A5081960485- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Nutrition, Genetics, and Disease
- Phytochemicals and Antioxidant Activities
- Developmental Biology and Gene Regulation
- Tea Polyphenols and Effects
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Down syndrome and intellectual disability research
- Immune Response and Inflammation
- Pharmaceutical Economics and Policy
- Alzheimer's disease research and treatments
- Biochemical Analysis and Sensing Techniques
- Digestive system and related health
- Axon Guidance and Neuronal Signaling
- Infant Nutrition and Health
- Phytoestrogen effects and research
- Corneal Surgery and Treatments
- Full-Duplex Wireless Communications
- Retinoids in leukemia and cellular processes
- Neonatal and fetal brain pathology
- Autophagy in Disease and Therapy
- Plant Virus Research Studies
- 14-3-3 protein interactions
- Health Systems, Economic Evaluations, Quality of Life
MRC Laboratory of Molecular Biology
2021-2023
Tufts University
1909-2019
Fairview Health Services
2017
Gilead Sciences (United States)
2013
Nathan Kline Institute for Psychiatric Research
2006-2011
NYU Langone Health
2011
Dominican College of Blauvelt
2011
McLean Hospital
2008-2011
Harvard University
2008-2011
Columbia University
2011
Flavonoids have been investigated for possible inverse associations with various chronic degenerative diseases, but there are no epidemiologic data concerning a association between several of the main flavonoid categories and breast cancer risk. We applied recently published on content foods beverages dietary information collected in context large case-control study 820 women 1548 control women, conducted Greece. found strong, statistically significant flavone intake cancer. The odds ratio...
Adult tissue stem cells can serve two broad functions: to participate actively in the maintenance and regeneration of a or wait reserve only when activated from dormant state. The adult olfactory epithelium, site for ongoing, life-long, robust neurogenesis, contains both these functional cell types. Globose basal (GBCs) act as active population give rise all differentiated found normal tissue. Horizontal (HBCs) remain unless by injury. Here we show that HBC activation following injury...
The remarkable capacity of the adult olfactory epithelium (OE) to regenerate fully both neurosensory and nonneuronal cell types after severe epithelial injury depends on life-long persistence two stem populations: horizontal basal cells (HBCs), which are quiescent held in reserve, mitotically active globose cells. It has recently been demonstrated that down-regulation ΔN form transcription factor p63 is necessary sufficient release HBCs from dormancy. However, mechanisms by down-regulated...
Background: Ethanol consumption during pregnancy can lead to fetal alcohol spectrum disorder (FASD), which consists of the complete developmental deficits including neurological dysfunction. FASD is associated with a variety neurobehavioral disturbances dependent on age and duration exposure. exposure in neonatal rodents also induce widespread apoptotic neurodegeneration long-lasting behavioral abnormalities similar FASD. The stage rodent brains that are at peak synaptogenesis equivalent...
The olfactory epithelium (OE) regenerates after injury via two types of tissue stem cells: active globose cells (GBCs) and dormant horizontal basal (HBCs). HBCs are roused to activated status by OE when P63 levels fall. However, an in-depth understanding activation requires a system for culturing them that maintains both their self-renewal multipotency while preventing spontaneous differentiation. Here, we demonstrate mouse, rat, human can be cultured passaged as P63+ multipotent cells. in...
Neurons in the murine olfactory epithelium (OE) differ by receptor they express as well other molecular phenotypes that are regionally restricted. These patterns can be precisely regenerated following epithelial injury, suggesting spatial cues within tissue direct neuronal diversification. Nonetheless, permanency and mechanism of this patterning remain subject to debate. Via transplantation stem progenitor cells from dorsal OE into ventral OE, we demonstrate that, mice both sexes,...
Bone marrow-derived mesenchymal stromal cells (MSCs) hold promise for autologous treatment of neuropathologies. Intranasal delivery is relatively noninvasive and has recently been reported to result in transport MSCs the brain. However, ability migrate from nasal passages sites neuropathology ultimately survive not fully examined. In this paper, we harvested transgenic mice expressing enhanced green fluorescent protein (cells hereafter referred as MSC-EGFP) delivered them intranasally...
ABSTRACT Toll-like receptors (TLRs) in mammalian systems are well known for their role innate immunity. In addition, TLRs also fulfil crucial functions outside immunity, including the dorsoventral patterning function of original Toll receptor Drosophila and neurogenesis mice. Recent discoveries flies suggested key roles epithelial cells junctional cytoskeletal activity. Here, we address downstream signal transduction component IRAK4 human cells. Using differentiated Caco-2 as a model...
Biosimilars have the potential to greatly reduce medication costs in United States. As of July 1, 2017, 5 biosimilars been approved by FDA, but only 2 are available for purchase. This commentary outlines efforts an integrated health system ensure biosimilar accessibility and discusses current challenges future implications. We highlight implementation a plan policy how system's formulary committee can encourage use while considering provider perceptions operational challenges. In addition,...
Progressive multifocal leukoencephalopathy (PML) is an often-fatal demyelinating disease of the central nervous system. PML results when oligodendrocytes within immunocompromised individuals are infected with human JC virus (JCV). We have identified oligodendrocyte precursor cell line, termed G144, that supports robust levels JCV DNA replication, a part life cycle. In addition, we determined readily infects G144 cells. Furthermore, replication in cells stimulated by myristoylated (i.e.,...
The object of this research was to learn whether enterokinase found in infancy and, if so, at what age it appeared ; furthermore, effect, any the time autopsy after death, infant and disease from which died had upon amount found.It necessary rely extracts pancreas duodenum obtained room, a method been by Cohnheim others be satisfactory.As means determining digestion, Loehlein with casein solution Weber employed.Three series experiments were carried out cooked extract, intestinal pancreatic...
The object of this research was to learn whether enterokinase found in infancy and, if so, at what age it appeared ; furthermore, effect, any the time autopsy after death, infant and disease from which died had upon amount found.It necessary rely extracts pancreas duodenum obtained room, a method been by Cohnheim others be satisfactory.As means determining digestion, Loehlein with casein solution Weber employed.Three series experiments were carried out cooked extract, intestinal pancreatic...