A5014730948- Neurotransmitter Receptor Influence on Behavior
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Genetics and Neurodevelopmental Disorders
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Photoreceptor and optogenetics research
- Genetic Neurodegenerative Diseases
- Pharmacological Effects and Assays
- HIV Research and Treatment
- Histone Deacetylase Inhibitors Research
- Mesenchymal stem cell research
- Nuclear Receptors and Signaling
- Wnt/β-catenin signaling in development and cancer
- Calcium signaling and nucleotide metabolism
- Pharmacological Receptor Mechanisms and Effects
- Genetic Syndromes and Imprinting
- PARP inhibition in cancer therapy
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
PTC Therapeutics (United States)
2023
Allen Institute for Brain Science
2012-2019
Icahn School of Medicine at Mount Sinai
2010-2019
McLean Hospital
2008-2011
Harvard University
2008-2011
BDNF, Dopamine, and Cocaine Reward The nucleus accumbens plays a crucial role in mediating the rewarding effects of drugs abuse. Different subpopulations projection neurons exhibit balanced but antagonistic influences on their downstream outputs behaviors. However, roles regulating reward behaviors remains unclear. Lobo et al. (p. 385 ) evaluated two subtypes neurons, those expressing dopamine D1 versus D2 receptors, cocaine reward. Deleting TrkB, receptor for brain-derived neurotrophic...
The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, stress. However, very few studies have examined the degree ΔFosB induction two striatal medium spiny neuron (MSN) subtypes. We make use fluorescent reporter BAC transgenic mice to evaluate dopamine receptor 1 (D1) enriched 2 (D2) MSNs ventral striatum, nucleus accumbens (NAc) shell core, dorsal (dStr) after exposure abuse...
Regulating Opioid Responses Different drugs of abuse are thought to highjack similar reward systems in the brain using common mechanisms. However, Koo et al. (p. 124 ) now observe that some neural mechanisms regulate opiate can be both different and even opposite those by stimulant drugs. While knockdown brain-derived neurotrophic factor (BDNF) ventral tegmental area mice antagonized response cocaine, same manipulation strengthened potential opiates increase dopamine neuron excitability....
Dysregulation of histone modifying enzymes has been associated with numerous psychiatric disorders. Alterations in G9a (Ehmt2), a methyltransferase that catalyzes the euchromatic dimethylation H3 at lysine 9 (H3K9me2), implicated recently mediating neural and behavioral plasticity response to chronic cocaine administration. Here, we show morphine, like cocaine, decreases expression, global levels H3K9me2, mouse nucleus accumbens (NAc), key brain reward region. In contrast, other...
Many of the long-term effects cocaine on brain's reward circuitry have been shown to be mediated by alterations in gene expression. Several chromatin modifications, including histone acetylation and methylation, implicated this regulation, but effect other modifications remains poorly understood. Poly(ADP-ribose) polymerase-1 (PARP-1), a ubiquitous abundant nuclear protein, catalyzes synthesis negatively charged polymer called poly(ADP-ribose) or PAR histones substrate proteins forms...
Repeated cocaine exposure regulates transcriptional regulation within the nucleus accumbens (NAc), and epigenetic mechanisms-such as histone acetylation methylation on Lys residues-have been linked to these lasting actions of cocaine. In contrast methylation, role Arg (R) remains underexplored in addiction models. Here we show that protein-R-methyltransferase-6 (PRMT6) its associated mark, asymmetric dimethylation R2 H3 (H3R2me2a), are decreased NAc mice rats after repeated exposure,...
ΔFosB, a <i>Fosb</i> gene product, is induced in nucleus accumbens (NAc) and caudate–putamen (CPu) by repeated exposure to drugs of abuse such as cocaine. This induction contributes aberrant patterns expression behavioral abnormalities seen with drug exposure. Here, we assessed whether remote history cocaine rats might alter inducibility the elicited subsequent We show that prior chronic administration, followed extended withdrawal, increases NAc, evidenced greater acute ΔFosB mRNA faster...
ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models several psychiatric disorders. Here, we demonstrate that Baz1b , an accessory subunit ISWI family complexes, is upregulated nucleus accumbens (NAc), a key brain reward region, both chronic cocaine-treated mice and resilient to social defeat stress. In contrast, no seen susceptible this Viral-mediated overexpression along with its associated Smarca5 mouse NAc...
Addictive behaviors, including relapse, are thought to depend in part on long-lasting drug-induced adaptations dendritic spine signaling and morphology the nucleus accumbens (NAc). While influence of activity-dependent actin remodeling these phenomena has been studied extensively, role microtubules associated proteins remains poorly understood. We report that pharmacological inhibition microtubule polymerization NAc inhibited locomotor sensitization cocaine contextual reward learning. then...
Bone marrow-derived mesenchymal stromal cells (MSCs) hold promise for autologous treatment of neuropathologies. Intranasal delivery is relatively noninvasive and has recently been reported to result in transport MSCs the brain. However, ability migrate from nasal passages sites neuropathology ultimately survive not fully examined. In this paper, we harvested transgenic mice expressing enhanced green fluorescent protein (cells hereafter referred as MSC-EGFP) delivered them intranasally...