A5073474650- Olfactory and Sensory Function Studies
- Congenital heart defects research
- Vascular Malformations Diagnosis and Treatment
- Biochemical Analysis and Sensing Techniques
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Function and Risk Factors
- Neurogenesis and neuroplasticity mechanisms
- Cardiomyopathy and Myosin Studies
- Developmental Biology and Gene Regulation
- Cardiac electrophysiology and arrhythmias
- Single-cell and spatial transcriptomics
- Growth Hormone and Insulin-like Growth Factors
- Neurobiology and Insect Physiology Research
- Trigeminal Neuralgia and Treatments
- Geographies of human-animal interactions
- Diverse academic and cultural studies
- Digital Games and Media
- Japanese History and Culture
- Advanced Chemical Sensor Technologies
- Moyamoya disease diagnosis and treatment
- Underwater Vehicles and Communication Systems
- Pituitary Gland Disorders and Treatments
- Cell Image Analysis Techniques
- Ear and Head Tumors
- Traumatic Brain Injury and Neurovascular Disturbances
Tufts University
2018-2024
Institut thématique Génétique, génomique et bioinformatique
2023
University of California, San Francisco
2010-2018
Neurological Surgery
1988-2014
University of California, Berkeley
2012
University of Wisconsin–Madison
1988
OBJECT.: Stereotactic radiosurgery (SRS) is an established treatment modality for brain arteriovenous malformations (AVMs) in children, but the optimal parameters and associated treatment-related complications are not fully understood. The authors present their single-institution experience of using SRS, at a relatively low marginal dose, to treat AVMs children nearly 20 years; they report angiographic outcomes, posttreatment hemorrhage rates, adverse events, functional outcomes.The...
In an effort to determine which blood elements play a critical role in the development of cerebral vasospasm, adult cats were subjected prepontine injection either autogenous whole or erythrocyte-free containing latex beads as substitute morphologic marker. Seven 10 days later anesthetized and perfused with fixative, basilar arteries prepared for light electron microscopy. Successful clot deposition was confirmed by presence numerous erythrocytes within adventitia vessels. agreement previous...
Craniopharyngiomas are rare epithelial tumors that presumed to arise from the remnants of Rathke's pouch.This study was designed evaluate outcome characteristics craniopharyngiomas treated in a single institution and determine whether adamantinomatous craniopharyngioma should be considered more aggressive than World Health Organization (WHO) grade I neoplasm.We identified all patients with given their diagnoses at University California, San Francisco 20-year period performed retrospective...
Efficient blood flow depends on two developmental processes that occur within the atrioventricular junction (AVJ) of heart: conduction delay, which entrains sequential chamber contraction; and valve formation, prevents retrograde fluid movement. Defects in either result severe congenital heart disease; however, little is known about interplay between these crucial processes. Here, we show AVJ delay locally assigned by morphogenetic events initiate formation. Our data demonstrate physical...
Neurons in the murine olfactory epithelium (OE) differ by receptor they express as well other molecular phenotypes that are regionally restricted. These patterns can be precisely regenerated following epithelial injury, suggesting spatial cues within tissue direct neuronal diversification. Nonetheless, permanency and mechanism of this patterning remain subject to debate. Via transplantation stem progenitor cells from dorsal OE into ventral OE, we demonstrate that, mice both sexes,...
Impulses generated by a multicellular, bioelectric signaling center termed the sinoatrial node (SAN) stimulate rhythmic contraction of heart. The SAN consists network electrochemically oscillating pacemaker cells encased in heterogeneous connective tissue microenvironment. Although cellular composition has been point interest for more than century, biological processes that drive tissue-level assembly within are unknown. Here, we demonstrate SAN's structural features result from...
Horizontal basal cells (HBCs) mediate olfactory epithelium (OE) regeneration following severe tissue injury. The dynamism of the post-injury environment is well illustrated by
While horizontal basal cells (HBCs) make minor contributions to olfactory epithelium (OE) regeneration during homeostatic conditions, they possess a potent, latent capacity activate and subsequently regenerate the OE following severe injury. Activation requires, is mediated by, downregulation of transcription factor (TF) TP63. In this paper, we describe cellular processes that drive nascent stages HBC activation. The compound phorbol 12-myristate 13-acetate (PMA) induces rapid loss in TP63...
Anomalous action potential conduction through the atrial chambers of heart can lead to severe cardiac arrhythmia. To date, however, little is known regarding mechanisms that pattern proper during development. Here we demonstrate muscle functionally diversifies into at least two heterogeneous subtypes, thin-walled myocardium and rapidly conducting bundles, a developmental window just following looping. During this process, bundles become enriched for fast markers Cx40 Nav1.5, similar...
Horizontal basal cells (HBCs) residing within severely damaged olfactory epithelium (OE) mediate OE regeneration by differentiating into odorant-detecting sensory neurons (OSNs) and other tissue supporting non-neuronal cell types. Depending on both type integrity, the Notch signaling pathway can either positively or negatively regulate resident stem activity. Although Notch1 specifies HBC dormancy in uninjured OE, little is known about how HBCs are influenced following injury. Here, we show...
Horizontal basal cells (HBCs) activate only in response to severe olfactory epithelium (OE) injury. This activation is mediated by the loss of transcription factor TP63. Using compound phorbol 12-myristate 13-acetate (PMA), we find that can model process acute HBC activation. First, PMA treatment induces a rapid TP63 protein and expression HOPX nuclear translocation RELA, previously identified mediate bulk RNA sequencing, PMA-treated HBCs pass through various stages identifiable...
Background Gamma Knife radiosurgery (GKRS) is an option in the treatment of pediatric arteriovenous malformations (AVMs), especially for AVMs eloquent locations or patients with good functional status. Prior studies have indicated that lower target volumes and higher prescription doses are associated improved obliteration rates. Certain angiographic features including maximal diameter, diffuse border, venous drainage patterns also been shown to n influence on rate after GKRS. 1 2 3 Methods...
While drafting and drawing have a few things in common: both begin with mark, are an assembly of points lines, and, act representing subject. Despite their similarities its’ fair to say they stand miles apart the creating building, broadly, practice versus […]
Somewhere near the surface of glass and silver nitrate, a mirror’s image optically responds to human observers’ movements, reflecting environment based on viewers position. As viewer approaches mirror, its’ appearance opens up wider deeper view room. It magnifies recognized by perceiver visually reflects three-dimensional scene atop its flat surface. Nearly 40 years after Dan Grahams’ written reflections mental visual mirror image,1 design for All Square, restaurant non-profit in...