A5037632443- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Behavioral and Psychological Studies
- Cannabis and Cannabinoid Research
- Animal Behavior and Welfare Studies
- Protein Degradation and Inhibitors
- Nerve injury and regeneration
- Ubiquitin and proteasome pathways
- Neural and Behavioral Psychology Studies
- Zebrafish Biomedical Research Applications
- Genetics and Neurodevelopmental Disorders
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Rabbits: Nutrition, Reproduction, Health
- Cancer-related gene regulation
- PARP inhibition in cancer therapy
- Pancreatic function and diabetes
- Chromatin Remodeling and Cancer
California State University, Bakersfield
2017-2024
University at Buffalo, State University of New York
2013-2023
Institute of Pharmacology
2014
Buffalo State University
2013
An imbalance in molecular signaling cascades and transcriptional regulation nucleus accumbens (NAc) medium spiny neuron (MSN) subtypes, those enriched dopamine D1 versus D2 receptors, is implicated the behavioral responses to psychostimulants. To provide further insight into mechanisms occurring MSN subtypes by cocaine, we examined transcription factor early growth response 3 (Egr3). We evaluated Egr3 because it a target of critical cocaine-mediated pathways Egr3-binding sites are found on...
Exposure to psychostimulants results in structural and synaptic plasticity striatal medium spiny neurons (MSNs). These cellular adaptations arise from alterations genes that are highly implicated the rearrangement of actin-cytoskeleton, such as T-lymphoma invasion metastasis 1 (Tiam1). Previous studies have demonstrated a crucial role for dopamine receptor (D1)-containing MSNs mediating psychostimulant induced changes. D1-MSNs nucleus accumbens (NAc) positively regulate drug seeking, reward,...
Many of the long-term effects cocaine on brain's reward circuitry have been shown to be mediated by alterations in gene expression. Several chromatin modifications, including histone acetylation and methylation, implicated this regulation, but effect other modifications remains poorly understood. Poly(ADP-ribose) polymerase-1 (PARP-1), a ubiquitous abundant nuclear protein, catalyzes synthesis negatively charged polymer called poly(ADP-ribose) or PAR histones substrate proteins forms...
Repeated cocaine exposure regulates transcriptional regulation within the nucleus accumbens (NAc), and epigenetic mechanisms-such as histone acetylation methylation on Lys residues-have been linked to these lasting actions of cocaine. In contrast methylation, role Arg (R) remains underexplored in addiction models. Here we show that protein-R-methyltransferase-6 (PRMT6) its associated mark, asymmetric dimethylation R2 H3 (H3R2me2a), are decreased NAc mice rats after repeated exposure,...
ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models several psychiatric disorders. Here, we demonstrate that Baz1b , an accessory subunit ISWI family complexes, is upregulated nucleus accumbens (NAc), a key brain reward region, both chronic cocaine-treated mice and resilient to social defeat stress. In contrast, no seen susceptible this Viral-mediated overexpression along with its associated Smarca5 mouse NAc...
Addictive behaviors, including relapse, are thought to depend in part on long-lasting drug-induced adaptations dendritic spine signaling and morphology the nucleus accumbens (NAc). While influence of activity-dependent actin remodeling these phenomena has been studied extensively, role microtubules associated proteins remains poorly understood. We report that pharmacological inhibition microtubule polymerization NAc inhibited locomotor sensitization cocaine contextual reward learning. then...
Significance Achieving abstinence is difficult for individuals with cocaine use disorder but the greater challenge avoiding relapse. Relapse vulnerability provoked by exposure to drug-associated cues that evoke drug craving. Cue-induced craving persists during prolonged and mediated neuroadaptations in brain. We found activin A increased dorsal hippocampus (DH) prolonged, not acute, regulates phosphorylation of NMDA receptor subunit GluN2B. Both GluN2B-containing receptors DH regulate...
Abstract Organisms must regulate their behavior flexibly in the face of environmental challenges. Failure can lead to a host maladaptive behavioral traits associated with range neuropsychiatric disorders, including attention deficit hyperactivity disorder, autism, and substance use disorders. This dysregulation is influenced by genetic factors. For example, enrichment produces beneficial neurobehavioral effects animal models such The present study determined on measures related regulation...
Abstract Persistent transcriptional and morphological events in the nucleus accumbens (NAc) other brain reward regions contribute to long-lasting behavioral adaptations that characterize drug addiction. Opiate exposure reduces density of dendritic spines on medium spiny neurons NAc; however, underlying cellular mediating this remain unknown. We show heroin self-administration negatively regulates actin-binding protein drebrin NAc. Using virus-mediated gene transfer, we overexpression NAc is...
Drug addiction is characterized by compulsive drug-taking behaviors and a high propensity to relapse following drug cessation. craving seeking can increase during period of abstinence, but this phenomenon not observed in drug-induced reinstatement models. To investigate the effect withdrawal on cocaine relapse, rats were exposed extended-access self-administration subjected either 1 or 30 d withdrawal. When tested 12 h unlimited access (binge), duration did influence intake. However, using...
Proteasomal-regulated chromatin remodeler mediates cocaine relapse during abstinence.
Abstract Drug addiction is a long-lasting disease characterized by compulsive drug intake mediated in part neuronal and biological adaptations key brain areas, such as the nucleus accumbens (NAc). While we previously demonstrated involvement of activin 2a receptor taking, role its ligand, A, cocaine relapse unknown. Activin A levels NAc were assessed via ELISA immunohistochemistry (in neurons, astrocytes, microglia) following binge paradigm. Cocaine exposure significantly increased animals...