A5103223948- Genetics and Neurodevelopmental Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Neuroscience and Neuropharmacology Research
- Autism Spectrum Disorder Research
- Vestibular and auditory disorders
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Congenital heart defects research
- Neural dynamics and brain function
- Endoplasmic Reticulum Stress and Disease
- Neuroscience and Neural Engineering
- RNA regulation and disease
- CRISPR and Genetic Engineering
- Nanocomposite Films for Food Packaging
- Cardiac Arrest and Resuscitation
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neurobiology and Insect Physiology Research
- Cholinesterase and Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Noise Effects and Management
- Multisensory perception and integration
- EEG and Brain-Computer Interfaces
- Neuroscience of respiration and sleep
University of Illinois Urbana-Champaign
2021-2025
University of California, San Francisco
2024
Women & Children's Hospital of Buffalo
2017-2021
University at Buffalo, State University of New York
2014-2020
Massachusetts Institute of Technology
1975-2013
Howard Hughes Medical Institute
2007-2011
Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability, resulting from mutation in the FMR1 gene subsequent loss its protein product FMRP. Despite this simple genetic origin, FXS phenotypically complex disorder with range physical neurocognitive disruptions. While numerous molecular cellular pathways are affected by FMRP loss, there growing evidence that circuit hyperexcitability may be common convergence point can account for many wide-ranging phenotypes...
Inhibitors of phosphodiesterase-4 (PDE4) have beneficial effects on memory in preclinical and clinical studies. Development these drugs has stalled due to dose-limiting side nausea emesis. While use subtype-selective inhibitors (i.e., for PDE4A, B, or D) could overcome this issue, conservation the catalytic region, which classical bind, limits approach. The present study examined BPN14770, an allosteric inhibitor PDE4D, binds a primate-specific, N-terminal region. In mice engineered express...
Synaptic protein synthesis is essential for modification of the brain by experience and aberrant in several genetically defined disorders, notably fragile X (FX), a heritable cause autism intellectual disability. Neural activity directs local via activation metabotropic glutamate receptor 5 (mGlu5), yet how mGlu5 couples to intracellular signaling pathways that regulate mRNA translation poorly understood. Here, we provide evidence β-arrestin2 mediates mGlu5-stimulated hippocampus show...
Fragile X Syndrome (FXS), the most common inherited form of intellectual disability, is caused by loss fragile mental retardation protein (FMRP). FMRP a negative regulator local mRNA translation downstream group 1 metabotropic glutamate receptor (Gp1 mGluR) activation. In absence there excessive mGluR-dependent synthesis, resulting in exaggerated long-term synaptic depression (LTD) area CA1 hippocampus. Understanding disease pathophysiology critical for development therapies FXS and question...
Tinnitus and hyperacusis are common potentially serious hearing disorders associated with noise-, age- or drug-induced loss. Accumulating evidence suggests that tinnitus linked to excessive neural activity in a distributed brain network not only includes the central auditory pathway, but also regions involved arousal, emotion, stress motor control. Here we examine electrophysiological changes two novel non-auditory areas implicated hyperacusis: caudal pontine reticular nucleus (PnC),...
Significance Achieving abstinence is difficult for individuals with cocaine use disorder but the greater challenge avoiding relapse. Relapse vulnerability provoked by exposure to drug-associated cues that evoke drug craving. Cue-induced craving persists during prolonged and mediated neuroadaptations in brain. We found activin A increased dorsal hippocampus (DH) prolonged, not acute, regulates phosphorylation of NMDA receptor subunit GluN2B. Both GluN2B-containing receptors DH regulate...
ABSTRACT Atypical sensory processing, particularly in the auditory domain, is one of most common and quality-of-life affecting symptoms seen autism spectrum disorders (ASD). Fragile X Syndrome (FXS) leading inherited cause ASD a majority FXS individuals present with processing alterations. While hypersensitivity phenotype observed Fmr1 KO rodent models, it important to consider other coding impairments that could contribute sound difficulties disrupted language comprehension FXS. We have...
Fragile X (FX) syndrome is one of the leading inherited causes autism spectrum disorder (ASD). A majority FX and ASD patients exhibit sensory hypersensitivity, including auditory hypersensitivity or hyperacusis, a condition in which everyday sounds are perceived as much louder than normal. Auditory processing deficits also afford opportunity to develop objective quantifiable outcome measures that likely translate between humans animal models due well-conserved nature system well-developed...
Electrophysiological and imaging studies from humans suggest that the phantom sound of tinnitus is associated with abnormal thalamocortical neural oscillations (dysrhythmia) enhanced gamma band activity in auditory cortex. However, these models have seldom been tested animal where it possible to simultaneously assess oscillatory within between thalamus To explore this issue, we used multichannel electrodes examine behavior local field potentials recorded rat medial geniculate body (MBG)...
Point-of-care electroencephalography (EEG) devices can be rapidly applied and do not require specialized technologists, creating new opportunities to use EEG during prehospital care. We evaluated the feasibility of point-of-care ambulance transport for 911 calls.
The short range atomic arrangements in crystalline chitin, chitosan and amorphous films are shown to be similar that the fundamental rings chains retained all of these structures. interchain bonding differs, however, is weakest strongest chitin.
Abstract Fragile X (FX) syndrome is one of the leading inherited causes autism spectrum disorder (ASD). A majority FX and ASD patients exhibit sensory hypersensitivity, including auditory hypersensitivity or hyperacusis, a condition in which everyday sounds are perceived as much louder than normal. Auditory processing deficits also afford opportunity to develop objective quantifiable outcome measures that likely translate between humans animal models due well-conserved nature system...