided evidence that models built on spectral...