A5078476249- Spectroscopy Techniques in Biomedical and Chemical Research
- Hearing Loss and Rehabilitation
- Neural dynamics and brain function
- Hearing, Cochlea, Tinnitus, Genetics
- Optical Imaging and Spectroscopy Techniques
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Photoacoustic and Ultrasonic Imaging
- Visual perception and processing mechanisms
- Vestibular and auditory disorders
- Spectroscopy and Chemometric Analyses
- Noise Effects and Management
- Laser-induced spectroscopy and plasma
- Neuroscience and Music Perception
- Retinal Development and Disorders
- Dental Erosion and Treatment
- Multisensory perception and integration
- Erythrocyte Function and Pathophysiology
- Dental Implant Techniques and Outcomes
- Cervical Cancer and HPV Research
- Analytical chemistry methods development
- Biochemical Analysis and Sensing Techniques
- Mercury impact and mitigation studies
City University of Hong Kong
2016-2025
Google (United States)
2021
University of Hong Kong
2010-2018
Kowloon Hospital
2018
City University of Seattle
2018
Hong Kong University of Science and Technology
2014
Massachusetts Institute of Technology
2006-2013
Chinese University of Hong Kong
2010
Herein, we reveal that the cytotoxicity mechanism of graphene oxide is synergy between membrane and oxidative stress towards biofilm forming bacteria.
We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This provides maps tissue biochemistry and morphology, making it potentially powerful surveillance tool objective detection. describe the design, construction, calibration, first clinical application this new system. demonstrate its accuracy using physical models. validate diagnostic ability on resected colon adenoma, feasibility in vivo oral cavity.
Alzheimer's disease (AD) is characterized in the late stages by amyloid-β (Aβ) plaques and neurofibrillary tangles. Nevertheless, recent evidence has indicated that early changes cerebral connectivity could compromise cognitive functions even before appearance of classical neuropathological features. Diffusion tensor imaging (DTI), resting-state functional magnetic resonance (rs-fMRI) volumetry were performed triple transgenic mouse model AD (3xTg-AD) at 2 months age, prior to development...
Background The superior colliculus (SC) and lateral geniculate nucleus (LGN) are important subcortical structures for vision. Much of our understanding vision was obtained using invasive small field view (FOV) techniques. In this study, we use non-invasive, large FOV blood oxygenation level-dependent (BOLD) fMRI to measure the SC LGN's response temporal dynamics following short duration (1 s) visual stimulation. Methodology/Principal Findings Experiments performed at 7 tesla on Sprague...
Model-based light scattering spectroscopy (LSS) seemed a promising technique for in-vivo diagnosis of dysplasia in multiple organs. In the studies, residual spectrum, difference between observed and modeled diffuse reflectance spectra, was attributed to single elastic from epithelial nuclei, diagnostic information due nuclear changes extracted it. We show that this picture is incorrect. The actual signal arising nuclei much smaller than previously computed does not have wavelength dependence...
Subcritical calvarial defects heal spontaneously and optical methods can study the healing without mechanically perturbing bone. In this study, 1mm were created on skulls (in vivo) of Sprague-Dawley rats (n = 14). After 7 7) 14 days healing, subjects sacrificed additional similarly (control). Raman spectroscopy (785nm) was performed at two time points defect types. Spectra quantified by mineral/matrix ratio, carbonate/phosphate ratio crystallinity. Mineral/matrix in vivo is lower than that...
The thyroid is an important hormone regulation organ. Laser induced breakdown spectroscopy (LIBS) developed to assess iodine and other essential elements in the (of rats). Subjects are administered 0.05% water for 0, 6, 12 days before extracted. Pronounced iodine, sodium, calcium, potassium emissions observed at approximately 746, 589, 395/422, 766/770 nm, respectively. Iodine emission surprisingly highest 0 day subjects, lowest after 6 days, recovers by days. This follows Wolff-Chaikoff...
Abstract One major challenge in echo planar imaging‐based functional MRI (fMRI) is the susceptibility‐induced image distortion. In this study, a new cerebral blood volume‐weighted fMRI technique using distortion‐free balanced steady‐state free precession (bSSFP) sequence was proposed and its feasibility investigated rat brain at 7 Tesla. After administration of intravascular susceptibility contrast agent (monocrystalline iron oxide nanoparticle [MION] 15 mg/kg), unilateral visual stimulation...
Breast feeding provides considerable benefits to the infant and mother.However, a lithium-based psychiatric medication may cause side effects in child.Using laser induced breakdown spectroscopy (LIBS), trace lithium levels were observed breast milk of lactating rats administered with treatment postpartum.Subsequently, mammary glands female analyzed using LIBS, energy dispersive X-ray fluorescence spectroscopy, inductively coupled plasma mass spectrometry.Key biological elements iron,...
Lithium-based medications are used successfully to treat many mental disorders, including bipolar disorder and Alzheimer's disease.However, the therapeutic mechanisms not well characterized due limitations in detecting lithium organs cells.This limits ability improve lithium-based treatments.To address this need, laser-induced breakdown spectroscopy (LIBS) is developed for rapid situ detection of biological tissues.Pronounced emissions observed at 670.7nm from rat thyroid, salivary, mammary...