A5036467183- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Cannabis and Cannabinoid Research
- Bone and Dental Protein Studies
- Nerve injury and regeneration
- Neuroendocrine regulation and behavior
- Immune cells in cancer
- Genomics and Chromatin Dynamics
- Memory and Neural Mechanisms
- Histone Deacetylase Inhibitors Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer-related gene regulation
- Pancreatitis Pathology and Treatment
- Bone Metabolism and Diseases
- Nicotinic Acetylcholine Receptors Study
- Nuclear Receptors and Signaling
- RNA Interference and Gene Delivery
- Protein Degradation and Inhibitors
- Neural dynamics and brain function
- Zebrafish Biomedical Research Applications
Allen Institute for Brain Science
2012-2018
Icahn School of Medicine at Mount Sinai
2010-2017
Henry Ford Hospital
2007-2015
Spectrum Health
2014
BDNF, Dopamine, and Cocaine Reward The nucleus accumbens plays a crucial role in mediating the rewarding effects of drugs abuse. Different subpopulations projection neurons exhibit balanced but antagonistic influences on their downstream outputs behaviors. However, roles regulating reward behaviors remains unclear. Lobo et al. (p. 385 ) evaluated two subtypes neurons, those expressing dopamine D1 versus D2 receptors, cocaine reward. Deleting TrkB, receptor for brain-derived neurotrophic...
Cocaine-induced alterations in gene expression cause changes neuronal morphology and behavior that may underlie cocaine addiction. In mice, we identified an essential role for histone 3 lysine 9 (H3K9) dimethylation the dimethyltransferase G9a cocaine-induced structural behavioral plasticity. Repeated administration reduced global levels of H3K9 nucleus accumbens. This reduction methylation was mediated through repression this brain region, which regulated by transcription factor DeltaFosB....
The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, stress. However, very few studies have examined the degree ΔFosB induction two striatal medium spiny neuron (MSN) subtypes. We make use fluorescent reporter BAC transgenic mice to evaluate dopamine receptor 1 (D1) enriched 2 (D2) MSNs ventral striatum, nucleus accumbens (NAc) shell core, dorsal (dStr) after exposure abuse...
Regulating Opioid Responses Different drugs of abuse are thought to highjack similar reward systems in the brain using common mechanisms. However, Koo et al. (p. 124 ) now observe that some neural mechanisms regulate opiate can be both different and even opposite those by stimulant drugs. While knockdown brain-derived neurotrophic factor (BDNF) ventral tegmental area mice antagonized response cocaine, same manipulation strengthened potential opiates increase dopamine neuron excitability....
The molecular mechanisms underlying stress- and drug-induced neuronal adaptations are incompletely understood. One molecule implicated in such is ΔFosB, a transcription factor that accumulates the rodent nucleus accumbens (NAc), key brain reward region, response to either chronic stress or repeated exposure drugs of abuse. upstream transcriptional controlling ΔFosB induction by these environmental stimuli remain elusive. Here, we identify activity-dependent factor, serum (SRF), as novel...
The molecular mechanism underlying induction by cocaine of ΔFosB, a transcription factor important for addiction, remains unknown. Here, we demonstrate necessary role two factors, cAMP response element binding protein (CREB) and serum (SRF), in mediating this within the mouse nucleus accumbens (NAc), key brain reward region. CREB SRF are both activated NAc bind to fosB gene promoter. Using viral-mediated Cre recombinase expression single- or double-floxed mice, show that deletion factors...
Repeated cocaine exposure regulates transcriptional regulation within the nucleus accumbens (NAc), and epigenetic mechanisms-such as histone acetylation methylation on Lys residues-have been linked to these lasting actions of cocaine. In contrast methylation, role Arg (R) remains underexplored in addiction models. Here we show that protein-R-methyltransferase-6 (PRMT6) its associated mark, asymmetric dimethylation R2 H3 (H3R2me2a), are decreased NAc mice rats after repeated exposure,...
Sexual behavior in male rats is rewarding and reinforcing. However, little known about the specific cellular molecular mechanisms mediating sexual reward or reinforcing effects of on subsequent expression behavior. This study tests hypothesis that ΔFosB, stably expressed truncated form FosB, plays a critical role reinforcement experience‐induced facilitation motivation performance. experience was shown to cause ΔFosB accumulation several limbic brain regions including nucleus accumbens...
ΔFosB, a <i>Fosb</i> gene product, is induced in nucleus accumbens (NAc) and caudate–putamen (CPu) by repeated exposure to drugs of abuse such as cocaine. This induction contributes aberrant patterns expression behavioral abnormalities seen with drug exposure. Here, we assessed whether remote history cocaine rats might alter inducibility the elicited subsequent We show that prior chronic administration, followed extended withdrawal, increases NAc, evidenced greater acute ΔFosB mRNA faster...
The role of somatostatin interneurons in nucleus accumbens (NAc), a key brain reward region, remains poorly understood due to the fact that these cells account for < 1% NAc neurons. Here, we use optogenetics, electrophysiology, and RNA-sequencing characterize transcriptome functioning after repeated exposure cocaine. We find activity regulates behavioral responses cocaine, with cocaine reducing excitability Repeated also induces transcriptome-wide changes gene expression within interneurons....
ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models several psychiatric disorders. Here, we demonstrate that Baz1b , an accessory subunit ISWI family complexes, is upregulated nucleus accumbens (NAc), a key brain reward region, both chronic cocaine-treated mice and resilient to social defeat stress. In contrast, no seen susceptible this Viral-mediated overexpression along with its associated Smarca5 mouse NAc...
Abstract Both the induction of SPARC expression and loss p53 tumor suppressor gene are changes that occur early in glioma development. regulate cell survival by inverse effects on apoptotic signaling. Therefore, during formation, upregulation may cooperate with to enhance survival. This study determined whether Sparc astrocytes null for would result reduced formation increased immunogenicity an vivo xenograft brain model. In vitro , S parc ‐null resulted increase proliferation, but a...