A5053284948- Cancer, Stress, Anesthesia, and Immune Response
- Physiological and biochemical adaptations
- Inflammatory mediators and NSAID effects
- Muscle Physiology and Disorders
- Cancer-related molecular mechanisms research
- Aquaculture disease management and microbiota
- Marine animal studies overview
- Circular RNAs in diseases
- Cancer-related gene regulation
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Tissue Engineering and Regenerative Medicine
- Antimicrobial Peptides and Activities
- MicroRNA in disease regulation
- Receptor Mechanisms and Signaling
- Pluripotent Stem Cells Research
- Dental Research and COVID-19
- Epigenetics and DNA Methylation
- Crustacean biology and ecology
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
- Probiotics and Fermented Foods
- Nicotinic Acetylcholine Receptors Study
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
University of California, Berkeley
2020-2024
Stony Brook University
2023
Berkeley College
2020-2023
Acupuncture & Integrative Medicine College
2021-2022
San Francisco State University
2019-2022
Integra (United States)
2021
Chinese University of Hong Kong
2005-2018
Prince of Wales Hospital
2009-2014
University of Hong Kong
2005-2011
<h3>Objective:</h3> MicroRNAs (miRNAs) have been shown to offer great potential in the diagnosis of cancer. We investigated whether plasma miRNAs could discriminate between patients with and without colorectal cancer (CRC). <h3>Methods:</h3> This study was divided into three phases: (1) marker discovery using real-time PCR-based miRNA profiling on plasma, corresponding cancerous adjacent non-cancerous colonic tissues five CRC, along from healthy individuals as controls; (2) selection...
Cigarette smoking is a risk factor for colorectal cancer. It suggested that 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), tobacco-specific nitrosamine, mediates the carcinogenic action of cigarette by promoting cancer growth. In present study, proliferative response cultured colon cell line HT-29 to NNK was determined. found dose-dependently stimulated proliferation. this regard, stimulatory abolished atenolol and ICI 118,551, beta1- beta2-selective antagonist, respectively....
Cigarette smoking is a putative environmental risk factor for colon cancer. Nicotine, an active alkaloid in tobacco, has been implicated carcinogenesis. In the present study, we demonstrated that oral nicotine administration (50 or 200 microg/ml) 25 days stimulated growth of human cancer xenograft nude mice. It also increased vascularization tumors and elevated cotinine adrenaline plasma levels. beta-Adrenoceptors, cyclooxygenase-2 (COX-2), prostaglandin E(2) (PGE(2)), vascular endothelial...
Abstract Blockade of angiogenesis is a promising strategy to suppress tumor growth, invasion, and metastasis. Vascular endothelial growth factor (VEGF), which binds tyrosine kinase receptors [VEGF (VEGFR) 1 2], the mediator mitogen for cells. Cyclooxygenase-2 (COX-2) plays an important role in promoting action nicotine on gastric cancer growth. However, relationship between COX-2 VEGF/VEGFR system tumorigenesis remain undefined. In this study, effects angiogenesis, invasiveness, metastasis...
We previously reported that nicotine promoted gastric cancer cell growth via upregulation of cyclooxygenase 2 (COX-2). In the present study, we further investigated whether beta-adrenoceptors, protein kinase C (PKC), and extracellular signal-regulated kinase-1/2 (ERK1/2) were involved in modulation COX-2 expression proliferation by AGS, a human adenocarcinoma line. Results showed dose dependently increased phosphorylation EKR1/2 AP-1 subunits c-fos c-jun. this connection, ERK1/2 inhibitor...
Cathelicidin, an antimicrobial peptide of the innate immune system, modulates microbial growth, wound healing, and inflammation. However, its association with inflammatory bowel diseases (IBDs) is unknown. Our objective was to determine whether cathelicidin would exert a modulatory effect on progression IBD and, if so, investigate mechanism action through which this occurred. We evaluated potential for synthetic cathelicidin, mouse cathelin-related (mCRAMP), prevent initiation promote...
Abstract Mucus forms the physical barrier along gastrointestinal tract. It plays an important role to prevent mucosal damage and inflammation. Our animal study showed that antibacterial peptide ‘cathelicidin’ increased mucus thickness prevented inflammation in colon. In current study, we examined direct effect mechanisms by which synthesis a human colonic cell line (HT‐29). Human cathelicidin (LL‐37) dose‐dependently (10–40 µg/ml) significantly stimulated increasing D ‐[6‐ 3 H] glucosamine...
Cathelicidin, a cationic host defense peptide, has been shown to promote cutaneous wound repair and reaches high levels in the gastric mucosa during infection inflammation. Therefore, we investigated whether this peptide contributes ulcer healing rats. Ulcer induction increased expression of rat cathelicidin rCRAMP mucosa. Further increase by local injection rCRAMP-encoding plasmid promoted enhancing cell proliferation angiogenesis. directly stimulated cultured epithelial cells (RGM-1),...
The TP53‑induced glycolysis and apoptosis regulator (TIGAR) is the protein product of p53 target gene, C12orf5. TIGAR blocks promotes cellular metabolism via pentose phosphate pathway; it production nicotinamide adenine dinucleotide (NADPH), which leads to enhanced scavenging intracellular reactive oxygen species, inhibition oxidative stress‑induced in normal cells. Our previous study identified a novel nucleoside analog that inhibited growth induced nasopharyngeal carcinoma (NPC) cell lines...
Regular surveillance testing of asymptomatic individuals for SARS-CoV-2 has been center to outbreak prevention on college and university campuses. Here we describe the voluntary saliva program instituted at University California, Berkeley during an early period pandemic in 2020. The was administered as a research study ahead clinical implementation, enabling us launch while continuing optimize assay. Results both protocol itself participants’ experience show how succeeded providing routine,...
Synopsis Microclimatic variation has emerged as an important driver of many ecological and evolutionary processes. Nonetheless, fine-scale temperature data are still rare in most habitats, limiting our ability to understand the consequences microclimatic under current future conditions. We measured thermal a common, species-rich, but rarely studied habitat with respect temperature: airspaces rocks on intertidal zone boulder shores. The effects were investigated using physiological,...
In the present study, patch clamp experiments demonstrated expression of multiple ionic currents, including a Ba2+-sensitive inward rectifier K+ current (IKir), 4-aminopyridine- (4-AP) sensitive delayed (IKDR), and nifedipine-sensitive, tetrodotoxin-resistant Na+ (INa.TTXR) in non-transformed rat gastric epithelial cell line RGM-1. RT-PCR revealed molecular identities mRNAs for functional Kir1.2 IKir, Kv1.1, Kv1.6, Kv2.1 IKDR, Nav1.5 INa.TTXR. Pharmacologic blockade Kv Nav, but not Kir,...
Marine mammals exhibit some of the most dramatic physiological adaptations in their clade and offer unparalleled insights into mechanisms driving convergent evolution on relatively short time scales. Some these adaptations, such as extreme tolerance to hypoxia prolonged food deprivation, are uncommon among terrestrial challenge established metabolic principles supply demand balance. Non-targeted omics studies starting uncover genetic foundations but tools for testing functional significance...